DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15365 and lzts3b

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_009301973.1	Gene:	lzts3b / 560221	ZFINID:	ZDB-GENE-110411-249	Length:	728	Species:	Danio rerio

Alignment Length:	840	Identity:	172/840 - (20%)
Similarity:	316/840 - (37%)	Gaps:	215/840 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SLPSGKRGHK----RSV----SLENNAPLALRSTPSMGQSSLGSPLLQFGQAAPGQGHSQGFHTG 89
            |:.||..|.:    :||    :|....||:.|. || .:|.....|......:.|....:|..:.
Zfish     3 SVGSGVAGEQEFAMKSVGTRTTLPRGPPLSRRG-PS-DRSCSAERLHPHPSTSEGSSDERGGSST 65

  Fly    90 TLKSRQEQRRLSQKFGSHSNLDD-EGVGIG--VGMGMGMGLQMRSKFQNIRQMFELSRSCVGGGG 151
            |.....|:.:|:.: ...:|||. ||...|  .|...|.|:.:           :...:.||.|.
Zfish    66 TTDRVLERGQLNME-RVPANLDALEGTAAGRRDGHRSGRGVSL-----------DACGNVVGHGA 118

  Fly   152 GDGRGGAAEEEAMQSLPATLPQQHQQQQQRRTTPIAGGSRHQQQQQMGEAEQTSGNFLRPIAFKP 216
            .....|||        |......:..::..||.|       :.....|:.||.:...:||.||||
Zfish   119 EKNHDGAA--------PLKSRDGNISKRDGRTPP-------KILTVSGKLEQNTSALVRPSAFKP 168

  Fly   217 IPFEPDYRIACQQQQQHQQQLQLQQQQQ-----------QQQQQQQQQQLQLQHQQQQQHQQQHQ 270
            :          ..:..|..|..:.|...           ....|...:|...:......:..|..
Zfish   169 V----------VPKSFHSMQNLVGQSGSGGGRSAGSGGGSDAPQSLCEQDSPERDPSGGNDGQGG 223

  Fly   271 HQHQQQHQSLQLPTEGGQAGGVAAERYGYGSTPSLAPLPTASAQKFGSTTDLRHLAARRRNHRLL 335
            .....::....|||..|.:       ..||...:|.||.       .||:.:..|::........
Zfish   224 MSDSGRNSLTSLPTYAGPS-------LSYGPAQALGPLS-------ASTSHINRLSSAAAPLEKG 274

  Fly   336 QRCSNEDALTLDLLSTGSHDRPDGASSKSSGTVVG----------SSDLTPSPS-DSGISELEAA 389
            ::...::.|::.          |...|.|..:.:.          |:.:.|||| |..|.:||..
Zfish   275 EKPKYQNGLSVS----------DSGQSSSGKSCLSYHRLCHLTEPSATVQPSPSTDDIIQDLEDR 329

  Fly   390 LKDRDSELSYLRQAMEHNEKVIFQVQKDKEVYWEHETQRLRLFYEGQQRECQLKLRKMEQLLGLQ 454
            |.:::.|:.::|:.::.:|..|.||.::|:..||.|.:.||..|.|:.::...:.::.:..|...
Zfish   330 LWEKEQEVIHMRRNLDQSEAAIAQVFEEKQRVWEREMEDLRQNYAGRLQQVTHRAQRTQHALQTH 394

  Fly   455 QFQLKQHKLRQSEQVNR-LQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVCERNGEIALLKTQL 518
            ..:|:|.|.|..|:::. |.|:.:|.|......::|.|.| .:||:::|.:|::.|||:|||.||
Zfish   395 IARLQQDKGRLQEEISALLAQREELERKCLDYRKEQADIL-PRLEETKWELCQKAGEISLLKQQL 458

  Fly   519 KEAHLEINMKDHAIVSLKHSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEEQQQQQHPELQQQQ 583
            :|:..|:..:....|:|:                                           .|.:
Zfish   459 RESQNEVTQRAGETVALR-------------------------------------------GQMK 480

  Fly   584 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLKDQVIGALTSELAK 648
            ....|.::::......:.....:.::.::.:.:||       :.|.::..|:|::: ...||:..
Zfish   481 DLNAQLKEREDTMIGLKDSYNSKSRELERCEGELK-------RTLAEVSMLRDKLV-VFESEVVG 537

  Fly   649 LRKELSDLAIAHEYGEEPCGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAVASPAAQVAPPAPS 713
            |::.|::|:                          |:.......:|.|.::....|...:|..|.
Zfish   538 LKRALNELS--------------------------CRSDHTAVLSSISGSSSLPWAGLHSPRTPE 576

  Fly   714 PAAHVATPSCAQELPKLDVLVQRLQLDQGQGTQQTLDTLIEESTTYAEDIAKLRQKLDDFRLNLE 778
            |               |.||        |...:..|....:|:....::..:||::|:..:..|.
Zfish   577 P---------------LSVL--------GSTVETFLSLQSDEAKAQRQEAGELRRQLERLQGELH 618

  Fly   779 LEKRQ--------------WSAEKDKVLGYQKQLQAHYIQMYQKLRCLDSAGAAVGQVEA 824
            |||:|              |..||::||.||.|||..|::..|:.:.|:.   .|||:.|
Zfish   619 LEKQQRERQALTFAQERHTWQDEKERVLKYQAQLQLSYVETLQRNQALEE---RVGQLGA 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	13/31 (42%)
lzts3b	XP_009301973.1	BAR	<323..465	CDD:299863	44/142 (31%)
lzts3b	XP_009301973.1	Fez1	440..670	CDD:284284	60/332 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4810
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24350
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19354
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5825
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.110