Protein Alignment rdgA and DGKD

DIOPT Version :10

• Sequence 1: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_054200226.1
• Gene: DGKD / 8527
• HGNCID: 2851
• Length: 1238
• Species: Homo sapiens
• Alignment Length: 1390
• Identity: 285/1390 - (20%)
• Similarity: 448/1390 - (32%)
• Gaps: 567/1390 - (40%)

  Fly   431 VSHEEVDNSNTKSSVDTADSLDEASTMATC------GSPGAAG------GSGASSSHHNAFVVRD 483
            |:|:::.:.....:|  |.:|...|....|      |:||.||      .:||....      .|
Human    10 VTHQKLGSQGVHLAV--AGALQGHSCCCGCTVPLLPGNPGLAGVTSSTTWTGAEGQR------MD 66

  Fly   484 IYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDEQAR 548
            :....|   |.|...:........:|:    .|.|....|       ..|.|:: ....|.:...
Human    67 LRTSWP---RTRTTIIKEGMLTKQNNS----FQRSKRRYF-------KLRGRTL-YYAKTAKSII 116

  Fly   549 YKALSMTGSTVTYADGRTASASNS-------RRPI------RIVPDWTE--NAVQGEHYWKPTSA 598
            :..:.:|.::|  |:..|.:.:||       |:.|      :.:.||..  ..||...:::||..
Human   117 FDEVDLTDASV--AESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQY 179

  Fly   599 SGD-----------------LCCLNEECIK--SGQRMKCSACQLVAHHNCIPFVNEKSTLACK-P 643
            |.|                 .|.:..|.:.  :...:.|..|:..||..|.    .::|..|| .
Human   180 SMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCA----VRATNNCKWT 240

  Fly   644 TYRDVG--IRQYREQTTTHHHWVHRKLE-KGKC----KQCGKFFPMKQAVQSKLFGSKEIVALAC 701
            |...:|  |.:..:.....|.|:...|. ..||    |.||....::.              ..|
Human   241 TLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQD--------------WRC 291

  Fly   702 AWCHEIYHN--KEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGS 764
            .||..:.|.  ||:...      :|.||.....::||:.:..:.:.|.:|:|
Human   292 LWCKAMVHTSCKESLLT------KCPLGLCKVSVIPPTALNSIDSDGFWKAS------------- 337

  Fly   765 GGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKL 829
                                                    .|.....|::||:|.|||.|||.|.
Human   338 ----------------------------------------CPPSCTSPLLVFVNSKSGDNQGVKF 362

  Fly   830 LGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAV 894
            |.:|:.||||.|||||..|||.:||.:|:|....|:|.|||||:||||||.:|.:.  |.....:
Human   363 LRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLN--LHKQCQL 425

  Fly   895 GVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKV------------ 947
            |||||||||||||.||||.:.    ..|..:.:||.::..:...::|||.|..
Human   426 GVLPLGTGNDLARVLGWGSAC----DDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSS 486

  Fly   948 TPNDDVTDD-------------------------------------------------------- 956
            |..:|.::|
Human   487 TVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTE 551

  Fly   957 ----------------------------------------------------------------- 956
                                                                             
Human   552 SSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLV 616

  Fly   957 ---------------------------------HVDR---------------------------- 960
                                             |.::
Human   617 ASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDH 681

  Fly   961 --------------------------------SK------------------------------P 963
                                            ||                              |
Human   682 RVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYP 746

  Fly   964 NV----------------------PLN-------------VINNYFSFGVDAHIALEFHEAREAH 993
            ||                      |.|             |:||||..|:||.|:|:|:..|:.|
Human   747 NVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEH 811

  Fly   994 PERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGG 1058
            ||:..||.:|.|:||.:|.|:|:.|.|:||.|.|.|||||:    .:.......:..||||||.|
Human   812 PEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGR----PIPLPSLQGIAVLNIPSYAG 872

  Fly  1059 GTHPW-----NDSFGASKPSIDDGLMEVVGL-TTYQLP---MLQAGMHGTCICQCRKARIITKRT 1114
            ||:.|     :|:|.|  ||.||.::|||.: .:.|:.   :::...|....|:..|..|:....
Human   873 GTNFWGGTKEDDTFAA--PSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEG 935

  Fly  1115 IPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRG------DVQVNPLEK---MQLH---ILRV 1167
            :|:||||||....|..|.|...|:|..|::.:....      |.|...|.:   ..||   :...
Human   936 VPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEE 1000

  Fly  1168 TMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEESISYPKVSQDWCFIDSCT- 1231
            ...|.:|:.....:|.....::.|...:.:.:|.|..|..:...:.....|:.::..    :|:
Human  1001 EATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGL----NCSF 1061

  Fly  1232 ---AEHYFRIDRAQEHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQ 1293
               ..:.||..|::..|            :|..:.|.....|.:|:..:|.::...| .||..|.
Human  1062 VLEMVNNFRALRSETEL------------LLSGKMALQLDPPQKEQLGSALAEMDRQ-LRRLADT 1113

  Fly  1294 ---AQGRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSV 1355
               .|...||  ||:              |.:|:     :...::||...::....::   ..:.
Human  1114 PWLCQSAEPG--DEE--------------SVMLD-----LAKRSRSGKFRLVTKFKKE---KNNK 1154

  Fly  1356 NKNGQTAL-----------------HFA-CKYNHRDIVKYIIASATRRLINMADKELGQTALHIA 1402
            ||...::|                 |.: |:|  :||.       ||..|.      |...||:
Human  1155 NKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEY--KDIF-------TRHDIR------GSELLHL- 1203

  Fly  1403 AEQNRRDICVMLVAAGAHLDTLDSG 1427
               .|||:..:.|....|:..:..|
Human  1204 ---ERRDLKDLGVTKVGHMKRILCG 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_DGK_typeIV_rpt1	586..647	CDD:410352	17/80 (21%)
		C1_DGK_typeIV_rpt2	661..727	CDD:410405	15/72 (21%)
		DAGKc	814..942	CDD:214487	63/127 (50%)
		DAGKa	969..1123	CDD:214486	65/162 (40%)
		ANKYR	<1329..1452	CDD:440430	22/117 (19%)
		ANK repeat	1329..1356	CDD:293786	2/26 (8%)
		ANK repeat	1358..1391	CDD:293786	9/50 (18%)
		ANK repeat	1393..1425	CDD:293786	8/31 (26%)
DGKD	XP_054200226.1	PH_DGK_type2	79..175	CDD:270093	19/109 (17%)
		C1_DGKdelta_rpt1	164..248	CDD:410397	18/87 (21%)
		C1_DGKdelta_rpt2	255..315	CDD:410443	17/79 (22%)
		DAGKc	347..469	CDD:214487	63/127 (50%)
		DAGKa	787..944	CDD:214486	65/162 (40%)
		SAM_DGK-delta	1165..1229	CDD:188974	17/80 (21%)