DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15365 and Lzts3

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_922936.3	Gene:	Lzts3 / 241638	MGIID:	2656976	Length:	700	Species:	Mus musculus

Alignment Length:	864	Identity:	184/864 - (21%)
Similarity:	309/864 - (35%)	Gaps:	258/864 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PGTPPVLGGSGCSNLSLPSGKRGHKRSVSLENNAPLALRSTPSMG--------QSSLG--SPLLQ 72
            |..|.:.|       ..|||       :.:.....|.:|:.|...        .|.||  .|.|.
Mouse    16 PPAPHLFG-------KCPSG-------LIMAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLT 66

  Fly    73 FGQAAPGQGHSQGFHTGTLKSRQEQRRLSQKF------GSHSNLDDEGVGIGVGMGMGMGLQMRS 131
            .|....|..|:|.|...::.:|.........|      ||.:|.:..|........:...|.:..
Mouse    67 MGSVGSGVTHAQEFPMKSVGTRTGGGGNQGSFPGPRSGGSGANRERPGRYPSEDKVLANSLYLNG 131

  Fly   132 KFQNIRQMFELSRSCVGGGGGDGRGGAAEEEAMQSLPATLPQQHQQQQ---QRRTTPIAGGSRHQ 193
            :.:. ....::..:.||..||....|.:::         .|.|:::..   :..||
Mouse   132 ELRG-SDHTDVCGNVVGSSGGSSSSGGSDK---------APPQYREPNHPPKLLTT--------- 177

  Fly   194 QQQQMGEAEQTSGNFLRPIAFKPIPFEPDYRIACQQQQQHQQQLQLQQQQQQQQQQQQQQQLQLQ 258
                .|:.:|.|...:||.||||:          ..:..|..| .|...|.....:.:|....|:
Mouse   178 ----SGKLDQCSEPLVRPSAFKPV----------VPKNFHSMQ-NLCPPQTNGTPEGRQGPAGLK 227

  Fly   259 HQQQQQHQQQHQHQHQQQHQSLQLPTEGGQAGGVAAERYGYGSTPSLAPLPTASAQKFGSTTDLR 323
            ....               :|..:...||..||::.     ....||..|||.      |::..:
Mouse   228 GGLD---------------KSRTMTPAGGSGGGLSD-----SGRNSLTSLPTY------SSSYSQ 266

  Fly   324 HLAARRRNHRLLQRCSNEDALTLDLLSTGSHDRPDG-----------ASSKSSGTV-------VG 370
            |||....:...:.|.....      .|:||.....|           |||||..:.       :|
Mouse   267 HLAPLSASTSHINRIGTAG------YSSGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLG 325

  Fly   371 SSD-----------LTPSPSDSGISELEAALKDRDSELSYLRQAMEHNEKVIFQVQKDKEVYWEH 424
            |.:           ..|||| :.|.|||..|.:::.|::.||:::|.:|..:.||.::::..||.
Mouse   326 SGEGGNGGLPFAACSPPSPS-ALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWER 389

  Fly   425 ETQRLRLFYEGQQRECQLKLRKMEQLLGLQQFQLKQHKLRQSEQVNRLQQQLDLARDSSQGLQQQ 489
            |...||....|:.::...:.::.:|.|.||..:|:|.|.:..|:..:|.:|.:...|.....|::
Mouse   390 ELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAVCQKE 454

  Fly   490 VDALRHQLEDSEWRVCERNGEIALLKTQLKEAHLEINMKDHAIVSLKHSSNRSSSSSNSNSNKSC 554
            ......::|:::|.||::.|||:|||.|||::..:::.|...||.|:
Mouse   455 QADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLR------------------ 501

  Fly   555 DTNTSQSQPKQQAKEEQQQQQHPELQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLKQ 619
                           .|.::....|:::::|
Mouse   502 ---------------SQLREGRASLREKEEQ---------------------------------- 517

  Fly   620 QHQPDQQQLQKIITLKDQVIGALTSELAKLRKELSDLAIAHEYGEEPCGRYTRLKQQLDNLNEIC 684
                       :::|:|    :..|:.|.|  |||:       ||.|               ..|
Mouse   518 -----------LLSLRD----SFGSKQASL--ELSE-------GELP---------------PAC 543

  Fly   685 QKTRKYTTTSASPTAVASPAAQVAPPAPSPA--AHVATPSCAQELPKLDVLVQRLQLDQGQGTQQ 747
            .|      .:.:|..:..|...:|......|  ...|..:.|..|..:|..|:.    .|:|..:
Mouse   544 LK------PALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVEA----GGEGGTR 598

  Fly   748 TLDTLIE--ESTTYAEDIAKLRQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQAHYIQMYQK-- 808
            .|...:.  ::...||..|:.||     ..:...|:|.|..||:||:.||||||..|::|||:
Mouse   599 ALRREVGRLQAELAAERRARERQ-----GASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQ 658

  Fly   809 --LRCLDSAGAAVGQVEAT 825
              .|.|...|||.|....|
Mouse   659 QLERRLRERGAAGGSSTPT 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	11/31 (35%)
Lzts3	NP_922936.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..121		18/80 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..188		12/77 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..344		33/174 (19%)
		Smc	<346..>539	CDD:224117	59/283 (21%)
		Fez1	465..664	CDD:369093	67/319 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..700		7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833475
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJI9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto92424
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19354
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5825
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960