DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and Dgkz

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_006234656.1	Gene:	Dgkz / 81821	RGDID:	70929	Length:	1121	Species:	Rattus norvegicus

Alignment Length:	1396	Identity:	450/1396 - (32%)
Similarity:	630/1396 - (45%)	Gaps:	337/1396 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ESQRASSSLLKQQSSSSASADERSSEAGFLQVPLAAHQQRSHSFDSATASAGSDDSGTFLEVPRR 161
            |.||.||.:     ........|.|.||.....||..::.|........|.|         |..|
  Rat    18 ERQRRSSGM-----GLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCFPSCG---------VGTR 68

  Fly   162 LKARRSSSTKTPPPCIHCHYLEEYERRMTAEQRYFIDHRELTALSYSNTSSEASEDEDEVEG-HN 225
            ..:||.||| .||.|               ..|:.:|  .:..|..:...::.......:.| .:
  Rat    69 GASRRRSST-APPTC---------------NPRFMVD--VVPTLQPATVGAQLLGAPLLLAGLMS 115

  Fly   226 AEEEEEGSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDPDDDAALEMDIRIGNMSQGSSIEE 290
            .:|||||:       :|..|.|...:|..|.|.. :...|                  |||   .
  Rat   116 MKEEEEGA-------QEGDETAEVSSDAKPGTRT-TPFSH------------------QGS---W 151

  Fly   291 SRARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTTPCGITFTLSPTNGDY- 354
            ....:||.:||    :||.                      |||..  ..||  .||...:|.|
  Rat   152 PLLPMPRCLRR----ASSY----------------------LLPAD--VECG--HTLWGLHGHYR 186

  Fly   355 ------PSPPHLPLDPGSPPISPCSSNSGRLPALAPIISTPCSSADADDAGAAMGLPVRARRRSI 413
                  ||..|..|...||.:|                            |||.|..:.||.|.:
  Rat   187 RLSQRWPSGQHPGLGGRSPRVS----------------------------GAAAGPMIPARVRPL 223

  Fly   414 SRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATCGSPGAAGGSGASSSHHNA 478
            ||:..:                                             |.....|.....|.
  Rat   224 SRRRQV---------------------------------------------ALRRKSAGPQPWNT 243

  Fly   479 FVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPT 543
            .:::.|                       :.:..:.|.|..                      ||
  Rat   244 LLMKAI-----------------------TKSGLQHLAPPP----------------------PT 263

  Fly   544 DEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEE 608
            .                     .|....|.|.||...||:|:|..|||.|..|:.|||.|.:.|:
  Rat   264 P---------------------GAPCGESERQIRSTVDWSESAAYGEHIWFETNVSGDFCYVGEQ 307

  Fly   609 -CI-----KSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRK 667
             |:     ||..|.||:||::|.|..||..: ||....|||::|:.|.|..||.|...||||||:
  Rat   308 YCVAKMLPKSAPRRKCAACKIVVHTPCIGQL-EKINFRCKPSFRESGSRNVREPTFVRHHWVHRR 371

  Fly   668 LEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPI 732
            .:.|||:.|||.|..|..     |.||||||::|:||.:.||:|.:||...:|.|.|.||.:|.:
  Rat   372 RQDGKCRHCGKGFQQKFT-----FHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAV 431

  Fly   733 IVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEP 797
            ::||:||::.....|   :::.|.|...||                 .|:::.:  ||.||.:.
  Rat   432 VIPPTWILRARRPQN---TLKASKKKKRAS-----------------FKRRSSK--KGPEEGRW- 473

  Fly   798 RAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPN 862
            |.||::|.|||.:.|::||:|||||||||.|::..|...|||||||||:||||:..|:|:||..|
  Rat   474 RPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHN 538

  Fly   863 LRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGK 927
            ||:|||||||||||:||.|||::  |:|.|.|.:|||||||||||.|.|||     ||||||:.|
  Rat   539 LRILACGGDGTVGWILSTLDQLR--LKPPPPVAILPLGTGNDLARTLNWGG-----GYTDEPVSK 596

