DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HP1b and CBX4

DIOPT Version :9

Sequence 1:	NP_001162713.1	Gene:	HP1b / 31834	FlyBaseID:	FBgn0030082	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_003646.2	Gene:	CBX4 / 8535	HGNCID:	1554	Length:	560	Species:	Homo sapiens

Alignment Length:	248	Identity:	52/248 - (20%)
Similarity:	74/248 - (29%)	Gaps:	110/248 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FSVERVEDKRTVNGRTEYYLKWKGYPRSENTWEPVENLDCPDLIANFEESLKNNKKETKKRLSTS 68
            |:||.:|.||...||.||.:||:|:....|||||.||:..|.|:..|:
Human    11 FAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQ----------------- 58

  Fly    69 STPESIRSKRKSFLEDDTEEQKKLIGFERGLEASKILGATDSSGHLMFLMKWKGSDHADLVPAKL 133
                            :.|.|::|:|:.:                       :|.....||
Human    59 ----------------NRERQEQLMGYRK-----------------------RGPKPKPLV---- 80

  Fly   134 ANTRCPQVVIQFYEERLTWHTG-SGNGNGNTNSVNLGSSGGLGSVGGSG---------------- 181
                   |.:..:..|....|| ..:...|...::||:.|     .|.|
Human    81 -------VQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQG-----KGQGHQYELNSKKHHQYQPH 133

  Fly   182 ----AGDDTAPGSVGTTGGGSN-----------------IDGGDEEDPEPASP 213
                ||....||..|......|                 ..||.:|.|.|..|
Human   134 SKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCP 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1b	NP_001162713.1	CHROMO	3..52	CDD:214605	23/47 (49%)
HP1b	NP_001162713.1	Chromo_shadow	100..151	CDD:279701	5/50 (10%)
CBX4	NP_003646.2	Interaction with BMI1	1..539		52/248 (21%)
		Involved in interaction with H3C15 and H3C1. /evidence=ECO:0000269\|PubMed:18927235	1..75		28/119 (24%)
		CHROMO	10..62	CDD:214605	23/83 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..152		13/64 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..243
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..404
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..528
		Involved in interaction with H3C15 and RNF2. /evidence=ECO:0000269\|PubMed:18927235	531..556
		CBX7_C	<538..559	CDD:319236
		Interaction with RNF2	540..560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920