DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APC4 and APC4

DIOPT Version :9

Sequence 1:	NP_572522.2	Gene:	APC4 / 31835	FlyBaseID:	FBgn0052707	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_193884.6	Gene:	APC4 / 828238	AraportID:	AT4G21530	Length:	777	Species:	Arabidopsis thaliana

Alignment Length:	843	Identity:	187/843 - (22%)
Similarity:	313/843 - (37%)	Gaps:	213/843 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EWNNKMDLIAYGTEKGEVVIQRLNWQKIVTFPTPGEDVRVRSLSWQMDETLLAVGYSNGKVALLD 87
            |||.:.||:|..||..::::.|.|||::.|. :||:.  |.||.|:.|...:|||..:|.::|.|
plant    31 EWNPEKDLLAMVTEDSKILLHRFNWQRLWTI-SPGKP--VTSLCWRPDGKAIAVGLEDGTISLHD 92

  Fly    88 AESGTIISGLIYEDDIKKVYFSKAINSQENL---GTYTCNVKDKHRRFLPKL-QP---------- 138
            .|:|.::..| ...|:..|..:...:.|.|.   |.::. .:|:..||.|.. :|
plant    93 VENGKLLRNL-KPHDVAVVCLNWEEDGQSNTDESGNFSV-YEDRTSRFFPPAPRPPKMPGLVAGD 155

  Fly   139 ---MTNIDPCLKTLDQKSFPKGSPCFLVVIMRSGKVHLLLLGALQAGSIDLTQHILH-PH----- 194
               |.:.:..|..|...||.|.:  .|....|.|.:...:.|..|.|.|::.:..|. ||
plant   156 SSFMDDGEDSLAELSNTSFRKFN--ILCTGDRDGNICFSIFGIFQIGKINIHELSLPVPHLDEHA 218

  Fly   195 -----EFDVYDVRMNGD-CNAIYAL---LRD-----------GQELILLHFQNQVLQDCMA---- 235
                 ...:|.|.::.| |..:...   |:|           .|:|..||        |:|
plant   219 SCKLFNASIYKVALSKDLCRLVVMCTGELKDCDIKPREEKINVQDLPGLH--------CLAMDTS 275

  Fly   236 -------PMLELATHCAHILETKNYINDTQQCLTEAWETVQ------------LEMDNKLTRYAN 281
                   .:.::|...::|.:....|..:...:.:.|....            |.:||.|    .
plant   276 IFWKRKYELHQVAQQASNIEDLTEVIRASLSVMNKQWADAMKTFHEKFHSLSTLIIDNGL----E 336

  Fly   282 SQPYGVISAHFLELHVFGFATFE--VEEFLFETLSEKGFKKIANSVDLSLSNLQSLVFKQLNGAA 344
            |.|    ...||.|  .|.|...  :.:||..:|.|.|.|::..||..:...||.:|...|..||
plant   337 SSP----QEEFLSL--LGGARISPALNQFLVNSLGEVGVKRVLKSVCGTGKELQQVVLDHLQPAA 395

  Fly   345 INMFYFLNTIAGFGRMSHFFESL-ISPDVANEAMRACGGFVLKVHELQRTIDTLAYDMKLFHAWM 408
            ..:.:.:..:.|..|....::.: :...:.|||....|..:::|......:.::......|..|:
plant   396 EIIGFRIGELRGLSRWRARYQGIGLDEMLLNEATENTGLLLVQVQRFMMVLSSVVQQFSNFFNWL 460

  Fly   409 IFTILRLSHQEIPDDLVLT--EEENIAMADFICAMEP-----ELDDRSDDEDELDSQSQTPPPAR 466
            :.:|..|..:  |:|.:|:  .|..:....|:...:|     ||.:..|| .|:|
plant   461 VRSIKYLMQE--PNDQLLSYNSELLVVFLKFLYDQDPVKDLLELSEAGDD-IEID---------- 512

  Fly   467 SKFNLERVGQYLDNAYLTQLYPRDPVQLWEEMVTDNECLSNCKLFVPHDVNLSLVQQRDKMFNAI 531
                |:.:|:..:   |.|.                ...|.|..     :..:|.::...|.::.
plant   513 ----LKTIGRVKE---LLQF----------------GGFSECDF-----LQRTLAKEFQHMESSF 549

  Fly   532 DAVFHKPTESISGSFKVSSTVICNDLPPMEPGEDHRDRDLVT----CTYYVNEAS--------RT 584
            ...|..|..:||.  |:|    |..|.|:.|.:....:...|    .::|.||.|        .|
plant   550 KMAFQMPFTTISR--KIS----CMKLLPLCPLQLSTTQTPTTIPMSLSFYKNELSDDTPCQSGYT 608

  Fly   585 DMLACTISGQEAMILEFSRAGDECVRCTRITLEPGLFTTSVSEDFCYLRF-------------VD 636
            |.::..:..:         ...|...|  |.:..|....|.:|...|...             ||
plant   609 DYISFQVPDE---------TFPEISNC--IGIAKGYKQNSNNEKNGYTSLEAVLLSVPNGYTCVD 662

  Fly   637 LQFYNESSLSILAQSINA---GPG-------MRPHSFFIQFSLTAALN-YSTQHRMGPLVKL--S 688
            |..|.:..|.:|....|.   |.|       ......||..|.:::|| :..:...|.:|.|  .
plant   663 LSLYKDKELVLLLNKTNTDSEGSGEACMMVVQTGDLAFISISGSSSLNQWELEDLKGSIVNLEME 727

  Fly   689 EATVSQSIHDIADGAAFKGLDGFSDMLAVSGSRKVATVLSDRKRKMTIFEMEIEEEEDDTEMS 751
            ...|.:..|.:.            ..||||.||.||.|.::|:|.:    :.|.||::|.|:|
plant   728 NEKVRKVPHSVI------------APLAVSASRGVACVFAERRRAL----VYILEEDEDEEIS 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	6..52	CDD:289649	12/28 (43%)
		WD40 repeat	20..54	CDD:293791	13/30 (43%)
		WD40 repeat	62..98	CDD:293791	13/35 (37%)
		ANAPC4	222..418	CDD:289651	44/221 (20%)
APC4	NP_193884.6	ANAPC4_WD40	14..60	CDD:289649	12/28 (43%)
		WD40	<29..192	CDD:225201	51/177 (29%)
		WD40	<32..>120	CDD:295369	30/87 (34%)
		WD40 repeat	68..104	CDD:293791	13/35 (37%)
		ANAPC4	268..470	CDD:289651	49/223 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4640
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I2059
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351579at2759
OrthoFinder	1	1.000	-	-		FOG0003724
OrthoInspector	1	1.000	-	-		oto4019
orthoMCL	1	0.900	-	-		OOG6_103906
Panther	1	1.100	-	-	LDO	PTHR13260
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.870