DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APC4 and Anapc4

DIOPT Version :9

Sequence 1:	NP_572522.2	Gene:	APC4 / 31835	FlyBaseID:	FBgn0052707	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_001100690.1	Gene:	Anapc4 / 305420	RGDID:	1306572	Length:	807	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	198/839 - (23%)
Similarity:	360/839 - (42%)	Gaps:	130/839 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SMKLLGARNMSCIVERMEWNNKMDLIAYGTEKGEVVIQRL-NWQKIVTFPTPGEDV--RVRSLSW 67
            |.:::|.:.:...:..:.|:.|.||||.....|||::.|| ::.::.:|| |.|..  .|..|:|
  Rat    10 SFRVVGEKQLPQEIIFLAWSPKRDLIALANTTGEVLLHRLASFHRVWSFP-PNESTGKEVTCLAW 73

  Fly    68 QMDETLLAVGYSN-GKVALLDAESGTIISGLIYEDDIKKVYFSKAINSQENLGTYTCNVKDKHRR 131
            :.|..|||...:: .|:.|.|.|....:.....|..:..:::.: :..:.::.|...|.:|:...
  Rat    74 RPDGKLLAFALADTKKIILCDVEKPESLHSFSVEAPVSCMHWME-VTVESSVLTSFYNAEDESNL 137

  Fly   132 FLPKLQPMTNIDPCLKTLDQKSFPKGSPCFLVVIMRSGKVHLLLLGALQAGSIDLTQHILHPHEF 196
            .||||..:    |.......|.|.:.:...::.::...::::|:||. .:|.|:|       :.:
  Rat   138 LLPKLPTL----PKNYNSTSKIFSEENSDEIIKLLGDVRLNILVLGG-SSGFIEL-------YAY 190

  Fly   197 DVYDV-RMNGDCNAIYAL--------------LRDGQELILLHFQ--NQVLQDCMAPMLELATHC 244
            .::.: |:.|......||              :..|.|..:.:||  ..:|...:|.:..:|...
  Rat   191 GMFKIARVTGIAGTCIALCLSSDLKSLSVVTEVSSGGESEVSYFQLETNLLYSFLAEVTRMARKF 255

  Fly   245 AHILETKNYINDTQQCLTEAWETVQLEMDNKLTRYANSQPYGV-ISAHFLELHVFGFATFEVEEF 308
            .||.....|||.:..|:.||||.:.::||::||::...:.... :...|:.|.::|.|:.|::..
  Rat   256 THISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKTTTTSVQDEFMHLLLWGKASAELQTL 320

  Fly   309 LFETLSEKGFKKIANSVDLSLSNLQSLVFKQLNGAAINMFYFLNTIAGFGRMSHFFESL-ISPDV 372
            |...|:.||.||:..|::.|.|::|.||...|...:.::.|.|:.:.|.......:|.| :....
  Rat   321 LMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLLYHLSELKGMASWKQKYEPLGLDASS 385

  Fly   373 ANEAMRACGGFVLKVHELQRTIDTLAYDMKLFHAWMIFTILRLSHQEI-PDDLVLTEEENIAMAD 436
            ..:|:.|.|.|:||.:||.:.||:...:.|.|..|:...:||::...: |:...:|:::...:|:
  Rat   386 IEDAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE 450

  Fly   437 FICA---MEPELDDRSDDEDELDSQSQTPPPARSKFNLERVGQYL---DNAYLTQLYPRDPVQLW 495
            |:..   ..|:|.:|..                ..||:|||||||   |:..::.  |......|
  Rat   451 FLTEHFNEAPDLYNRKG----------------KYFNVERVGQYLKDEDDDLVSP--PNTEGNQW 497

  Fly   496 EEMVTDNECLSNCKLFVPHDVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSSTVICNDLPPM 560
            .:.:.::..|....|..|:....||...:.:|.|.||....||.:.|..|.   :..||..|...
  Rat   498 YDFLQNSNHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKPADVIGRSM---NQAICIPLYKD 559

  Fly   561 EPGEDHRDRDLVTCTYYVNEASRTDMLACTI---SGQEAMILEFSRAGDECVRCTRITLEPGLFT 622
            ....|...|.|.....:.|:.|....|..||   |..:..||.......:.|....|.::.|.||
  Rat   560 ARSMDGARRLLKFPFLWNNKTSNLHYLLFTILEDSVYKMCILRRHTDSSQSVSNGLIGIKFGSFT 624

  Fly   623 TSVSEDF------CYLRFVDLQFYNESSLSILAQSINAGPGMRPHSFFIQFSLTAALN------- 674
            .:.::..      |    :|.|||::.:::::.:......|.  ....:|..|:...|
  Rat   625 YATTDKVRRSTYSC----LDAQFYDDETVTVILKDSMGREGR--DRILVQLPLSLVYNSEDSDEY 683

  Fly   675 -----YSTQ-HRMGPLV-----------KLSEATVSQSIHDIADGAAFKGLDGFSDMLAVSGSRK 722
                 .||: ...|.::           :|.|:..:|.:                   |.:|.||
  Rat   684 EFTGTCSTRLDEQGSIIPTRTMHFEKHWRLLESMKAQYV-------------------AGNGLRK 729

  Fly   723 VATVLSDRKRKMTIFEMEIEEE------EDDTEMSQASFLDISKESVLAGVPDAEKQEA 775
            |:.|||...|.:.:|||:|::|      .||.|.:....:.| ||.||:.......|:|
  Rat   730 VSCVLSSNLRHVRVFEMDIDDEWELDESSDDDEEAAGKPVKI-KEEVLSESETEAHQDA 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	6..52	CDD:289649	13/46 (28%)
		WD40 repeat	20..54	CDD:293791	11/34 (32%)
		WD40 repeat	62..98	CDD:293791	11/36 (31%)
		ANAPC4	222..418	CDD:289651	57/199 (29%)
Anapc4	NP_001100690.1	WD40 repeat	24..59	CDD:293791	11/34 (32%)
		ANAPC4_WD40	26..118	CDD:403945	27/93 (29%)
		WD40 repeat	68..102	CDD:293791	11/33 (33%)
		ANAPC4	232..431	CDD:403947	57/198 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352665
Domainoid	1	1.000	104	1.000	Domainoid score	I6581
eggNOG	1	0.900	-	-		E1_KOG4640
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40873
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3882
OMA	1	1.010	-	-		QHG49644
OrthoDB	1	1.010	-	-		D302186at33208
OrthoFinder	1	1.000	-	-		FOG0003724
OrthoInspector	1	1.000	-	-		oto96069
orthoMCL	1	0.900	-	-		OOG6_103906
Panther	1	1.100	-	-	LDO	PTHR13260
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4742
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770