DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and DGKI

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_001375021.1	Gene:	DGKI / 9162	HGNCID:	2855	Length:	1078	Species:	Homo sapiens

Alignment Length:	1180	Identity:	441/1180 - (37%)
Similarity:	613/1180 - (51%)	Gaps:	214/1180 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 LPLDPGSPPISPCSSNSGRLPALAPIIST----PCS-SADADDAGAAMGLPVRARRRSISRQEAI 419
            |||        |.:....|.||.|...:.    ||| :|.|..|.|..|.
Human    11 LPL--------PAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGA--------------- 52

  Fly   420 FVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATC--GSPGAAGGSGASSSHHNAFVVR 482
             :.|:.::.|.           |.:  |..|....|...:|  |:.|.|...||.|:
Human    53 -MNPSSSAGEE-----------KGA--TGGSSSSGSGAGSCCLGAEGGADPRGAGSA-------- 95

  Fly   483 DIYLMVPDLKRDRAASVD---SCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTD 544
                     ....||::|   :...|....|..|:|:             |.|..:.|
Human    96 ---------AAAGAAALDEPAAAGQKEKDEALEEKLR-------------NLTFRKQV------- 131

  Fly   545 EQARYKALSMTG---------STVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYWKPTSASG 600
              :..||:|..|         .::..|:|      .::.| |...||:||||.|||.|..|:.||
Human   132 --SYRKAISRAGLQHLAPAHPLSLPVANG------PAKEP-RATLDWSENAVNGEHLWLETNVSG 187

  Fly   601 DLCCLNEE-C----IKSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQYREQTTTH 660
            |||.|.|| |    .||..|.||:.|::|.|..||..: ||....||||:|:.|.|..|| ....
Human   188 DLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQL-EKINFRCKPTFREGGSRSPRE-NFVR 250

  Fly   661 HHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECR 725
            ||||||:.::||||||||.|..|.:     |.||||||::|:||.:.:|||..||....|.|.|.
Human   251 HHWVHRRRQEGKCKQCGKGFQQKFS-----FHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCS 310

  Fly   726 LGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQK- 789
            ||.:|.:||||:||:|:....|   |::.||                      :.||:|..::|
Human   311 LGAHAAVIVPPTWIIKVKKPQN---SLKASN----------------------RKKKRTSFKRKA 350

  Fly   790 ---GKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPK 851
               |.|::.:.|.|::|||.||.:.|::||:|||||||||.|:|..|...|||||||||:|.|||
Human   351 SKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPK 415

  Fly   852 MGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIF 916
            ..|:::||.||||:|||||||||||:||:||::|  |.|.|.||||||||||||||.|.|||
Human   416 DALELYRKVPNLRILACGGDGTVGWILSILDELQ--LSPQPPVGVLPLGTGNDLARTLNWGG--- 475

  Fly   917 FQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVDAH 981
              ||||||:.|||.::.....|.:|||.:.|..|.|:..:.::.....:||||.|||||.|.|||
Human   476 --GYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAH 538

  Fly   982 IALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCH 1046
            :.|||||:|||:||:||||.||||:|......|.:.|..|:||:.|.:.|||.|.|.|:::....
Human   539 VTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQ 603

  Fly  1047 AVLFLNIPSYGGGTHPW---NDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKAR 1108
            .::|||||.|..||.||   .|.........|||.:||:|.|...|..||.|.||..:.|||:..
Human   604 CIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVM 668

  Fly  1109 IITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNPL---------------- 1157
            ::|.::||||||||.||:.|::|.|.|.|:|.|:.|.|.......:|.:
Human   669 LLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQTADLRRVSAPPG 733

  Fly  1158 ---------EKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLN----- 1208
                     :::::.:.::::|.||.:|||||.||:.:..||.:.:...||||..|..::
Human   734 SFTIPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASIPLGILVVRGDCDLETCRMYIDRLQED 798

  Fly  1209 -----------------TKFEESISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDEL 1256
                             |.|..::|..::|..|||:|:.:|:.::||||:|||||::.:|:.||:
Human   799 LQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISQDEI 863

  Fly  1257 YILDHE------AATMPQTPD---QERSFAAFSQRQAQNERRQMDQAQGR-GPGSTDEDLQIGSK 1311
            :|||.:      |.|.|..||   ::.|..:.....|..:|...|...|. .|...|.||:..|.
Human   864 FILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSH 928

  Fly  1312 PIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVK 1376
            . :|:  :||:..: ..|||.|..:|||..|...::.|.||.....:..:.||:|.|..:.:|||
Human   929 S-RVL--QSPVSSE-DHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVK 989

  Fly  1377 YIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNAN 1441
            ||:......|::|||.|.|:||||.||.|..|.:|.:||.|||.|...||.|.||...|......
Human   990 YILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDP 1054

  Fly  1442 EIATYLESKQ 1451
            ::|.||||:|
Human  1055 DLAAYLESRQ 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	24/53 (45%)
		C1_1	661..725	CDD:278556	33/63 (52%)
		LCB5	813..1140	CDD:224513	174/329 (53%)
		DAGKc	814..942	CDD:214487	81/127 (64%)
		DAGKa	969..1123	CDD:214486	76/156 (49%)
		ANK	1329..1447	CDD:238125	48/117 (41%)
		ANK repeat	1329..1356	CDD:293786	11/26 (42%)
		Ank_2	1330..1425	CDD:289560	40/94 (43%)
		ANK repeat	1358..1391	CDD:293786	11/32 (34%)
		ANK repeat	1393..1425	CDD:293786	17/31 (55%)
		Ank_2	1399..>1459	CDD:289560	25/53 (47%)
DGKI	NP_001375021.1	C1_DGKiota_rpt1	168..240	CDD:410400	37/72 (51%)
		C1_DGKiota_rpt2	249..323	CDD:410446	41/78 (53%)
		DAGKc	378..499	CDD:214487	81/127 (64%)
		DAGKa	526..683	CDD:214486	76/156 (49%)
		ANKYR	874..1075	CDD:223738	71/195 (36%)
		ANK repeat	938..969	CDD:293786	11/31 (35%)
		Ank_2	943..1038	CDD:403870	40/94 (43%)
		ANK repeat	971..1004	CDD:293786	11/32 (34%)
		ANK repeat	1006..1038	CDD:293786	17/31 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155655
Domainoid	1	1.000	175	1.000	Domainoid score	I3648
eggNOG	1	0.900	-	-		E1_KOG0782
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	679	1.000	Inparanoid score	I717
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143806at33208
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm40401
orthoMCL	1	0.900	-	-		OOG6_104636
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2485
SonicParanoid	1	1.000	-	-		X1934
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790