DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and Cct3

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_033966.1	Gene:	Cct3 / 12462	MGIID:	104708	Length:	545	Species:	Mus musculus

Alignment Length:	538	Identity:	170/538 - (31%)
Similarity:	288/538 - (53%)	Gaps:	35/538 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSLNPVRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDG 67
            |...||.||....:.|.....:..:...|..|.|::::.||||.|.|:|:..   .|.:.:||||
Mouse     2 MGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDP---MGGIVMTNDG 63

  Fly    68 ATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQ 132
            ..|||.:.|.:||||.::::||.||||||||||||.:||.|:|..||..:||::||.:::|.:|.
Mouse    64 NAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRM 128

  Fly   133 ATQVALEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLK----GS 193
            |..   :.::...:.::..|...|..:|:|..:::::|::.:......|:|:|||..::    |.
Mouse   129 ALD---DMISTLKKISTPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGR 190

  Fly   194 GEL---KSIQIIKKSGGTLGDSFLDEGFLLDKKPGVHQPQR--IENARILIANTPMDTDKIKVFG 253
            .|:   |..::.|..||.:.||.:..|.:::|.. .|...|  |:|.||::.::.::..|    |
Mouse   191 KEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDV-THPRMRRYIKNPRIVLLDSSLEYKK----G 250

  Fly   254 SS---IKVDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHA 315
            .|   |::........:...|:|.:.:..:.|::.|.:|.|..:.|.:..:.....|.|.:|...
Mouse   251 ESQTDIEITREEDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRV 315

  Fly   316 DFDGIERLAYCTGGEIVSTFENPSLVKLGECDV------IEQVMIGEDTLLRFSGVKLGEACTIV 374
            ......|:|...|..|||..|     :|.|.||      :|...||::.....:..|..:||||:
Mouse   316 RKTDNNRIARACGARIVSRPE-----ELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTIL 375

  Fly   375 IRGATQQILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAF 439
            :|||:::||.|.:|:|.||:.|....:.:.:::.|||.||..:|.|:.:|:....|.|.....|.
Mouse   376 LRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAV 440

  Fly   440 ARALLSLPTAIADNAGYDSAQLVSELRAGHAQGK-QTLGLDMELGKVADVRELGITESFAVKRQV 503
            |:||..:|..:..|.|..:.:|::.|||.|.|.. :|.|::.|.|.:.|::||||.|..|||.|.
Mouse   441 AQALEVIPRTLIQNCGASTIRLLTSLRAKHTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQT 505

  Fly   504 LMSASEAAEMILRVDNII 521
            ..:|.|.|.::||:|:|:
Mouse   506 YKTAVETAVLLLRIDDIV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	170/538 (32%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	167/531 (31%)
Cct3	NP_033966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		6/21 (29%)
		chap_CCT_gamma	6..529	CDD:274085	169/534 (32%)
		TCP1_gamma	6..525	CDD:239453	169/534 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810