Protein Alignment APC4 and cut20

DIOPT Version :10

• Sequence 1: NP_572522.2
• Gene: APC4 / 31835
• FlyBaseID: FBgn0052707
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: NP_001342965.1
• Gene: cut20 / 2542615
• PomBaseID: SPAC19G12.01C
• Length: 719
• Species: Schizosaccharomyces pombe
• Alignment Length: 783
• Identity: 150/783 - (19%)
• Similarity: 283/783 - (36%)
• Gaps: 206/783 - (26%)

  Fly    21 RMEWNNK-------------------MDLIAYGTEKGEVVIQRLNWQKI--VTFPTPGEDVRVRS 64
            :.||.|:                   |:|||..|....::..|.|.|:|  |.|    .|:....
pombe    13 KFEWINETNRVERVGSGLKRVILCPSMELIAILTCSNHLICCRSNSQRIWDVDF----HDLEATE 73

  Fly    65 LSWQMDETLLAVGYSNGKVALLDAESGTIISGLIYEDDIKKVYFSKAINSQENLGTYTCNVKDKH 129
            |.|..|..|:.||:.||::.::|:.:|.::.......|:..:..:.|:  ||.:      |.:|.
pombe    74 LCWNHDGNLIVVGFKNGELKIIDSSTGHLVEQRPASRDLAVLMITWAM--QETI------VNEKR 130

  Fly   130 RRFLPKLQPMTNIDPCLKTL-----DQKSF-PKGSPCFLVVIMRSG----KVHLL---------- 174
            ..|   |...|...|.|.||     :::.| .|....|.....|.|    ||.||
pombe   131 NDF---LFDATAYMPLLGTLPSSAKEERIFSSKAIAQFFEPRKREGENNKKVELLSILDERGIRY 192

  Fly   175 --------------LLGALQAG-----SI--DLTQHILHPHEFDVYDVRMNGDCNAIYALLRDGQ 218
                          |..||..|     ||  ||..|:|                     :.:.|.
pombe   193 INMFSSYKIGESDSLKSALNLGVPISHSITNDLAYHVL---------------------ICKGGT 236

  Fly   219 ELILLHFQNQVLQDCMAPMLELATHCAHILETKNYINDTQQCLTEAWETVQLE-------MDNKL 276
            .:.|......:|::.:..::::||....:.....|:.:....:.|.::.|...       .|..:
pombe   237 NISLKTLYMPLLKNDLGSIVDIATMSTRMQHLVRYLEEVLNAMYEEFDNVFKSEASFIKTFDALV 301

  Fly   277 TRYANSQPYGVISAHFLELHVF---GFATFEVEEFLFETLSEKGFKKIANSVDLSLSNLQSLVFK 338
            ::|:::..:.:    .|||:.|   |..:..::|::.|.:.::..|....::..|.::|  ::|.
pombe   302 SKYSDTTFFSL----QLELYQFIMNGIPSDLLKEWINERVGDRVLKNWERAMVNSYTSL--IIFC 360

  Fly   339 Q--LNGAAINMFYFLNTIAG---FGRMSHFFESLISPDVANEAMRACGGFVLKVHELQRTIDTLA 398
            |  :..|...:...|::..|   :|.|..  .:|:...:..:.:...|.....|......:....
pombe   361 QEFVIPACERLTVLLSSARGKSIWGHMKG--NTLLDAKLVEDCLATLGYLQNNVFSFLNCLFEEK 423

  Fly   399 YDMKLFHAWMIFTILRLSHQE----IPDDLVLTEEENI----------AMADFICAMEP-ELDD- 447
            ..||.|.:|:.:.|:..:..|    .|.:::....|.:          .:..:....:| :|.|
pombe   424 KYMKHFISWLNYAIVEFNTSEPSSIPPQEIIEHINETVIYIRHSLFRSKLTSYFMGTKPLQLRDP 488

  Fly   448 ---------RSDDEDELD---SQSQTPPPARSKFNLERVGQYLDNAYLTQLYPRDPVQLWEEMVT 500
                     ..||.:.:|   |........|..||:  :..|.......|......:.|:|.  |
pombe   489 DYYSLKDFANQDDSNSVDDFVSFKTLKESLRDSFNV--IFSYPSLTCQKQWLKTGDLVLFEG--T 549

  Fly   501 DNECLSNCKLFVPHDVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSSTVICNDLPPMEP--- 562
            |    .|....:|...|     :::::|:..   |.|.|.:|   |.:.|.::.|.:.|:..
pombe   550 D----WNVSSLIPKSCN-----EKNQLFSLF---FRKDTPNI---FLIISQLMENTMLPVSGCHF 599

  Fly   563 GEDHRDRDLVTCTYYVNEASRTDMLACTISGQEAMILEFSRAGDECVRCTRITLEPGLFTTSVSE 627
            |.|:.:. |.:.......|:..||.  .::|...:||  .:..::|..|
pombe   600 GLDYAEL-LGSSLLDFQPATVLDMK--LLNGSSILIL--GKLKEKCFLC---------------- 643

  Fly   628 DFCYLRFVDLQFYNESSLSILAQSINAGPGMRP-------HSF---FIQFSLTAALNYSTQHRMG 682
            :.| |..|.|.|:.....:....:|:..|.: |       |.|   |:..:|..||:.::.:  |
pombe   644 EIC-LADVPLTFFEHQQKNSYLDAISHLPFI-PLNSCLWLHEFEKDFLPSTLEYALSENSDY--G 704

  Fly   683 PLV 685
            .|:
pombe   705 VLI 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	22..111	CDD:403945	26/109 (24%)
		ANAPC4	222..418	CDD:463744	34/210 (16%)
cut20	NP_001342965.1	ANAPC4_WD40	33..122	CDD:403945	24/94 (26%)
		WD40 repeat	71..107	CDD:293791	10/35 (29%)
		ANAPC4	239..442	CDD:463744	34/210 (16%)