DRSC/TRiP Functional Genomics Resources

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Protein Alignment HP1b and CBX5

DIOPT Version :9

Sequence 1:NP_001162713.1 Gene:HP1b / 31834 FlyBaseID:FBgn0030082 Length:240 Species:Drosophila melanogaster
Sequence 2:NP_001120793.1 Gene:CBX5 / 23468 HGNCID:1555 Length:191 Species:Homo sapiens


Alignment Length:162 Identity:88/162 - (54%)
Similarity:108/162 - (66%) Gaps:16/162 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EFSVERVEDKRTVNGRTEYYLKWKGYPRSENTWEPVENLDCPDLIANFEESLK------NN---- 57
            |:.||:|.|:|.|.|:.||.|||||:....|||||.:|||||:||:.|.:..|      ||    
Human    19 EYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPRE 83

  Fly    58 KKETKKRLST-SSTPESIRSKRKSFLEDDTEEQKKLIGFERGLEASKILGATDSSGHLMFLMKWK 121
            |.|:.||.|. |::.:.|:||:|....:|...     |||||||..||:|||||.|.||||||||
Human    84 KSESNKRKSNFSNSADDIKSKKKREQSNDIAR-----GFERGLEPEKIIGATDSCGDLMFLMKWK 143

  Fly   122 GSDHADLVPAKLANTRCPQVVIQFYEERLTWH 153
            .:|.||||.||.||.:|||:||.|||||||||
Human   144 DTDEADLVLAKEANVKCPQIVIAFYEERLTWH 175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HP1bNP_001162713.1 CHROMO 3..52 CDD:214605 28/48 (58%)
Chromo_shadow 100..151 CDD:279701 36/50 (72%)
CBX5NP_001120793.1 CD_HP1alpha_Cbx5 19..68 CDD:349298 28/48 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 70..117 14/51 (27%)
CSD_HP1alpha_Cbx5 116..173 CDD:349302 42/56 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 90 1.000 Domainoid score I7775
eggNOG 1 0.900 - - E1_KOG1911
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 176 1.000 Inparanoid score I4048
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52905
OrthoDB 1 1.010 - - D1628171at2759
OrthoFinder 1 1.000 - - FOG0000191
OrthoInspector 1 1.000 - - otm40254
orthoMCL 1 0.900 - - OOG6_104220
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X422
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.740

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