Protein Alignment rdgA and Dgkz

DIOPT Version :10

• Sequence 1: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: NP_001416441.1
• Gene: Dgkz / 81821
• RGDID: 70929
• Length: 1121
• Species: Rattus norvegicus
• Alignment Length: 1396
• Identity: 450/1396 - (32%)
• Similarity: 630/1396 - (45%)
• Gaps: 337/1396 - (24%)

  Fly    97 ESQRASSSLLKQQSSSSASADERSSEAGFLQVPLAAHQQRSHSFDSATASAGSDDSGTFLEVPRR 161
            |.||.||.:     ........|.|.||.....||..::.|........|.|         |..|
  Rat    18 ERQRRSSGM-----GLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCFPSCG---------VGTR 68

  Fly   162 LKARRSSSTKTPPPCIHCHYLEEYERRMTAEQRYFIDHRELTALSYSNTSSEASEDEDEVEG-HN 225
            ..:||.||| .||.|               ..|:.:|  .:..|..:...::.......:.| .:
  Rat    69 GASRRRSST-APPTC---------------NPRFMVD--VVPTLQPATVGAQLLGAPLLLAGLMS 115

  Fly   226 AEEEEEGSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDPDDDAALEMDIRIGNMSQGSSIEE 290
            .:|||||:       :|..|.|...:|..|.|.. :...|                  |||   .
  Rat   116 MKEEEEGA-------QEGDETAEVSSDAKPGTRT-TPFSH------------------QGS---W 151

  Fly   291 SRARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTTPCGITFTLSPTNGDY- 354
            ....:||.:||    :||.                      |||..  ..||  .||...:|.|
  Rat   152 PLLPMPRCLRR----ASSY----------------------LLPAD--VECG--HTLWGLHGHYR 186

  Fly   355 ------PSPPHLPLDPGSPPISPCSSNSGRLPALAPIISTPCSSADADDAGAAMGLPVRARRRSI 413
                  ||..|..|...||.:|                            |||.|..:.||.|.:
  Rat   187 RLSQRWPSGQHPGLGGRSPRVS----------------------------GAAAGPMIPARVRPL 223

  Fly   414 SRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATCGSPGAAGGSGASSSHHNA 478
            ||:..:                                             |.....|.....|.
  Rat   224 SRRRQV---------------------------------------------ALRRKSAGPQPWNT 243

  Fly   479 FVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPT 543
            .:::.|                       :.:..:.|.|..                      ||
  Rat   244 LLMKAI-----------------------TKSGLQHLAPPP----------------------PT 263

  Fly   544 DEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEE 608
            .                     .|....|.|.||...||:|:|..|||.|..|:.|||.|.:.|:
  Rat   264 P---------------------GAPCGESERQIRSTVDWSESAAYGEHIWFETNVSGDFCYVGEQ 307

  Fly   609 -CI-----KSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRK 667
             |:     ||..|.||:||::|.|..||..: ||....|||::|:.|.|..||.|...||||||:
  Rat   308 YCVAKMLPKSAPRRKCAACKIVVHTPCIGQL-EKINFRCKPSFRESGSRNVREPTFVRHHWVHRR 371

  Fly   668 LEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPI 732
            .:.|||:.|||.|..|..     |.||||||::|:||.:.||:|.:||...:|.|.|.||.:|.:
  Rat   372 RQDGKCRHCGKGFQQKFT-----FHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAV 431

  Fly   733 IVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEP 797
            ::||:||::.....|   :::.|.|...||                 .|:::.:  ||.||.:.
  Rat   432 VIPPTWILRARRPQN---TLKASKKKKRAS-----------------FKRRSSK--KGPEEGRW- 473

  Fly   798 RAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPN 862
            |.||::|.|||.:.|::||:|||||||||.|::..|...|||||||||:||||:..|:|:||..|
  Rat   474 RPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHN 538

  Fly   863 LRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGK 927
            ||:|||||||||||:||.|||::  |:|.|.|.:|||||||||||.|.|||     ||||||:.|
  Rat   539 LRILACGGDGTVGWILSTLDQLR--LKPPPPVAILPLGTGNDLARTLNWGG-----GYTDEPVSK 596

  Fly   928 ILREIGMSQCVLMDRWRVKVTPNDDV-TDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEARE 991
            ||..:.....|.:|||.::..||.:. .::..|.:...:||:|.|||||.|.|||:.|||||:||
  Rat   597 ILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESRE 661

  Fly   992 AHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSY 1056
            |:||:||||.||||:|......|.::...::|::.:.:.|||.|.|.|::|.....::|||||.|
  Rat   662 ANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRY 726

  Fly  1057 GGGTHPW-----NDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIP 1116
            ..||.||     :..|...:.  |||.:||:|.|...|..||.|.||..:.|||:..:.|.:.||
  Rat   727 CAGTMPWGHPGEHHDFEPQRH--DDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIP 789

  Fly  1117 MQVDGEACRVKPSVIEIELLNKALMLSKRKHG-----RGDVQVNPLEKMQLHILRVTMQQYEQYH 1176
            :|||||.|::..|.|.|.|.|:|.|:.|.|..     ..|.|..| |::::.:.||:|..||..|
  Rat   790 VQVDGEPCKLAASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVP-EQLRIQVSRVSMHDYEALH 853

  Fly  1177 YDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEE--------SISYPKVSQDWCFIDSCTAE 1233
            ||||.|::.:..||.:.:....|||..|..:....:|        .:.:| :|..|||:|:.||.
  Rat   854 YDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHP-LSSKWCFLDATTAS 917

  Fly  1234 HYFRIDRAQEHLHYICDIAIDELYILDHE---AATMPQTPDQERSFAAFSQRQAQNERRQMDQAQ 1295
            .::|||||||||:|:.:||.||:||||.|   |:..|..|.......|              ...
  Rat   918 RFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPA--------------SPC 968

  Fly  1296 GRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSVNKNGQ 1360
            ...|||...|..:                ...:.::.||:..|...|:.||..|..|...:...:
  Rat   969 SPTPGSLQGDAAL----------------PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDHQSR 1017

  Fly  1361 TALHFACKYNHRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLD 1425
            |.||.|.....:::|:|::..|...::: |.:|.|:|.||.||...:|.||..:|.|||.|...|
  Rat  1018 TLLHHAVSTGSKEVVRYLLDHAPPEILD-AVEENGETCLHQAAALGQRTICHYIVEAGASLMKTD 1081

  Fly  1426 SGGNTPMMVAFNKNANEIATYLESKQGTQPV 1456
            ..|:||...|......|:|.|||::|..|.:
  Rat  1082 QQGDTPRQRAEKAQDTELAAYLENRQHYQMI 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_DGK_typeIV_rpt1	586..647	CDD:410352	28/66 (42%)
		C1_DGK_typeIV_rpt2	661..727	CDD:410405	32/65 (49%)
		DAGKc	814..942	CDD:214487	78/127 (61%)
		DAGKa	969..1123	CDD:214486	72/158 (46%)
		ANKYR	<1329..1452	CDD:440430	41/122 (34%)
		ANK repeat	1329..1356	CDD:293786	8/26 (31%)
		ANK repeat	1358..1391	CDD:293786	7/32 (22%)
		ANK repeat	1393..1425	CDD:293786	15/31 (48%)
Dgkz	NP_001416441.1	None