  Fly   928 ILREIGMSQCVLMDRWRVKVTPNDDV-TDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEARE 991
            ||..:.....|.:|||.::..||.:. .::..|.:...:||:|.|||||.|.|||:.|||||:||
  Rat   597 ILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESRE 661

  Fly   992 AHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSY 1056
            |:||:||||.||||:|......|.::...::|::.:.:.|||.|.|.|::|.....::|||||.|
  Rat   662 ANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRY 726

  Fly  1057 GGGTHPW-----NDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIP 1116
            ..||.||     :..|...:.  |||.:||:|.|...|..||.|.||..:.|||:..:.|.:.||
  Rat   727 CAGTMPWGHPGEHHDFEPQRH--DDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIP 789

  Fly  1117 MQVDGEACRVKPSVIEIELLNKALMLSKRKHG-----RGDVQVNPLEKMQLHILRVTMQQYEQYH 1176
            :|||||.|::..|.|.|.|.|:|.|:.|.|..     ..|.|..| |::::.:.||:|..||..|
  Rat   790 VQVDGEPCKLAASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVP-EQLRIQVSRVSMHDYEALH 853

  Fly  1177 YDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEE--------SISYPKVSQDWCFIDSCTAE 1233
            ||||.|::.:..||.:.:....|||..|..:....:|        .:.:| :|..|||:|:.||.
  Rat   854 YDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHP-LSSKWCFLDATTAS 917

  Fly  1234 HYFRIDRAQEHLHYICDIAIDELYILDHE---AATMPQTPDQERSFAAFSQRQAQNERRQMDQAQ 1295
            .::|||||||||:|:.:||.||:||||.|   |:..|..|.......|              ...
  Rat   918 RFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPA--------------SPC 968

  Fly  1296 GRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQSVNKNGQ 1360
            ...|||...|..:                ...:.::.||:..|...|:.||..|..|...:...:
  Rat   969 SPTPGSLQGDAAL----------------PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDHQSR 1017

  Fly  1361 TALHFACKYNHRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLD 1425
            |.||.|.....:::|:|::..|...::: |.:|.|:|.||.||...:|.||..:|.|||.|...|
  Rat  1018 TLLHHAVSTGSKEVVRYLLDHAPPEILD-AVEENGETCLHQAAALGQRTICHYIVEAGASLMKTD 1081

  Fly  1426 SGGNTPMMVAFNKNANEIATYLESKQGTQPV 1456
            ..|:||...|......|:|.|||::|..|.:
  Rat  1082 QQGDTPRQRAEKAQDTELAAYLENRQHYQMI 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	22/54 (41%)
		C1_1	661..725	CDD:278556	31/63 (49%)
		LCB5	813..1140	CDD:224513	165/332 (50%)
		DAGKc	814..942	CDD:214487	78/127 (61%)
		DAGKa	969..1123	CDD:214486	72/158 (46%)
		ANK	1329..1447	CDD:238125	38/117 (32%)
		ANK repeat	1329..1356	CDD:293786	8/26 (31%)
		Ank_2	1330..1425	CDD:289560	31/94 (33%)
		ANK repeat	1358..1391	CDD:293786	7/32 (22%)
		ANK repeat	1393..1425	CDD:293786	15/31 (48%)
		Ank_2	1399..>1459	CDD:289560	24/58 (41%)
Dgkz	XP_006234656.1	C1	365..424	CDD:294036	31/63 (49%)
		LCB5	486..809	CDD:224513	164/331 (50%)
		DAGKc	490..611	CDD:214487	78/127 (61%)
		DAGKa	639..796	CDD:214486	72/158 (46%)
		ANK	987..1103	CDD:238125	38/116 (33%)
		Ank_2	987..1081	CDD:289560	31/94 (33%)
		ANK repeat	987..1013	CDD:293786	8/25 (32%)
		ANK repeat	1015..1048	CDD:293786	8/33 (24%)
		ANK repeat	1050..1075	CDD:293786	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349561
Domainoid	1	1.000	175	1.000	Domainoid score	I3546
eggNOG	1	0.900	-	-		E1_KOG0782
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37831
Inparanoid	1	1.050	707	1.000	Inparanoid score	I624
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143806at33208
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm44537
orthoMCL	1	0.900	-	-		OOG6_104636
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.800