DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APC4 and anapc4

DIOPT Version :9

Sequence 1:	NP_572522.2	Gene:	APC4 / 31835	FlyBaseID:	FBgn0052707	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_001135602.1	Gene:	anapc4 / 100216159	XenbaseID:	XB-GENE-968789	Length:	789	Species:	Xenopus tropicalis

Alignment Length:	822	Identity:	203/822 - (24%)
Similarity:	353/822 - (42%)	Gaps:	133/822 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MEWNNKMDLIAYGTEKGEVVIQRL-NWQKIVTFPTPGEDV--RVRSLSWQMDETLLAVGYSN-GK 82
            :.|:.|.||||...:.|||::.|| |.|::.:.| |.|:.  .|..|:|:.|..:||.|.:: .|
Frog    19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLP-PSENTGKEVTCLAWRPDGKILAFGLADTKK 82

  Fly    83 VALLDAESGTIISGLIYEDDIKKVYFSKAINSQENLGTYTCNVKDKHRRFLPKLQPMTNIDPCLK 147
            |.|.|.|....:.....|..|..:.:.: :..:.::.|...|.:|:....||||..:    |...
Frog    83 VVLCDVEKPESLHSFSLETPISCMQWME-VKVENSVLTSFYNAEDESNVLLPKLPAL----PKNY 142

  Fly   148 TLDQKSFPKGSPCFLVVIMRSGKVHLLLLGALQAGSIDLTQHILHPHEFDVYDV----RMNGDCN 208
            |...|.|.:.....::.::...:::.|:||. .:|.|::       :.:.:|.:    .:.|.|.
Frog   143 TATAKIFSEEKSDEILKLLGDVRLNALVLGG-DSGQIEI-------YAYGMYKIATISEVYGSCL 199

  Fly   209 AIYALLRDGQELILL------------HFQ--NQVLQDCMAPMLELATHCAHILETKNYINDTQQ 259
            .: .|..|.:.|.::            :||  ..:|.||:..:..:|....||.....|:..:..
Frog   200 GL-CLSNDLKSLSVVTELTTNSMPEITYFQLDTSLLSDCLPEVTRMARKFTHISTLLQYLQLSLT 263

  Fly   260 CLTEAWETVQLEMDNKLTRYANSQPYGV-ISAHFLELHVFGFATFEVEEFLFETLSEKGFKKIAN 323
            |:.||||.:.::||::||::...:.... :...|::|.::|.|:.|::..|...|:.||.||:..
Frog   264 CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMQLLLWGKASPELQALLMNQLTVKGLKKLGQ 328

  Fly   324 SVDLSLSNLQSLVFKQLNGAAINMFYFLNTIAGFGRMSHFFESL-ISPDVANEAMRACGGFVLKV 387
            ||:.|.|.:|.||...|...|..:.|.|:.:.|.......:|.| :......:|:.|.|.|:||.
Frog   329 SVESSYSTIQKLVISHLQSGAEALLYHLSELKGMALWKQKYEPLGLDAKAIEDAITAVGSFILKA 393

  Fly   388 HELQRTIDTLAYDMKLFHAWMIFTILRLSHQEI-PDDLVLTEEENIAMADFICAMEPELDDRSDD 451
            |||.:.||:...:.|.|..|:...:||:|...: |:...:|:::...:|||       |.:..::
Frog   394 HELLQVIDSGMKNFKAFFRWLYVAMLRMSEDHVLPELNKMTQKDITFVADF-------LTEHFNE 451

  Fly   452 EDELDSQSQTPPPARSK-FNLERVGQYL-DNAYLTQLYPRDPVQLWEEMVTDNECLSNCKLFVPH 514
            ..:|.:|       :.| ||:||||||| |...:....|......|...:..:..|....|..|:
Frog   452 APDLYNQ-------KGKYFNVERVGQYLKDEDDILMSPPNTEGNQWFSFLQSSTHLKESPLLFPY 509

  Fly   515 DVNLSLVQQRDKMFNAIDAVFHKPTESISGSFKVSSTVICNDLPPMEPGEDHRDRDLVTCTYYVN 579
            ....||...:.:|...||....||.:.|..|.:...   |..|..:...|:...| |::.....|
Frog   510 YPEKSLHYVKRQMEAVIDHCLTKPAQIIGMSVQQKR---CLPLYQVPASEEACPR-LISLPCLWN 570

  Fly   580 EASRT------DMLACTISGQEAMIL----EFSRAGDECVRCTRITLEPGLFTTSVSED------ 628
            :.|:.      .||..  |..:..:|    :.||:.::.:....|   .....:|.:||
Frog   571 DKSQNLHYVIFRMLES--SSSKVFLLRQPTDLSRSINDALLAVSI---GNSLNSSAAEDTETSSY 630

  Fly   629 FCYLRFVDLQFYNESSLSILAQSINAGPG------MRPHSFFIQFSLTA-ALNYSTQHRMGPLVK 686
            .|    :|.:||::..|:::.:..:...|      ..|.||......|. ...:.|..|:
Frog   631 SC----LDARFYDDDILTVVLRDNSEVEGKDRVLAQLPLSFLYSDEETEDGFTWDTSKRL----- 686

  Fly   687 LSEATVSQSIHDIADGAAFKGLDG--FSDM----LAVSGSRKVATVLSDRKRKMTIFEM------ 739
                  .:...||.....|....|  ..:|    ::|:|.||||.|||...|.:.:|||
Frog   687 ------EEQYQDIPTRTVFLESQGRLLENMKAHYVSVNGIRKVACVLSSNLRHVRVFEMDAEDDG 745

  Fly   740 EIEEEE------------------DDTEMSQASFLDISKESV 763
            |.||||                  ||.:.:.|..:|:::||:
Frog   746 EEEEEEILHSQDVTEEEEELNQSADDGQTNSAEAVDVTEESL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APC4	NP_572522.2	ANAPC4_WD40	6..52	CDD:289649	13/30 (43%)
		WD40 repeat	20..54	CDD:293791	13/32 (41%)
		WD40 repeat	62..98	CDD:293791	12/36 (33%)
		ANAPC4	222..418	CDD:289651	60/211 (28%)
anapc4	NP_001135602.1	ANAPC4_WD40	3..50	CDD:289649	13/30 (43%)
		WD40	<14..181	CDD:225201	46/175 (26%)
		WD40 repeat	17..52	CDD:293791	13/32 (41%)
		WD40 repeat	61..95	CDD:293791	12/33 (36%)
		WD40 repeat	103..150	CDD:293791	11/51 (22%)
		WD40 repeat	157..181	CDD:293791	5/31 (16%)
		ANAPC4	226..424	CDD:289651	60/197 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6387
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40873
Inparanoid	1	1.050	179	1.000	Inparanoid score	I3906
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302186at33208
OrthoFinder	1	1.000	-	-		FOG0003724
OrthoInspector	1	1.000	-	-		oto102803
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060