DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APC4 and cut20

DIOPT Version :9

Sequence 1:	NP_572522.2	Gene:	APC4 / 31835	FlyBaseID:	FBgn0052707	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_001342965.1	Gene:	cut20 / 2542615	PomBaseID:	SPAC19G12.01c	Length:	719	Species:	Schizosaccharomyces pombe

Alignment Length:	783	Identity:	150/783 - (19%)
Similarity:	283/783 - (36%)	Gaps:	206/783 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RMEWNNK-------------------MDLIAYGTEKGEVVIQRLNWQKI--VTFPTPGEDVRVRS 64
            :.||.|:                   |:|||..|....::..|.|.|:|  |.|    .|:....
pombe    13 KFEWINETNRVERVGSGLKRVILCPSMELIAILTCSNHLICCRSNSQRIWDVDF----HDLEATE 73

  Fly    65 LSWQMDETLLAVGYSNGKVALLDAESGTIISGLIYEDDIKKVYFSKAINSQENLGTYTCNVKDKH 129
            |.|..|..|:.||:.||::.::|:.:|.::.......|:..:..:.|:  ||.:      |.:|.
pombe    74 LCWNHDGNLIVVGFKNGELKIIDSSTGHLVEQRPASRDLAVLMITWAM--QETI------VNEKR 130

  Fly   130 RRFLPKLQPMTNIDPCLKTL-----DQKSF-PKGSPCFLVVIMRSG----KVHLL---------- 174
            ..|   |...|...|.|.||     :::.| .|....|.....|.|    ||.||
pombe   131 NDF---LFDATAYMPLLGTLPSSAKEERIFSSKAIAQFFEPRKREGENNKKVELLSILDERGIRY 192

  Fly   175 --------------LLGALQAG-----SI--DLTQHILHPHEFDVYDVRMNGDCNAIYALLRDGQ 218
                          |..||..|     ||  ||..|:|                     :.:.|.
pombe   193 INMFSSYKIGESDSLKSALNLGVPISHSITNDLAYHVL---------------------ICKGGT 236

  Fly   219 ELILLHFQNQVLQDCMAPMLELATHCAHILETKNYINDTQQCLTEAWETVQLE-------MDNKL 276
            .:.|......:|::.:..::::||....:.....|:.:....:.|.::.|...       .|..:
pombe   237 NISLKTLYMPLLKNDLGSIVDIATMSTRMQHLVRYLEEVLNAMYEEFDNVFKSEASFIKTFDALV 301

  Fly   277 TRYANSQPYGVISAHFLELHVF---GFATFEVEEFLFETLSEKGFKKIANSVDLSLSNLQSLVFK 338
            ::|:::..:.:    .|||:.|   |..:..::|::.|.:.::..|....::..|.::|  ::|.
pombe   302 SKYSDTTFFSL----QLELYQFIMNGIPSDLLKEWINERVGDRVLKNWERAMVNSYTSL--IIFC 360

  Fly   339 Q--LNGAAINMFYFLNTIAG---FGRMSHFFESLISPDVANEAMRACGGFVLKVHELQRTIDTLA 398
            |  :..|...:...|::..|   :|.|..  .:|:...:..:.:...|.....|......:....
pombe   361 QEFVIPACERLTVLLSSARGKSIWGHMKG--NTLLDAKLVEDCLATLGYLQNNVFSFLNCLFEEK 423

  Fly   399 YDMKLFHAWMIFTILRLSHQE----IPDDLVLTEEENI----------AMADFICAMEP-ELDD- 447
            ..||.|.:|:.:.|:..:..|    .|.:::....|.:          .:..:....:| :|.|
pombe   424 KYMKHFISWLNYAIVEFNTSEPSSIPPQEIIEHINETVIYIRHSLFRSKLTSYFMGTKPLQLRDP 488

  Fly   448 ---------RSDDEDELD---SQSQTPPPARSKFNLERVGQYLDNAYLTQLYPRDPVQLWEEMVT 500
                     ..||.:.:|   |........|..||:  :..|.......|......:.|:|.  |
pombe   489 DYYSLKDFANQDDSNSVDDFVSFKTLKESLRDSFNV--IFSYPSLTCQKQWLKTGDLVLFEG--T 549

  Fly   501 DNECLSNCKLFVPHDVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSSTVICNDLPPMEP--- 562
            |    .|....:|...|     :::::|:..   |.|.|.:|   |.:.|.::.|.:.|:..
pombe   550 D----WNVSSLIPKSCN-----EKNQLFSLF---FRKDTPNI---FLIISQLMENTMLPVSGCHF 599

  Fly   563 GEDHRDRDLVTCTYYVNEASRTDMLACTISGQEAMILEFSRAGDECVRCTRITLEPGLFTTSVSE 627
            |.|:.:. |.:.......|:..||.  .::|...:||  .:..::|..|
pombe   600 GLDYAEL-LGSSLLDFQPATVLDMK--LLNGSSILIL--GKLKEKCFLC---------------- 643

  Fly   628 DFCYLRFVDLQFYNESSLSILAQSINAGPGMRP-------HSF---FIQFSLTAALNYSTQHRMG 682
            :.| |..|.|.|:.....:....:|:..|.: |       |.|   |:..:|..||:.::.:  |
pombe   644 EIC-LADVPLTFFEHQQKNSYLDAISHLPFI-PLNSCLWLHEFEKDFLPSTLEYALSENSDY--G 704

  Fly   683 PLV 685
            .|:
pombe   705 VLI 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	6..52	CDD:289649	12/51 (24%)
		WD40 repeat	20..54	CDD:293791	13/53 (25%)
		WD40 repeat	62..98	CDD:293791	10/35 (29%)
		ANAPC4	222..418	CDD:289651	34/210 (16%)
cut20	NP_001342965.1	ANAPC4_WD40	33..122	CDD:315554	24/94 (26%)
		WD40 repeat	71..107	CDD:293791	10/35 (29%)
		ANAPC4	239..442	CDD:315556	34/210 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4640
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103906
Panther	1	1.100	-	-	LDO	PTHR13260
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10441
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930