DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APC4 and ANAPC4

DIOPT Version :9

Sequence 1:	NP_572522.2	Gene:	APC4 / 31835	FlyBaseID:	FBgn0052707	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_001273685.1	Gene:	ANAPC4 / 29945	HGNCID:	19990	Length:	809	Species:	Homo sapiens

Alignment Length:	828	Identity:	201/828 - (24%)
Similarity:	365/828 - (44%)	Gaps:	108/828 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SMKLLGARNMSCIVERMEWNNKMDLIAYGTEKGEVVIQRL-NWQKIVTFPTPGEDV--RVRSLSW 67
            |.:::|.:.:...:..:.|:.|.||||.....|||::.|| ::.::.:|| |.|:.  .|..|:|
Human    10 SFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFP-PNENTGKEVTCLAW 73

  Fly    68 QMDETLLAVGYSN-GKVALLDAESGTIISGLIYEDDIKKVYFSKAINSQENLGTYTCNVKDKHRR 131
            :.|..|||...:: .|:.|.|.|....:.....|..:..:::.: :..:.::.|...|.:|:...
Human    74 RPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWME-VTVESSVLTSFYNAEDESNL 137

  Fly   132 FLPKLQPMTNIDPCLKTLDQKSFPKGSPCFLVVIMRSGKVHLLLLGALQAGSIDLTQHILHPHEF 196
            .||||..:    |...:...|.|.:.:...::.::...::::|:||. .:|.|:|       :.:
Human   138 LLPKLPTL----PKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG-SSGFIEL-------YAY 190

  Fly   197 DVYDV-RMNGDCNAIYAL----------------LRDGQELILLHFQNQVLQDCMAPMLELATHC 244
            .::.: |:.|......||                .....|:.....:..:|...:..:..:|...
Human   191 GMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKF 255

  Fly   245 AHILETKNYINDTQQCLTEAWETVQLEMDNKLTRYANSQPYGV-ISAHFLELHVFGFATFEVEEF 308
            .||.....|||.:..|:.||||.:.::||::||::...:.... :...|:.|.::|.|:.|::..
Human   256 THISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTL 320

  Fly   309 LFETLSEKGFKKIANSVDLSLSNLQSLVFKQLNGAAINMFYFLNTIAGFGRMSHFFESLISPDVA 373
            |...|:.||.||:..|::.|.|::|.||...|...:.::.|.|:.:.|.......:|.| ..|.|
Human   321 LMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLLYHLSELKGMASWKQKYEPL-GLDAA 384

  Fly   374 --NEAMRACGGFVLKVHELQRTIDTLAYDMKLFHAWMIFTILRLSHQEIPDDL--VLTEEENIAM 434
              .||:.|.|.|:||.:||.:.||:...:.|.|..|:...:||::...:..:|  |:|:::...:
Human   385 GIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFV 449

  Fly   435 ADFICA---MEPELDDRSDDEDELDSQSQTPPPARSKFNLERVGQYL---DNAYLTQLYPRDPVQ 493
            |:|:..   ..|:|.:|..                ..||:|||||||   |:..::.  |.....
Human   450 AEFLTEHFNEAPDLYNRKG----------------KYFNVERVGQYLKDEDDDLVSP--PNTEGN 496

  Fly   494 LWEEMVTDNECLSNCKLFVPHDVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSSTVICNDLP 558
            .|.:.:.::..|....|..|:....||...:.:|.|.||....||.:.|.   |..:..||..|.
Human   497 QWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKPADVIG---KSMNQAICIPLY 558

  Fly   559 PMEPGEDHRDRDLVTCTYYVNEASRTDMLACTI---SGQEAMILEFSRAGDECVRCTRITLEPGL 620
            .....||...|.......:.|:.|....|..||   |..:..||.......:.|....|.::.|.
Human   559 RDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGS 623

  Fly   621 FTTSVSEDF------CYLRFVDLQFYNESSLSILAQSINAGPGMRPHSFFIQFSLTAALN----- 674
            ||.:.:|..      |    :|.|||::.:::::.:......|.  ....:|..|:...|
Human   624 FTYATTEKVRRSIYSC----LDAQFYDDETVTVVLKDTVGREGR--DRLLVQLPLSLVYNSEDSA 682

  Fly   675 -------YSTQHRMGPLVKLSEATVSQSIHDIADGAAFKGLDGFSDMLAVSGSRKVATVLSDRKR 732
                   |||:     |.:...|..::::|........:.:.  :..:|.:|.|||:.|||...|
Human   683 EYQFTGTYSTR-----LDEQCSAIPTRTMHFEKHWRLLESMK--AQYVAGNGFRKVSCVLSSNLR 740

  Fly   733 KMTIFEMEIEEE----EDDTEMSQASFLDIS-KESVLAGVPDAEKQEA 775
            .:.:|||:|::|    |...|..:||...:. ||.||: ..:||.|:|
Human   741 HVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLS-ESEAENQQA 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	6..52	CDD:289649	13/46 (28%)
		WD40 repeat	20..54	CDD:293791	11/34 (32%)
		WD40 repeat	62..98	CDD:293791	11/36 (31%)
		ANAPC4	222..418	CDD:289651	57/198 (29%)
ANAPC4	NP_001273685.1	WD40 repeat	24..59	CDD:293791	11/34 (32%)
		ANAPC4_WD40	26..118	CDD:372368	27/93 (29%)
		WD40 repeat	68..102	CDD:293791	11/33 (33%)
		ANAPC4	232..431	CDD:372370	57/199 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158658
Domainoid	1	1.000	102	1.000	Domainoid score	I6903
eggNOG	1	0.900	-	-		E1_KOG4640
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40873
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3950
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49644
OrthoDB	1	1.010	-	-		D302186at33208
OrthoFinder	1	1.000	-	-		FOG0003724
OrthoInspector	1	1.000	-	-		oto88937
orthoMCL	1	0.900	-	-		OOG6_103906
Panther	1	1.100	-	-	LDO	PTHR13260
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770