DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15365 and Lzts2

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001123997.1	Gene:	Lzts2 / 226154	MGIID:	2385095	Length:	671	Species:	Mus musculus

Alignment Length:	698	Identity:	146/698 - (20%)
Similarity:	252/698 - (36%)	Gaps:	229/698 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 PQQHQQQQQR------RTTPIAGGSRHQQQQQMGEAEQTSGNFLRPIAFKPI-------PFEPDY 223
            |::||.....      :..|::|......::.:          :||.||||:       |..|.:
Mouse   110 PREHQAHNAHLRGPPPKLIPVSGKLEKNMEKIL----------IRPTAFKPVLPKPRGAPSLPGF 164

  Fly   224 ---RIA-CQQQQQHQQQL---QLQQQQQQQQQQQQQQQLQLQHQQQQQHQQQHQHQHQQQHQSLQ 281
               |.| ....|....||   ...............:.|.|
Mouse   165 LGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAL------------------------ 205

  Fly   282 LPTEGGQAGGVAAERYGYGSTPSLAPLPTASAQKFGSTTDL--RHLAARRRNHRLLQRCSNEDAL 344
                .|.|.|..:.........||:.|||.|......||:.  .||.:.......|...:..
Mouse   206 ----SGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTNSPGGHLPSHGPGRGALPGPARG--- 263

  Fly   345 TLDLLSTG-SH-DRPDGASSKSSGTV----------------VGSSD---------LTPSPSDSG 382
                :.|| || |....:||||:|::                .|||.         ..|.|||..
Mouse   264 ----VPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEA 324

  Fly   383 ISE--LEAALKDRDSELSYLRQAMEHNEKVIFQVQKDKEVYWEHETQRLRLFYEG-----QQREC 440
            :..  ||..|:||::||..||.:|:.:|..:.|....::..|..|        .|     |.::.
Mouse   325 LLHCVLEGKLRDREAELQQLRDSMDESEATVCQAFGARQRRWPRE--------RGEDCAAQAQQA 381

  Fly   441 QLKLRKMEQLLGLQQFQLKQHKLRQSEQVNRLQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVC 505
            ..::::.:|||.||.|||:|.|.:..:...:|.|:.:.........:::...|..:||:::|.||
Mouse   382 TQRVQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQRELGPRLEETKWEVC 446

  Fly   506 ERNGEIALLKTQLKEAHLEINMKDHAIVSLKHSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEE 570
            :::|||:|||.||||:..|:..|...:|:|:.:...:.::
Mouse   447 QKSGEISLLKQQLKESQAELVQKGSELVALRVALREARAT------------------------- 486

  Fly   571 QQQQQHPELQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLK 635
                    |:..:.:.:..|:..:.::|:.:...|:.|:.:|:.::|:::
Mouse   487 --------LRVSEGRARGLQEAARAREQELEACSQELQRYRQEAERLREK--------------- 528

  Fly   636 DQVIGALTSELAKLRKELSDLAIAHEYGEEPCGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAV 700
               .|.|.:|.:.||.
Mouse   529 ---AGHLDAEASGLRD------------------------------------------------- 541

  Fly   701 ASPAAQVAPPAPSPAAHVATPSCAQELPKLDVLVQRLQLDQGQGTQQTLDTLIEESTTYAEDIAK 765
                    ||.| ||  ...|....|..  :..|||.....|...:..::.|.:|       :.:
Mouse   542 --------PPVP-PA--TTDPFLLAESD--EAKVQRAAAGAGGSLRAQVERLRQE-------LQR 586

  Fly   766 LRQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQAHYIQMYQKLRCLD 813
            .:::.|:.|.:.|.|:..|.|||::|:.||||||.:|||||::.|.|:
Mouse   587 EQRRGDEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLE 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	12/31 (39%)
Lzts2	NP_001123997.1	Required for centrosomal localization. /evidence=ECO:0000250	1..333		53/267 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..324		42/209 (20%)
		GAS	<404..476	CDD:372757	21/71 (30%)
		Fez1	441..637	CDD:369093	64/314 (20%)
		Sufficient for interaction with CTNNB1. /evidence=ECO:0000250	449..671		61/306 (20%)
		Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing. /evidence=ECO:0000250	452..671		59/303 (19%)
		Nuclear export signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03026	633..642		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJI9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109444
Panther	1	1.100	-	-	O	PTHR19354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5825
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770