Protein Alignment APC4 and APC4

DIOPT Version :10

• Sequence 1: NP_572522.2
• Gene: APC4 / 31835
• FlyBaseID: FBgn0052707
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: NP_010403.3
• Gene: APC4 / 851696
• SGDID: S000002525
• Length: 652
• Species: Saccharomyces cerevisiae
• Alignment Length: 719
• Identity: 129/719 - (17%)
• Similarity: 234/719 - (32%)
• Gaps: 225/719 - (31%)

  Fly    22 MEWNNKMDLIAYGTEKGEVVIQRLNWQKIVTFPTPGEDVRVRSLSWQMDET---LLAVGYSNGKV 83
            :::|....:.|....||..:.:..:..::...|....:: |.:..|  |.|   .|::.:.:|.:
Yeast    10 IDYNPLFPIFATRIAKGLAIYRVSDHARLAVIPIRNINL-VANYDW--DTTTGKFLSIFFKDGTI 71

  Fly    84 ALLDA-ESGTIISGL-IYEDDIKKVYFSK-AINSQENLGTYTCNVKDKHRRFLPKL--------- 136
            .:.|. :.|.::|.| |....|.|..:.: .:..:.|...:.||:.|.    ||||
Yeast    72 RIHDIFKDGRLVSFLRIPSTKISKGIWDRIPLRYEPNNRDFACNIIDD----LPKLIRFVKDSKR 132

  Fly   137 ---QPMTNIDPCLKTLDQKSFPKGSPCFLVVIMRSGKVHLLLLGALQAGSIDLTQHILHPHEFDV 198
               .|.|..:...:..|:..........:.|:...|.                          |.
Yeast   133 INIVPYTQPNSLWRGPDEDDLDSNEKLDVHVVFNEGN--------------------------DK 171

  Fly   199 YDVRMNGDC------------NAIYALLRDGQELILLHFQNQVLQDC-MAPMLE------LATHC 244
            ..|..|||.            |::.::::.........:::..:|.. :.|:|:      |..:.
Yeast   172 ITVFFNGDYAVFLSVDNIENENSLKSIIKVQDGFYQCFYEDGTVQTLNLGPLLQSKSSVNLLNYI 236

  Fly   245 AHILETKNYINDTQQCLTEAWETVQLEMDNKLTRYANSQPYGVISAHFLELHVFGFATFEVEEFL 309
            ..|.|...|:....:.:.....|..|:...:|...|..  ||.:.:....|.:.|..:.::|::|
Yeast   237 MVIKELIGYMLTHLEFINRELATPYLDFVKRLCDEAYG--YGKLKSELEALFLLGEISCDLEDWL 299

  Fly   310 FETLSEKGFKK--------------------------------------IANSVDLSLSNLQSLV 336
            ..::.||.||:                                      .|.|:...||....|.
Yeast   300 CNSVGEKNFKRWKYLGCEAYQKTVQILTLIFVPACERIIIYVEKLRAILQAFSIQNKLSYTSDLT 364

  Fly   337 FKQ--LNGAAINMFYFLNTIAGFGRMSHFFESLISPDVANEAMRACGGFVLKVHELQRTIDTLAY 399
            ..:  |..:...:...||:|.|.||....||....            .|..::||      .|..
Yeast   365 AVEVLLKSSQKLLTMTLNSIIGLGRDETLFEKFFI------------WFNDRLHE------ALDE 411

  Fly   400 DMKL---FHAWMIFTILRLSHQEIPDDLVL----TEEENI----AMADFICAMEPELDDRSDDED 453
            |.||   |...:.|....||:    .|.:|    ||..:|    ...|.|.:|       ||.|.
Yeast   412 DYKLKFQFEDDLYFGYDLLSY----FDRILSKKGTEPSSIIDVKLYRDLINSM-------SDMEK 465

  Fly   454 ELDSQSQTPPPARSKFNLERVGQY----LDNAYLTQLYPRDPVQLWEEM-------------VTD 501
            ::         |:|..| ..:.|:    |......|.||...:.|.:.:             ||.
Yeast   466 DI---------AQSNVN-SHIQQHILVDLKTDVFAQKYPSSQINLLDAIKLPKHNYIVYLIQVTK 520

  Fly   502 NECL-------SNCKLFVP--HDVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSST-VICND 556
            :...       :..||::.  .|.||.::.:...:  .|.|:|.        |:::||| .:.|.
Yeast   521 HNSAQEPFSEENKKKLYIGTLKDENLGIISKESSV--KIPALFK--------SYRLSSTRFVPNR 575

  Fly   557 LPPM---------------------EPGEDHRDRDLVTCTYYVNE-ASRTDMLACT----ISGQE 595
            :..:                     |..|:..|...:....|:.| ....|.:|||    :.|:.
Yeast   576 VHSLLRDIGLSDSNYHSSHVTDYRGENYENEEDDGTIAIPAYIRENRENDDFIACTAKVSVDGRS 640

  Fly   596 AMIL 599
            |.::
Yeast   641 ASLV 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	22..111	CDD:403945	18/94 (19%)
		ANAPC4	222..418	CDD:463744	46/245 (19%)
APC4	NP_010403.3	ANAPC4	223..411	CDD:463744	45/236 (19%)