DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APC4 and anapc4

DIOPT Version :9

Sequence 1:	NP_572522.2	Gene:	APC4 / 31835	FlyBaseID:	FBgn0052707	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	XP_005160577.1	Gene:	anapc4 / 494046	ZFINID:	ZDB-GENE-041212-10	Length:	806	Species:	Danio rerio

Alignment Length:	814	Identity:	202/814 - (24%)
Similarity:	348/814 - (42%)	Gaps:	124/814 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SMKLLGARNMSCIVERMEWNNKMDLIAYGTEKGEVVIQRL-NWQKIVTFPTPGEDV--RVRSLSW 67
            :.:.:|.:.:...:..|.|..|.||||.....||:::.|| |:.::.:.| |.|:.  .:.||:|
Zfish     3 AFRQVGEKQLPNPILYMAWCPKRDLIALANTTGELLLHRLANFHRVWSLP-PNENTGKEITSLAW 66

  Fly    68 QMDETLLAVGYSNGK-VALLDAESGTIISGLIYEDDIKKVYFSKAINSQENLGTYTCNVKDKHRR 131
            :.|..:||....:.| |.|.|||...|:.....|.....:::.:..:....|.::: ..:|:..|
Zfish    67 RPDGKVLAFSVGDTKQVVLCDAEKAEILHLFPVEYPASCMHWMEVQDDSSTLTSFS-ESEDESSR 130

  Fly   132 FLPKLQPMTNIDPCLKTLDQKSFPKGSPCF-------LVVIMRSGKVHLLLLGALQAGSIDLTQH 189
            |||||       |.|    .||:...|..|       :..::...::::|::|. .:|.::|
Zfish   131 FLPKL-------PTL----PKSYSTTSKIFSEEKSEEVTNLLGEVRLNILVVGG-PSGFVEL--- 180

  Fly   190 ILHPHEFDVYDVR-------------MNGDCNAIYALLR-----DGQELILLHFQNQVLQDCMAP 236
                :.:.:|.:.             ::.|..::..:..     |..|:..:.....:|..|:..
Zfish   181 ----YAYGLYKIATLSGILGTCRSLGLSSDLKSLSVITEIRSTDDNPEIRYIQLDTGLLSSCLPE 241

  Fly   237 MLELATHCAHILETKNYINDTQQCLTEAWETVQLEMDNKLTRYANSQPYGV-ISAHFLELHVFGF 300
            :.::|....||.....|:..:..|:.||||.:.::||.:||::...:.... :...||||.::|.
Zfish   242 LTKMARKFTHISTLLQYLRVSLTCMCEAWEEILMQMDLRLTKFVQEKNTSTQVQDEFLELLLWGH 306

  Fly   301 ATFEVEEFLFETLSEKGFKKIANSVDLSLSNLQSLVFKQLNGAAINMFYFLNTIAGFGRMSHFFE 365
            |:.|::..|...|:.||.|.:..|:|.|.|::|.||...|...:..:.|.|:.:.|.......|:
Zfish   307 ASPELQALLMNQLTVKGLKMLGQSIDSSYSSIQKLVISHLQSGSEALLYHLSEVKGMALWKQKFQ 371

  Fly   366 SL-ISPDVANEAMRACGGFVLKVHELQRTIDTLAYDMKLFHAWMIFTILRLSHQEIPDDL-VLTE 428
            .| :.|....:|:.|.|.|.||..||.:.||....:.|.|..|:...:||:|...:|.:| .:|:
Zfish   372 PLGLDPSDIEDAIVAVGSFTLKASELLQVIDKSMKNFKAFFRWLYVAMLRMSEDHVPPELNKMTQ 436

  Fly   429 EENIAMADFIC---AMEPELDDRSDDEDELDSQSQTPPPARSKFNLERVGQYL---DNAYLTQLY 487
            ::...:|||:.   :...||.||..                ..||:|||||||   |...::.
Zfish   437 KDLAFVADFLSEHFSANEELFDRKG----------------KYFNVERVGQYLKDEDEDLVSP-- 483

  Fly   488 PRDPVQLWEEMVTDNECLSNCKLFVPHDVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSSTV 552
            |......|...|..:..|.:..|..|.....||...:..|..:||....||...|..|.|   ..
Zfish   484 PNMDGNQWVTFVKQSTHLKDSPLLFPTYPQKSLHFVKRLMEASIDLCLQKPAAVIGDSVK---QA 545

  Fly   553 ICNDLPPMEPGEDHRDR---------DLVTCTYYV----NEAS---------RTDMLACTISGQE 595
            :|..|..:....::..|         |.....:||    .|.|         .||......:|..
Zfish   546 VCLRLYTVPESSENTPRLFELPSLWNDKKAAMHYVVFCMPEISPSKIYILRRPTDPNRSVPNGLV 610

  Fly   596 AMILEF---SRAGDECVRCTRITLEPGLFTTSVSEDFCYLRFVDLQFYNESSLSILAQSINAGPG 657
            |:.|..   |...||       |..|      .|.|:.| ..:|.:||::.:|:::.:.:.....
Zfish   611 ALNLNTPLNSSIDDE-------TPAP------ASVDYSY-SCLDARFYDDETLTVVLRRLEDDEN 661

  Fly   658 -MRPHSFFIQFSLTAALNYSTQHRMGPLVKLSEATVSQSIHDIADGAAFKGLDGFS-DMLAVSGS 720
             ||   ...|..|.:|:::..:......::|.:.|....:..:|.|...:.:|..| ..:||:|.
Zfish   662 KMR---VLAQLPLNSAMSWDEEFSWDLSLRLEQQTEGIPVQGVAWGNQSREMDNISAQFVAVNGI 723

  Fly   721 RKVATVLSDRKRKMTIFEMEIEEEEDDTEMSQAS 754
            ||||.|||...|.:.:|||:.|||||:.|.:..|
Zfish   724 RKVACVLSANLRHVRVFEMDAEEEEDEEERADES 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	6..52	CDD:289649	13/46 (28%)
		WD40 repeat	20..54	CDD:293791	12/34 (35%)
		WD40 repeat	62..98	CDD:293791	13/36 (36%)
		ANAPC4	222..418	CDD:289651	57/197 (29%)
anapc4	XP_005160577.1	ANAPC4_WD40	3..50	CDD:289649	13/46 (28%)
anapc4	XP_005160577.1	ANAPC4	226..425	CDD:289651	57/198 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594608
Domainoid	1	1.000	104	1.000	Domainoid score	I6697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40873
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3803
OMA	1	1.010	-	-		QHG49644
OrthoDB	1	1.010	-	-		D302186at33208
OrthoFinder	1	1.000	-	-		FOG0003724
OrthoInspector	1	1.000	-	-		oto41046
orthoMCL	1	0.900	-	-		OOG6_103906
Panther	1	1.100	-	-	LDO	PTHR13260
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10441
SonicParanoid	1	1.000	-	-		X4742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940