DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and DGKZ

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_001099010.1	Gene:	DGKZ / 8525	HGNCID:	2857	Length:	1117	Species:	Homo sapiens

Alignment Length:	1240	Identity:	434/1240 - (35%)
Similarity:	600/1240 - (48%)	Gaps:	258/1240 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 GNMSQGSSIEESRARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHF-GNTLLPPQPTT---- 339
            |..:||||            ||.   ||:|..:.           :|.| .:.:|.|||||
Human    64 GVRAQGSS------------RRR---SSTVPPSC-----------NPRFIVDKVLTPQPTTVGAQ 102

  Fly   340 ----PCGIT--------------------FTLSP-TNGDYPSPPHLPLDPGSPPISPCSSNSGRL 379
                |..:|                    ..:.| |....|.||.     |:.|:.|       |
Human   103 LLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPR-----GAQPLLP-------L 155

  Fly   380 PALAPIISTPCSSADADDAGAAMGLPVRARRRSISRQEAIFVEPTGNSLENVSHEEVDNSNTKSS 444
            |......|:....|||....|..||....||.|..|       |:|      .|.
Human   156 PRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRR-------PSG------QHP---------- 197

  Fly   445 VDTADSLDEASTMATCGSPGAAGGSGASSSHHNAFVVRDIYLMVP----DLKRDRAASVDSCFSK 505
                             .||....||.::.           .|:|    .|.|.|..::
Human   198 -----------------GPGGRRASGTTAG-----------TMLPTRVRPLSRRRQVAL------ 228

  Fly   506 LSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRT--AS 568
                 :.:...|.|....|.                        ||::.:|.........|  |.
Human   229 -----RRKAAGPQAWSALLA------------------------KAITKSGLQHLAPPPPTPGAP 264

  Fly   569 ASNSRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEE-CI----KSGQRMKCSACQLVAHHN 628
            .|.|.|.||...||:|:|..|||.|..|:.|||.|.:.|: |:    ||..|.||:||::|.|..
Human   265 CSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTP 329

  Fly   629 CIPFVNEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGS 693
            ||..: ||....|||::|:.|.|..||.|...||||||:.:.|||:.|||.|..|..     |.|
Human   330 CIEQL-EKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFT-----FHS 388

  Fly   694 KEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKN 758
            |||||::|:||.:.||:|.:||...:|.|.|.||.:|.:::||:||::.....|   :::.|.|.
Human   389 KEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQN---TLKASKKK 450

  Fly   759 NAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGG 823
            ..||                 .|:::.:  ||.||.:. |.||::|.|||.:.|::||:||||||
Human   451 KRAS-----------------FKRKSSK--KGPEEGRW-RPFIIRPTPSPLMKPLLVFVNPKSGG 495

  Fly   824 NQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPL 888
            |||.|::..|...|||||||||:|||||..|:|:||..|||:|||||||||||:||.|||::  |
Human   496 NQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLR--L 558

  Fly   889 QPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDV 953
            :|.|.|.:|||||||||||.|.|||     ||||||:.|||..:.....|.:|||.:...||.:.
Human   559 KPPPPVAILPLGTGNDLARTLNWGG-----GYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 618

  Fly   954 -TDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLIL 1017
             .:|..:.:...:||:|.|||||.|.|||:.|||||:|||:||:||||.||||:|......|.::
Human   619 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLM 683

  Fly  1018 RQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPW-----NDSFGASKPSIDDG 1077
            ...::|::.:.:.|||.|.|.|::|.....|:|||||.|..||.||     :..|...:.  |||
Human   684 GSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRH--DDG 746

  Fly  1078 LMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALML 1142
            .:||:|.|...|..||.|.||..:.|||:..:.|.:.||:|||||.|::..|.|.|.|.|:|.|:
Human   747 YLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMV 811

  Fly  1143 SKRKHG-----RGDVQVNPLEKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEH 1202
            .|.|..     ..|.|..| |::::.:.||:|..||..|||||.|::.:..||.:.:....|||.
Human   812 QKAKRRSAAPLHSDQQPVP-EQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLEL 875

  Fly  1203 VRNMLNTKFEE-------SISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILD 1260
            .|..:....:|       |.:..|:|..|||:|:.||..::|||||||||:|:.:||.||:||||
Human   876 CRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILD 940

  Fly  1261 HE---AATMPQTPDQERSFAAFSQRQAQNERRQMDQAQGRGPGS-TDEDLQIGSKPIKVMKWKSP 1321
            .|   |:..|..|........                   .|.| |...||..:.|
Human   941 PELLGASARPDLPTPTSPLPT-------------------SPCSPTPRSLQGDAAP--------- 977

  Fly  1322 ILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVKYIIASATRRL 1386
               ...:.::.||:..|...|:.||..|..|...::..:|.||.|.....:|:|:|::..|...:
Human   978 ---PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEI 1039

  Fly  1387 INMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQ 1451
            :: |.:|.|:|.||.||...:|.||..:|.|||.|...|..|:||...|......|:|.|||::|
Human  1040 LD-AVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQ 1103

  Fly  1452 GTQPV 1456
            ..|.:
Human  1104 HYQMI 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	22/53 (42%)
		C1_1	661..725	CDD:278556	31/63 (49%)
		LCB5	813..1140	CDD:224513	167/332 (50%)
		DAGKc	814..942	CDD:214487	79/127 (62%)
		DAGKa	969..1123	CDD:214486	73/158 (46%)
		ANK	1329..1447	CDD:238125	39/117 (33%)
		ANK repeat	1329..1356	CDD:293786	8/26 (31%)
		Ank_2	1330..1425	CDD:289560	32/94 (34%)
		ANK repeat	1358..1391	CDD:293786	8/32 (25%)
		ANK repeat	1393..1425	CDD:293786	15/31 (48%)
		Ank_2	1399..>1459	CDD:289560	24/58 (41%)
DGKZ	NP_001099010.1	C1_1	361..420	CDD:278556	31/63 (49%)
		LCB5	482..805	CDD:224513	166/331 (50%)
		DAGKc	486..607	CDD:214487	79/127 (62%)
		DAGKa	635..792	CDD:214486	73/158 (46%)
		ANK	983..1099	CDD:238125	39/116 (34%)
		Ank_2	983..1077	CDD:289560	32/94 (34%)
		ANK repeat	983..1009	CDD:293786	8/25 (32%)
		ANK repeat	1011..1044	CDD:293786	9/33 (27%)
		ANK repeat	1046..1071	CDD:293786	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155658
Domainoid	1	1.000	175	1.000	Domainoid score	I3648
eggNOG	1	0.900	-	-		E1_KOG0782
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37831
Inparanoid	1	1.050	679	1.000	Inparanoid score	I717
Isobase	1	0.950	-	0	Normalized mean entropy	S4529
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143806at33208
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm40401
orthoMCL	1	0.900	-	-		OOG6_104636
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.710