DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15365 and Lzts3

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_008760369.1	Gene:	Lzts3 / 280670	RGDID:	631327	Length:	766	Species:	Rattus norvegicus

Alignment Length:	893	Identity:	187/893 - (20%)
Similarity:	321/893 - (35%)	Gaps:	261/893 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAATHMAMPAHAV-----VPPPGTPPVLGGSGCSN---------LSLPSGKRGHKRSVSLENNAP 52
            |..:||| ||...     :..|..|.:.|...|.:         :..|||       :.:.....
  Rat    43 SRESHMA-PADLASEGPKLEDPPAPHLFGKGYCVSPLTSEIHYWIQCPSG-------LIMAKLET 99

  Fly    53 LALRSTPSMG--------QSSLG--SPLLQFGQAAPGQGHSQGFHTGTLKSRQEQRRLSQKF--- 104
            |.:|:.|...        .:.||  .|.|..|....|..|:|.|...::.:|.........|
  Rat   100 LPVRADPGRDPLLAFAPRPAELGPPDPRLTMGSVGGGVTHAQEFPMKSVGTRTGGGGSQGSFPGP 164

  Fly   105 ---GSHSNLDDEGVG--IGVGMGMGMGLQMRSKFQNIRQMFELSRSCVGGGGGDGRGGAAEEEAM 164
               ||.:|.:..|.|  ......:...|.:..:.:. ....::..:.||..||....|.:::
  Rat   165 RSSGSGTNRERPGPGRYPSEDKVLANSLYLNGELRG-SDHTDVCGNVVGSSGGSSSSGGSDK--- 225

  Fly   165 QSLPATLPQQHQQQQ---QRRTTPIAGGSRHQQQQQMGEAEQTSGNFLRPIAFKPIPFEPDYRIA 226
                  .|.|:::..   :..||             .|:.:|.|...:||.||||:
  Rat   226 ------APPQYREPNHPPKLLTT-------------SGKLDQCSEPLVRPSAFKPV--------- 262

  Fly   227 CQQQQQHQQQLQLQQQQQQQQQQQQQQQLQLQHQQQQQHQQQHQHQHQQQHQSLQLPTEGGQAGG 291
             ..:..|..| .|...|.....:.:|....|:...:               :|..:...||..||
  Rat   263 -VPKNFHSMQ-NLCPPQTNGTPEGRQGPAGLKGGLE---------------KSRTMTPAGGSGGG 310

  Fly   292 VAAERYGYGSTPSLAPLPTASAQKFGSTTDLRHLAARRRNHRLLQRCSN--------------ED 342
            ..::    ....||..|||.      |::..:|||....:...:.|...              :|
  Rat   311 GLSD----SGRNSLTSLPTY------SSSYSQHLAPLSASTSHINRIGTPGYSSGGGGGGSGYQD 365

  Fly   343 ALTLDLLSTGSHDRPDGASSK------------SSGTVVGSSDLTPSPSDSGISELEAALKDRDS 395
            ..|.|   :|......|:||.            .:|.:..::...|||| :.|.|||..|.:::.
  Rat   366 LGTSD---SGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPS-ALIQELEERLWEKEQ 426

  Fly   396 ELSYLRQAMEHNEKVIFQVQKDKEVYWEHETQRLRLFYEGQQRECQLKLRKMEQLLGLQQFQLKQ 460
            |::.||:::|.:|..:.||.::::..||.|...||....|:.::...:.::.:|.|.||..:|:|
  Rat   427 EVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQ 491

  Fly   461 HKLRQSEQVNRLQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVCERNGEIALLKTQLKEAHLEI 525
            .|.:..|:..:|.:|.:...|.....|::......::|:::|.||::.|||:|||.|||::..::
  Rat   492 DKKQLQEEAAQLIRQREELEDKVAACQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADV 556

  Fly   526 NMKDHAIVSLKHSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEEQQQQQHPELQQQQQQQQQQQ 590
            :.|...||.|:                                 .|.::....|:::::|
  Rat   557 SQKLSEIVGLR---------------------------------SQLREGRASLREKEEQ----- 583

  Fly   591 QQQQQQQQQQQQQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLKDQVIGALTSELAKLRKELSD 655
                                                    :::|:|    :..|:.|.|  |||:
  Rat   584 ----------------------------------------LLSLRD----SFGSKQASL--ELSE 602

  Fly   656 LAIAHEYGEEPCGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAVASPAAQVAPPAPSPA--AHV 718
                   ||.|               ..|.|      .:.:|..:..|...:|......|  ...
  Rat   603 -------GELP---------------PACLK------PALTPVDLVEPQEALASCESDEAKMRRQ 639

  Fly   719 ATPSCAQELPKLDVLVQRLQLDQG--QGTQQTLDTLIEESTTYAEDIAKLRQKLDDFRLNLELEK 781
            |..:.|..|..:|.     ::|.|  .||:    .|..|......::|..|:..:....:...|:
  Rat   640 AGVAAAASLVSVDG-----EVDAGGEGGTR----ALRREVGRLQAELAAERRARERQGASFAEER 695

  Fly   782 RQWSAEKDKVLGYQKQLQAHYIQMYQK----LRCLDSAGAAVGQVEAT 825
            |.|..||:||:.||||||..|::|||:    .|.|...|||.|....|
  Rat   696 RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSSTPT 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	11/31 (35%)
Lzts3	XP_008760369.1	DUF4200	423..525	CDD:290574	25/101 (25%)
Lzts3	XP_008760369.1	Fez1	531..730	CDD:284284	66/319 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJI9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto95989
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19354
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930