DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HP1b and CDYL2

DIOPT Version :9

Sequence 1:	NP_001162713.1	Gene:	HP1b / 31834	FlyBaseID:	FBgn0030082	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	XP_011521168.1	Gene:	CDYL2 / 124359	HGNCID:	23030	Length:	540	Species:	Homo sapiens

Alignment Length:	242	Identity:	62/242 - (25%)
Similarity:	89/242 - (36%)	Gaps:	81/242 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VERVEDKR-TVNGRTEYYLKWKGYPRSENTWEPVEN-LDCPDLIANFEESLKNNKKETKKRLSTS 68
            |||:.||| ...|:.||.::||||..:|:||||..: |.|.:.|..| ..|..:|.:..|....|
Human    43 VERIVDKRKNKKGKWEYLIRWKGYGSTEDTWEPEHHLLHCEEFIDEF-NGLHMSKDKRIKSGKQS 106

  Fly    69 STPESIRSKRKSFLE------------DDTEEQKKLI---------GF-----ERGLEASKILG- 106
            ||.:.:|..|...:|            ..|..::|.|         |:     ..|..|:|.:.
Human   107 STSKLLRDSRGPSVEKLSHRPSDPGKSKGTSHKRKRINPPLAKPKKGYSGKPSSGGDRATKTVSY 171

  Fly   107 -ATDSSGHLMFLMK-WKGSDHADLVPAKLANTRCPQVVIQFYEERLTWHTGSGN----------- 158
             .|.|...:|.|.| ..|.::.|....|              :||   |.|:|:
Human   172 RTTPSGLQIMPLKKSQNGMENGDAGSEK--------------DER---HFGNGSHQPGLDLNDHV 219

  Fly   159 -----GNGNTNSVNLGSSGGLGSVGGSGAGDDTAPGSVGTTGGGSNI 200
                 |..:.|...| :..||||               ..|.||.|:
Human   220 GEQDMGECDVNHATL-AENGLGS---------------ALTNGGLNL 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1b	NP_001162713.1	CHROMO	3..52	CDD:214605	22/47 (47%)
HP1b	NP_001162713.1	Chromo_shadow	100..151	CDD:279701	12/53 (23%)
CDYL2	XP_011521168.1	CHROMO	40..89	CDD:214605	21/45 (47%)
CDYL2	XP_011521168.1	crotonase-like	286..482	CDD:119339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810