DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HP1b and CDY2A

DIOPT Version :9

Sequence 1:	NP_001162713.1	Gene:	HP1b / 31834	FlyBaseID:	FBgn0030082	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_004816.1	Gene:	CDY2A / 9426	HGNCID:	1810	Length:	541	Species:	Homo sapiens

Alignment Length:	272	Identity:	68/272 - (25%)
Similarity:	104/272 - (38%)	Gaps:	76/272 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EFSVERVEDKR-TVNGRTEYYLKWKGYPRSENTWEPVENL-DCPDLIANFEESLKNNKKETKK-- 63
            ||.||.:.||| ..||.|:|.::||||.:.::||||.::| :|...:.:|      |:::|:|
Human     5 EFEVEAIVDKRQDKNGNTQYLVRWKGYDKQDDTWEPEQHLMNCEKCVHDF------NRRQTEKQK 63

  Fly    64 -----------------RLSTSSTPESIRSKRKSFLEDDTEEQK--KLIGFERGL--EASKILG- 106
                             |.|.|:.....::..|:.:.|.....|  ||....:.:  :|:..|.
Human    64 KLTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDKHHRSKNCKLFAASKNVRRKAASTLSD 128

  Fly   107 --------------ATDSS-GHLMFLMKWKGSDHADLVPAKLANTRCPQVVIQFYEERL----TW 152
                          |.||. .|...:..::..:..|.:.|...:|    ||.:..|.:|    ..
Human   129 TKNMEIINSTIETLAPDSPFDHKKTVSGFQKLEKLDPIAADQQDT----VVFKVTEGKLLRDPLS 189

  Fly   153 HTGS-GNGNGNTNSVNLGSSGGLGSVGGSGA-GDDTAPGSV---------GTT----------GG 196
            |.|: ..|..|...::...|...|||..|.| |..|..|.|         |||          ||
Human   190 HPGAEQTGIQNKTQMHPLMSQMSGSVTASMATGSATRKGIVVLIDPLAANGTTDMHTSVPRVKGG 254

  Fly   197 GSNIDGGDEEDP 208
            ..||.......|
Human   255 QRNITDDSRGQP 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1b	NP_001162713.1	CHROMO	3..52	CDD:214605	22/50 (44%)
HP1b	NP_001162713.1	Chromo_shadow	100..151	CDD:279701	13/70 (19%)
CDY2A	NP_004816.1	CHROMO	5..58	CDD:214605	23/58 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..104		5/31 (16%)
		crotonase-like	287..483	CDD:119339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910