DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HP1b and Cbx4

DIOPT Version :9

Sequence 1:	NP_001162713.1	Gene:	HP1b / 31834	FlyBaseID:	FBgn0030082	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_031651.2	Gene:	Cbx4 / 12418	MGIID:	1195985	Length:	551	Species:	Mus musculus

Alignment Length:	243	Identity:	52/243 - (21%)
Similarity:	73/243 - (30%)	Gaps:	100/243 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FSVERVEDKRTVNGRTEYYLKWKGYPRSENTWEPVENLDCPDLIANFEESLKNNKKETKKRLSTS 68
            |:||.:|.||...||.||.:||:|:....|||||.||:..|.|:..|:
Mouse    11 FAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQ----------------- 58

  Fly    69 STPESIRSKRKSFLEDDTEEQKKLIGF-ERG-------------LEASKIL-GATDSSGHLMFLM 118
                            :.|.|::|:|: :||             ...|.:| |..|||.
Mouse    59 ----------------NRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSA------ 101

  Fly   119 KWKGSDHADLVPAKLANTRCPQVVIQFYEERLTWHTGS-GNGNGNTNSVNLGSSGGLGSVGGSGA 182
                                        :.|.....|: |.|.|:...:|..............:
Mouse   102 ----------------------------DNRAKLELGTQGKGQGHQYELNSKKHHQYQPHSKERS 138

  Fly   183 GDDTAPGSVGTTGGGSN-----------------IDGGDEEDPEPASP 213
            |....||..|......|                 ..||.:|.|.|..|
Mouse   139 GKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCP 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1b	NP_001162713.1	CHROMO	3..52	CDD:214605	23/47 (49%)
HP1b	NP_001162713.1	Chromo_shadow	100..151	CDD:279701	7/51 (14%)
Cbx4	NP_031651.2	CHROMO	10..62	CDD:214605	23/83 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..152		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..193		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..244
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..451
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920