DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and DGKD

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_011510330.1	Gene:	DGKD / 8527	HGNCID:	2851	Length:	1238	Species:	Homo sapiens

Alignment Length:	1390	Identity:	285/1390 - (20%)
Similarity:	448/1390 - (32%)	Gaps:	567/1390 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 VSHEEVDNSNTKSSVDTADSLDEASTMATC------GSPGAAG------GSGASSSHHNAFVVRD 483
            |:|:::.:.....:|  |.:|...|....|      |:||.||      .:||....      .|
Human    10 VTHQKLGSQGVHLAV--AGALQGHSCCCGCTVPLLPGNPGLAGVTSSTTWTGAEGQR------MD 66

  Fly   484 IYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDEQAR 548
            :....|   |.|...:........:|:    .|.|....|       ..|.|:: ....|.:...
Human    67 LRTSWP---RTRTTIIKEGMLTKQNNS----FQRSKRRYF-------KLRGRTL-YYAKTAKSII 116

  Fly   549 YKALSMTGSTVTYADGRTASASNS-------RRPI------RIVPDWTE--NAVQGEHYWKPTSA 598
            :..:.:|.::|  |:..|.:.:||       |:.|      :.:.||..  ..||...:::||..
Human   117 FDEVDLTDASV--AESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQY 179

  Fly   599 SGD-----------------LCCLNEECIK--SGQRMKCSACQLVAHHNCIPFVNEKSTLACK-P 643
            |.|                 .|.:..|.:.  :...:.|..|:..||..|.    .::|..|| .
Human   180 SMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCA----VRATNNCKWT 240

  Fly   644 TYRDVG--IRQYREQTTTHHHWVHRKLE-KGKC----KQCGKFFPMKQAVQSKLFGSKEIVALAC 701
            |...:|  |.:..:.....|.|:...|. ..||    |.||....::.              ..|
Human   241 TLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQD--------------WRC 291

  Fly   702 AWCHEIYHN--KEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGS 764
            .||..:.|.  ||:...      :|.||.....::||:.:..:.:.|.:|:|
Human   292 LWCKAMVHTSCKESLLT------KCPLGLCKVSVIPPTALNSIDSDGFWKAS------------- 337

  Fly   765 GGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKL 829
                                                    .|.....|::||:|.|||.|||.|.
Human   338 ----------------------------------------CPPSCTSPLLVFVNSKSGDNQGVKF 362

  Fly   830 LGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAV 894
            |.:|:.||||.|||||..|||.:||.:|:|....|:|.|||||:||||||.:|.:.  |.....:
Human   363 LRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLN--LHKQCQL 425

  Fly   895 GVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKV------------ 947
            |||||||||||||.||||.:.    ..|..:.:||.::..:...::|||.|..
Human   426 GVLPLGTGNDLARVLGWGSAC----DDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSS 486

  Fly   948 TPNDDVTDD-------------------------------------------------------- 956
            |..:|.::|
Human   487 TVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTE 551

  Fly   957 ----------------------------------------------------------------- 956

Human   552 SSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLV 616

  Fly   957 ---------------------------------HVDR---------------------------- 960
                                             |.::
Human   617 ASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDH 681

  Fly   961 --------------------------------SK------------------------------P 963
                                            ||                              |
Human   682 RVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYP 746

  Fly   964 NV----------------------PLN-------------VINNYFSFGVDAHIALEFHEAREAH 993
            ||                      |.|             |:||||..|:||.|:|:|:..|:.|
Human   747 NVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEH 811

  Fly   994 PERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGG 1058
            ||:..||.:|.|:||.:|.|:|:.|.|:||.|.|.|||||:    .:.......:..||||||.|
Human   812 PEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGR----PIPLPSLQGIAVLNIPSYAG 872

  Fly  1059 GTHPW-----NDSFGASKPSIDDGLMEVVGL-TTYQLP---MLQAGMHGTCICQCRKARIITKRT 1114
            ||:.|     :|:|.|  ||.||.::|||.: .:.|:.   :::...|....|:..|..|:....
Human   873 GTNFWGGTKEDDTFAA--PSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEG 935

  Fly  1115 IPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRG------DVQVNPLEK---MQLH---ILRV 1167
            :|:||||||....|..|.|...|:|..|::.:....      |.|...|.:   ..||   :...
Human   936 VPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEE 1000

  Fly  1168 TMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEESISYPKVSQDWCFIDSCT- 1231
            ...|.:|:.....:|.....::.|...:.:.:|.|..|..:...:.....|:.::..    :|:
Human  1001 EATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGL----NCSF 1061

  Fly  1232 ---AEHYFRIDRAQEHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQ 1293
               ..:.||..|::..|            :|..:.|.....|.:|:..:|.::...| .||..|.
Human  1062 VLEMVNNFRALRSETEL------------LLSGKMALQLDPPQKEQLGSALAEMDRQ-LRRLADT 1113

  Fly  1294 ---AQGRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSV 1355
               .|...||  ||:              |.:|:     :...::||...::....::   ..:.
Human  1114 PWLCQSAEPG--DEE--------------SVMLD-----LAKRSRSGKFRLVTKFKKE---KNNK 1154

  Fly  1356 NKNGQTAL-----------------HFA-CKYNHRDIVKYIIASATRRLINMADKELGQTALHIA 1402
            ||...::|                 |.: |:|  :||.       ||..|.      |...||:
Human  1155 NKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEY--KDIF-------TRHDIR------GSELLHL- 1203

  Fly  1403 AEQNRRDICVMLVAAGAHLDTLDSG 1427
               .|||:..:.|....|:..:..|
Human  1204 ---ERRDLKDLGVTKVGHMKRILCG 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	12/67 (18%)
		C1_1	661..725	CDD:278556	14/70 (20%)
		LCB5	813..1140	CDD:224513	149/626 (24%)
		DAGKc	814..942	CDD:214487	63/127 (50%)
		DAGKa	969..1123	CDD:214486	65/162 (40%)
		ANK	1329..1447	CDD:238125	22/117 (19%)
		ANK repeat	1329..1356	CDD:293786	2/26 (8%)
		Ank_2	1330..1425	CDD:289560	21/112 (19%)
		ANK repeat	1358..1391	CDD:293786	9/50 (18%)
		ANK repeat	1393..1425	CDD:293786	8/31 (26%)
		Ank_2	1399..>1459	CDD:289560	8/29 (28%)
DGKD	XP_011510330.1	PH	78..166	CDD:278594	17/101 (17%)
		PH_DGK_type2	79..175	CDD:270093	19/109 (17%)
		C1	188..237	CDD:237996	8/52 (15%)
		C1	260..310	CDD:237996	14/69 (20%)
		DAGKc	347..469	CDD:214487	63/127 (50%)
		DAGKa	787..944	CDD:214486	65/162 (40%)
		SAM_DGK-delta	1165..1229	CDD:188974	17/80 (21%)
		SAM	1166..1229	CDD:197735	17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155647
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840