DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HP1b and CDYL

DIOPT Version :9

Sequence 1:	NP_001162713.1	Gene:	HP1b / 31834	FlyBaseID:	FBgn0030082	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001355054.1	Gene:	CDYL / 9425	HGNCID:	1811	Length:	598	Species:	Homo sapiens

Alignment Length:	232	Identity:	51/232 - (21%)
Similarity:	89/232 - (38%)	Gaps:	63/232 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VERVEDKR-TVNGRTEYYLKWKGYPRSENTWEPVENL-DCPDLIANFEESLKNNKKETKKRLSTS 68
            |||:.||| ...|:|||.::||||...::||||.::| :|.:.|.:|.......:||:....:..
Human    63 VERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKESTLTRTNR 127

  Fly    69 STPESI-----RSKRKSFLEDDTEEQKKLIGFERGLEASKILGATDSSGHLMFLMKWKGSDHADL 128
            ::|.:.     ||...:|  ..|..:..:||.:...:.|::..|:.
Human   128 TSPNNARKQISRSTNSNF--SKTSPKALVIGKDHESKNSQLFAASQ------------------- 171

  Fly   129 VPAKLANTRCPQVVIQFYEERLTWHTGSGNGNGNTNSVNLGSSGGLGSVGGSGAGDDTAPGSVGT 193
               |......|.:                   .:..:::|..||....|..|.....||
Human   172 ---KFRKNTAPSL-------------------SSRKNMDLAKSGIKILVPKSPVKSRTA------ 208

  Fly   194 TGGGSNIDGGDEEDPEPASPIGSINQDENIKPDESSE 230
                  :||...|.||...|:.. .|::.:.|:.::|
Human   209 ------VDGFQSESPEKLDPVEQ-GQEDTVAPEVAAE 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1b	NP_001162713.1	CHROMO	3..52	CDD:214605	22/47 (47%)
HP1b	NP_001162713.1	Chromo_shadow	100..151	CDD:279701	4/50 (8%)
CDYL	NP_001355054.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		6/12 (50%)
		Interaction with EZH2. /evidence=ECO:0000269\|PubMed:22009739	61..309		51/232 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..149		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..226		8/34 (24%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	362..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810