DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15365 and lzts3

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_002936402.1	Gene:	lzts3 / 100485228	XenbaseID:	XB-GENE-961223	Length:	654	Species:	Xenopus tropicalis

Alignment Length:	799	Identity:	156/799 - (19%)
Similarity:	310/799 - (38%)	Gaps:	202/799 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LENNAPL---ALRSTPS----MGQSSLGSPLLQFGQAAPGQGHSQGFHTGTLKSRQEQRRLSQKF 104
            ||:.:.|   |.:|..|    :.:||...|....|....|..:.|.|...::.:| .|..|.|..
Frog     4 LESRSVLSDTAYQSQESFHSFVSRSSESPPHCTMGSVGSGVANDQEFPMKSVGTR-TQNSLKQND 67

  Fly   105 GSHSNLDDEGVGIGVGMGMGMGLQMRSKFQNIRQMFELSRSCVGGGGGDGRGGAAEEEAMQSLPA 169
            .|.:...                   :::....::::|.::.    |....|...:.|.|::.|.
Frog    68 SSRNGYS-------------------NRYSGEEKIYKLDKNT----GMYINGEQRKCEKMKTDPC 109

  Fly   170 ---------TLPQ--QHQQQQQRRTTPIAGGSRHQQQQQMGEAEQTSGNFLRPIAFKPIPFEPDY 223
                     .:||  |:::....:..|::           |:.||::...:||.||||:
Frog   110 GNVSANNEKNMPQAAQYRESNPPKIVPVS-----------GKLEQSNEPLVRPSAFKPV------ 157

  Fly   224 RIACQQQQQHQQQLQLQQQQQQQQQQQQQQQLQLQHQQQQQHQQQHQHQHQQQHQSLQLPTEGGQ 288
                ..:..|..|...........:.::.......:..........:..|.:....:...::.|:
Frog   158 ----VPKNFHSMQNLCPPLNNGVSENRKSSNHGNSNSPAAMKNSLEKSSHNRSSNQVGGLSDSGR 218

  Fly   289 AGGVAAERYGYGSTPSLAPLPTASAQKFGSTTDLRHLAARRRNHRLLQRCSNEDALTLDLLSTGS 353
            ....:...||.|.:..:.|:..:::          |:      :|:......::.:..:..:|..
Frog   219 NSLTSLPTYGSGYSQHVGPMSASTS----------HI------NRIGTSYIEKNIVGYNGTTTSE 267

  Fly   354 HDRPDGASSKSSGTVVGSSDLTP--SP-SDSGISELEAALKDRDSELSYLRQAMEHNEKVIFQVQ 415
            ..|....|:.|...:...::..|  || ||..|.:||..|.:::.|:..::::::.:|..||||.
Frog   268 SGRSSSKSASSFSRLNHLNETLPFHSPSSDDIIQDLEDRLWEKEQEVIQMKRSLDKSEAAIFQVF 332

  Fly   416 KDKEVYWEHETQRLRLFYEGQQRECQLKLRKMEQLLGLQQFQLKQHKLRQSEQVNRLQQQLDLAR 480
            ::|:..||.|.:.||..|..:.::...|.::.:|.|.||.|:|:|.|.:..|.|.:|.|:.:...
Frog   333 EEKQKIWEREMEDLRQNYANKLQQVSKKAQRAQQALQLQIFKLQQEKKKLQEDVAQLLQEREEME 397

  Fly   481 DSSQGLQQQVDALRHQLEDSEWRVCERNGEIALLKTQLKEAHLEINMKDHAIVSLKHSSNRSSSS 545
            ......:::......::|:::|.||::.|||:|||.|||:...:::.|.:.||.|:
Frog   398 KKCMAFKKEQAEFLPKIEETKWEVCQKAGEISLLKQQLKDCQADLSQKLNEIVGLR--------- 453

  Fly   546 SNSNSNKSCDTNTSQSQPKQQAKEEQQQQQHPELQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 610
                      |...:::...:.||||..........:....:..:.:.|::|.:.||.:::..|.
Frog   454 ----------TQLKEAKAFLREKEEQIASIKDSYSSKSVSLEICENEMQRKQSEAQQMKEKLSQC 508

  Fly   611 QQQQQQLKQQ-----HQPDQQQLQKIITLKDQVIGALTSELAKLRKELSDLAIAHEYGEEPCGRY 670
            :|:...||:.     ..|...:|.:  .|:|.:  |..|:.||::::..|..|:
Frog   509 EQEISSLKEALASLGQNPYTIELNE--KLRDTL--ACESDEAKMKRQNEDSVIS----------- 558

  Fly   671 TRLKQQLDNLNEICQKTRKYTTTSASPTAVASPAAQVAPPAPSPAAHVATPSCAQELPKLDVLVQ 735
              ||:.::.|                                                :|::.|:
Frog   559 --LKKDIERL------------------------------------------------QLELTVE 573

  Fly   736 RLQLDQGQGTQQTLDTLIEESTTYAEDIAKLRQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQA 800
            :.|.|     ||.:|                          .|.|:..|..||:||:.||||||.
Frog   574 KQQRD-----QQVVD--------------------------FEEERHTWQEEKEKVIKYQKQLQL 607

  Fly   801 HYIQMYQKLRCLDSAGAAV 819
            :|::||||.:.|:...|.:
Frog   608 NYVEMYQKNQQLEQRMAEI 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	10/31 (32%)
lzts3	XP_002936402.1	SMC_prok_A	<300..>516	CDD:274009	58/234 (25%)
lzts3	XP_002936402.1	Fez1	417..623	CDD:399656	68/320 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4689
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto102728
Panther	1	1.100	-	-	O	PTHR19354
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5825
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.180