DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15365 and lzts2b

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_017214089.1	Gene:	lzts2b / 100005471	ZFINID:	ZDB-GENE-030131-9587	Length:	608	Species:	Danio rerio

Alignment Length:	849	Identity:	163/849 - (19%)
Similarity:	300/849 - (35%)	Gaps:	298/849 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VPPPGTPPVLGGSGCSNLSLPSGKRGHKRS-VSLENNAPLALRSTPSMGQSSLGSPLLQFGQAAP 78
            :.|...|..||..|..:..:|:.....:|: :.:..|   ..:.||..|:.....|  |.|...|
Zfish    11 IDPRLHPAELGAMGAVSSMIPNHITYPERADIEVSTN---FRKGTPDSGRLLWDVP--QAGSRTP 70

  Fly    79 GQ------GHSQGFHTGTLKSRQEQRRLSQKFGSHSNL----DDEGVGIGVGMGMGMGLQMRSKF 133
            |.      |.::||.|.:.              ||.:|    :|..:.:|:
Zfish    71 GNRRRAIVGRAKGFGTRSY--------------SHEDLIRDWNDNHMDVGM-------------- 107

  Fly   134 QNIRQMFELSRSCVGGGGGDGRGGAAEEEAMQSLPATLPQQHQQQQQRRTTPIAGGSRHQQQQQM 198
                      .|.|.|                  |..|            .|::|......||.:
Zfish   108 ----------TSAVDG------------------PPKL------------VPVSGQLERNIQQAI 132

  Fly   199 GEAEQTSGNFLRPIAFKP-IPFEPDYRIACQQQQQHQQQLQLQQQQQQQQQQQQQQQLQLQHQQQ 262
                      :||.|||| ||                        :.:...|....:|.......
Zfish   133 ----------IRPTAFKPVIP------------------------KSRNTAQFLSPRLGTGLSGS 163

  Fly   263 QQHQQQHQHQHQQ-QHQSLQLPTE-GGQAGGVAAERYGYGSTP--SLAPLPTASAQKFGSTTDLR 323
            |.:..:.....:. .|.:|:..:. .|....:.::.:....||  ||..||..:.|...|:
Zfish   164 QGNLSRFSPDAEDVSHATLERRSSYSGARNALFSQSFTMTETPRGSLTNLPAYTQQHVESS---- 224

  Fly   324 HLAARRRNHRLLQRCSNEDALTLDLLSTGSHDRPDGASSKSSGTVVGSSDLT-------PSPS-- 379
                     :|...||:              |....:||||:|::.|...:.       |||.
Zfish   225 ---------KLPGNCSS--------------DSGRSSSSKSTGSLGGRGHMLSDRGSAGPSPPPI 266

  Fly   380 ---DSGISELEAALKDRDSELSYLRQAMEHNEKVIFQVQKDKEVYWEHETQRLRLFYEGQQRECQ 441
               ::.:.:||..|::|:.||..||:.::.||..|.||.::::...|.|.:..|.....:.::..
Zfish   267 EAYEAIVRDLEEKLRERELELQRLRENLDENEAAICQVYEERQKRTELEIEEFRQMCAAKMQKAS 331

  Fly   442 LKLRKMEQLLGLQQFQLKQHKLRQSEQVNRLQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVCE 506
            .|.::.:|:|.:|.||::|.|.:..|::.::.::.....:.....:::...|..:||:::|.||:
Zfish   332 QKAQREQQMLQMQVFQMQQEKKKHQEEMTQILKERQRLEERCSSFEREHTQLGPRLEETKWEVCQ 396

  Fly   507 RNGEIALLKTQLKEAHLEINMKDHAIVSLKHSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEEQ 571
            ::|||:|||.|||:...::..:...:|:::                                 .|
Zfish   397 KSGEISLLKQQLKDLQADLAQRVGELVTVR---------------------------------GQ 428

  Fly   572 QQQQHPELQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLKD 636
            .::...|||..|.|.|:.....:.:..:.:..|.:.|:::.:.:.|:::
Zfish   429 LREVRSELQTSQNQLQEANTTSRTRILELEVCQNELQRRKSENELLREK---------------- 477

  Fly   637 QVIGALTSELAKLRKELSDLAIAHEYGEEPCGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAVA 701
              |..|..:.:::|..|:..|         .|:..||.::.:.|     ||
Zfish   478 --ISHLEEDSSQMRDALNAAA---------SGKEQRLAEETEEL-----KT-------------- 512

  Fly   702 SPAAQVAPPAPSPAAHVATPSCAQELPKLDVLVQRLQLDQGQGTQQTLDTLIEESTTYAEDIAKL 766
                                                       ::|..|.|..|       :|..
Zfish   513 -------------------------------------------SRQQADRLKAE-------LAYE 527

  Fly   767 RQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQAHYIQMYQKLRCLDSAGAAVG-------QVEA 824
            ||:..|.....|.|::.|..|||||:.||||||.:|:|||::.|.|:.:...:.       |.:.
Zfish   528 RQRFSDQAAAFESERKSWEEEKDKVIRYQKQLQQNYVQMYKRNRDLERSLRELSLELESREQDDD 592

  Fly   825 TSGN 828
            :|||
Zfish   593 SSGN 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	12/31 (39%)
lzts2b	XP_017214089.1	DUF4200	288..372	CDD:290574	19/83 (23%)
		Fez1	390..577	CDD:284284	62/315 (20%)
		DUF3166	464..527	CDD:288256	18/158 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CJI9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4810
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24350
orthoMCL	1	0.900	-	-		OOG6_109444
Panther	1	1.100	-	-	O	PTHR19354
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880