Protein Alignment CG15365 and LZTS3

DIOPT Version :10

• Sequence 1: NP_001285030.1
• Gene: CG15365 / 31829
• FlyBaseID: FBgn0030077
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001354538.1
• Gene: LZTS3 / 9762
• HGNCID: 30139
• Length: 703
• Species: Homo sapiens
• Alignment Length: 890
• Identity: 187/890 - (21%)
• Similarity: 300/890 - (33%)
• Gaps: 326/890 - (36%)

  Fly    17 PPG-------TPPVLGGSGCSNLSLPSGKRGHKRSVSLENNAPLALRSTPSMGQSSLG--SPLLQ 72
            |||       |.||....|...|                    ||....|    |.||  .|.|.
Human    26 PPGLVMAKLETLPVRADPGRDPL--------------------LAFAPRP----SELGPPDPRLA 66

  Fly    73 FGQAAPGQGHSQGFHTGTLKSRQ----EQRRLSQKFGSHSNLDDEGVG--IGVGMGMGMGLQMRS 131
            .|....|..|:|.|...::.:|.    .|.......||.|....|..|  .....|:...|.:..
Human    67 MGSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNG 131

  Fly   132 KFQNIRQMFELSRSCVGGGGGDGRGGAAEEEAMQSLPATLPQQHQQQQQRRTTPIAGGSRHQQQ- 195
            :.:. ....::..:.||..||....|.:::         .|.|:::..            |..:
Human   132 ELRG-SDHTDVCGNVVGSSGGSSSSGGSDK---------APPQYREPS------------HPPKL 174

  Fly   196 -QQMGEAEQTSGNFLRPIAFKPIPFEPDYRIACQQQQQHQQQLQLQQQQQQQQQQQQQQQLQLQH 259
             ...|:.:|.|...:||.||||:          ..:..|..|.....|.....:.:|
Human   175 LATSGKLDQCSEPLVRPSAFKPV----------VPKNFHSMQNLCPPQTNGTPEGRQ-------- 221

  Fly   260 QQQQQHQQQHQHQHQQQHQSLQLPTEGGQAGGVAAERY-----GYGS------TPSLAPLPTASA 313
                                    ..||..||:...|.     |.||      ..||..|||.
Human   222 ------------------------GPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTY-- 260

  Fly   314 QKFGSTTDLRHLAARRRNHRLLQRCSNEDALTLDLLSTGSHDRPDG------------------- 359
                |::..:|||....:...:.|           :.|.|:....|
Human   261 ----SSSYSQHLAPLSASTSHINR-----------IGTASYGSGSGGSSGGGSGYQDLGTSDSGR 310

  Fly   360 ASSKSSGTV-------VGSSD-----------LTPSPSDSGISELEAALKDRDSELSYLRQAMEH 406
            |||||..:.       :||.:           ..|||| :.|.|||..|.:::.|::.||:::|.
Human   311 ASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSPS-ALIQELEERLWEKEQEVAALRRSLEQ 374

  Fly   407 NEKVIFQVQKDKEVYWEHETQRLRLFYEGQQRECQLKLRKMEQLLGLQQFQLKQHKLRQSEQVNR 471
            :|..:.||.::::..||.|...||....|:.::...:.::.:|.|.||..:|:|.|.:..|:..|
Human   375 SEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR 439

  Fly   472 LQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVCERNGEIALLKTQLKEAHLEINMKDHAIVSLK 536
            |.:|.:...|.....|::......::|:::|.||::.|||:|||.|||::..:::.|...||.|:
Human   440 LMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLR 504

  Fly   537 HSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEEQQQQQHPELQQQQQQQQQQQQQQQQQQQQQQ 601
                                             .|.::....|:::::|
Human   505 ---------------------------------SQLREGRASLREKEEQ---------------- 520

  Fly   602 QQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLKDQVIGALTSELAKLRKELSDLAIAHEYGEEP 666
                                         :::|:|    :.:|:.|.|           |.||
Human   521 -----------------------------LLSLRD----SFSSKQASL-----------ELGE-- 539

  Fly   667 CGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAVASPAAQVAPPAPSPAAHVATPSCAQELPKLD 731
                          .|:             |.|...||.....|| .|...:||  |..:..|
Human   540 --------------GEL-------------PAACLKPALTPVDPA-EPQDALAT--CESDEAK-- 572

  Fly   732 VLVQRLQLDQGQGTQQTLDTLIEESTTYAEDIAK-LRQKLDDFRLNLEL---------------- 779
                 ::...|.....:|.::..|:....|...: ||:::.  ||..||
Human   573 -----MRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVG--RLQAELAAERRARERQGASFAE 630

  Fly   780 EKRQWSAEKDKVLGYQKQLQAHYIQMYQK----LRCLDSAGAAVG 820
            |:|.|..||:||:.||||||..|::|||:    .|.|...|||.|
Human   631 ERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGG 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Fez1	<735..812	CDD:462015	28/97 (29%)
LZTS3	NP_001354538.1	SMC_prok_B	<349..>582	CDD:274008	72/364 (20%)
		Fez1	468..668	CDD:462015	67/333 (20%)