DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15365 and Lzts2

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001014269.2	Gene:	Lzts2 / 365468	RGDID:	1359249	Length:	670	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	124/552 - (22%)
Similarity:	212/552 - (38%)	Gaps:	177/552 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 PTEGGQAGGVAAERYGYGSTPSLA-PLPT----ASAQKFGSTTDLRHLAARRRNHRLLQRCSNED 342
            ||.....|.:.:...|.|..|..| .:||    :.:.:..|:.....|.||
  Rat   238 PTANSPGGHLPSHGPGRGPLPGPARGVPTGPSHSDSGRSSSSKSTGSLGAR-------------- 288

  Fly   343 ALTLDLLSTGSHDRPDGASSKSSGTVVGSSDLTPSPSDSGISE--LEAALKDRDSELSYLRQAME 405
             :...||.:|:...|   .|.|.|.........|.|||..:..  ||..|:||::||..||.:::
  Rat   289 -VAGGLLGSGARASP---GSSSGGDRSPPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSVD 349

  Fly   406 HNEKVIFQVQKDKEVYWEHETQRLRLFYEGQQREC-------QLKLRKMEQLLGLQQFQLKQHKL 463
            .:|..:.|....::..|           .|::.:|       ..::::.:|||.||.|||:|.|.
  Rat   350 ESEAAVCQAFGARQRRW-----------PGEREDCASHAQQATQRVQRAQQLLQLQVFQLQQEKR 403

  Fly   464 RQSEQVNRLQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVCERNGEIALLKTQLKEAHLEINMK 528
            :..:...:|.|:.:.........:::...|..:||:::|.||:::|||:|||.||||:..|:..|
  Rat   404 QLQDDFAQLLQEREQLERRCATFEREQQELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQK 468

  Fly   529 DHAIVSLKHSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEEQQQQQHPELQQQQQQQQQQQQQQ 593
            ...:|:|:.:...:.::            ...|:.:.:..:|..:.:..||:...|:.|:.:|:.
  Rat   469 GSELVALRVALREARAA------------LRVSEGRARGLQEAARARELELEACSQELQRYRQEA 521

  Fly   594 QQQQQQQQQQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLKDQVIGALTSELAKLRKELSDLAI 658
            :|.::                   |.:|                    |.:|.|.||:
  Rat   522 EQLRE-------------------KARH--------------------LDAEAAGLRE------- 540

  Fly   659 AHEYGEEPCGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAVASPAAQVAPPAPSPAAHVATPSC 723
                                                              ||.| ||  ...|..
  Rat   541 --------------------------------------------------PPVP-PA--TTDPFL 552

  Fly   724 AQELPKLDVLVQRLQLDQGQGTQQTLDTLIEESTTYAEDIAKLRQKL-------DDFRLNLELEK 781
            ..|..  :..|||    ...||..:|...:|          :|||:|       |:.|.:.|.|:
  Rat   553 LAESD--EAKVQR----AAAGTGGSLRAQVE----------RLRQELQREQRRGDEQRNSFEGER 601

  Fly   782 RQWSAEKDKVLGYQKQLQAHYIQMYQKLRCLD 813
            ..|.|||::|:.||||||.:|:|||::.|.|:
  Rat   602 LAWQAEKEQVIRYQKQLQHNYVQMYRRNRQLE 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	12/31 (39%)
Lzts2	NP_001014269.2	Required for centrosomal localization. /evidence=ECO:0000250	1..333		26/112 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..323		23/102 (23%)
		Fez1	440..636	CDD:284284	71/321 (22%)
		Sufficient for interaction with CTNNB1. /evidence=ECO:0000250	448..670		68/313 (22%)
		Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing. /evidence=ECO:0000250	451..670		66/310 (21%)
		DUF4763	503..>619	CDD:292582	44/230 (19%)
		Nuclear export signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03026	632..641		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJI9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109444
Panther	1	1.100	-	-	O	PTHR19354
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740