Protein Alignment HP1b and Cdyl

DIOPT Version :10

• Sequence 1: NP_572521.2
• Gene: HP1b / 31834
• FlyBaseID: FBgn0030082
• Length: 240
• Species: Drosophila melanogaster
• Sequence 2: NP_034011.1
• Gene: Cdyl / 12593
• MGIID: 1339956
• Length: 593
• Species: Mus musculus
• Alignment Length: 238
• Identity: 51/238 - (21%)
• Similarity: 92/238 - (38%)
• Gaps: 59/238 - (24%)

  Fly     2 AEFSVERVEDKR-TVNGRTEYYLKWKGYPRSENTWEPVENL-DCPDLIANFEESLKNNKKETKKR 64
            ||..||.:.||| ...|:|||.::||||...::||||.::| :|.:.|.:|.......:||....
Mouse    54 AETQVESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHNERQKEGSLA 118

  Fly    65 LSTSSTPESIR---SKRKSFLEDDTEEQKKLIGFERGLEASKILGATDSSGHLMFLMKWKGSDHA 126
            .::.::|.:.|   |:........|..:..::|.:...::|::|.|:.
Mouse   119 RASRASPSNARKQISRSTHSTLSKTNSKALVVGKDHESKSSQLLAASQ----------------- 166

  Fly   127 DLVPAKLANTRCPQVVIQFYEERLTWHTGSGNGNGNTNSVNLGSSGGLGSVGGSGAGDDTAPGSV 191
                 |......|.:                   .|..:::|..||....|..|
Mouse   167 -----KFRKNPAPSL-------------------ANRKNMDLAKSGIKILVPKS----------- 196

  Fly   192 GTTGGGSNIDGGDEEDPEPASPIGSINQDENIKPDESSELDNG 234
             ...|.:::||...|.||...|:.. ..::.:.|:.::|...|
Mouse   197 -PVKGRTSVDGFQGESPEKLDPVDQ-GAEDTVAPEVTAEKPTG 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HP1b	NP_572521.2	CD_HP1_like	3..52	CDD:349281	22/50 (44%)
		CSD	99..150	CDD:349275	5/50 (10%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Interaction with EZH2. /evidence=ECO:0000250|UniProtKB:Q9Y232	56..304		49/236 (21%)
		CD_CDY	57..106	CDD:349284	21/48 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..158		7/47 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..223		7/23 (30%)
		crotonase-like	339..535	CDD:119339
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589