DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgA and dgkaa

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_005162385.1	Gene:	dgkaa / 724010	ZFINID:	ZDB-GENE-060616-305	Length:	766	Species:	Danio rerio

Alignment Length:	917	Identity:	247/917 - (26%)
Similarity:	361/917 - (39%)	Gaps:	252/917 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 DIRIGNMSQGSSIEESRARL-----------PRQMRRHTIGS-SSVTSASEDEG--LEGSDNGSP 326
            |.|:.....|..|:|...||           |..:.:....| .:..||..||.  :|..|.
Zfish    41 DGRLAKYRHGECIDEEGFRLFLKTYLEVEDFPSDLCQRLFRSFQNSESAKSDENSWIEDEDE--- 102

  Fly   327 HFGNTLLPPQPTTPCGITFTLSPTNGDYPSPPHLPLDPGSPPISPCSSNSGRLPALAPIISTPCS 391
                         .|.|.:||..|
Zfish   103 -------------DCSILYTLETT----------------------------------------- 113

  Fly   392 SADADDAGAAMGLPVRARRRSISRQEA--IFVEPTGNSLENVS--HEEVDNSNTKSSVDTADSLD 452
                 |....||  .|.:::.::|:::  :|       |::||  ...::....:..:|.|..|.
Zfish   114 -----DKETTMG--NRKQKQGVARRKSGEVF-------LKDVSCYFSLLEEGQPRDKLDFAFKLY 164

  Fly   453 EASTMATCGSPGAAGGSG-----------ASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKL 506
            :..            |:|           |...|...::..|:..:.|.|| |...::|   :..
Zfish   165 DRD------------GNGFLDSSEVDRIIAQMMHAADYLGWDVSELRPVLK-DMMTAID---ADS 213

  Fly   507 SSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASN 571
            |....:||.   .||....||                       .|.:.|..:|..||:..
Zfish   214 SGTVSSEEW---VDGGLKNVP-----------------------LLVLLGLKMTQKDGQHL---- 248

  Fly   572 SRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEECIKSGQRMKCSACQLVAHHNCIPFVNEK 636
                      |     :.:|:.||...:   .|.|.......|.:.|:.|:...|..|.    .|
Zfish   249 ----------W-----RMKHFNKPVYCN---VCQNMLLGLRKQGLCCTCCRYTVHGRCA----NK 291

  Fly   637 STLACKPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALAC 701
            :...|..||    :...:|.....|.||....:.|||..|          |.|:.....:....|
Zfish   292 NPAPCTRTY----VMSKKETGIAVHDWVSGNCDSGKCDGC----------QKKIKSLHGLTGKRC 342

  Fly   702 AWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGG 766
            .|||.:.|  :||..|...  .|..|.:...|:|| |.: .|.         |..:.|.....|
Zfish   343 VWCHTMRH--DACATQEPF--TCDCGPFKVHILPP-WAI-YPV---------VKERPNCIKNGG- 391

  Fly   767 GGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLG 831
                              .......|....|...:::..|.|:..|::||:||||||.||.::|.
Zfish   392 ------------------SFPDDDSELNTTPDGQVLRISPIPDTRPLLVFVNPKSGGKQGERVLR 438

  Fly   832 KFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGV 896
            |||:|||||||::|:.|||..||..||..||.|:|.|||||||||:|..:|:...|::  |.|.|
Zfish   439 KFQYLLNPRQVYNLSNGGPGPGLSFFRDVPNYRILVCGGDGTVGWILDAIDKANLPVR--PPVAV 501

  Fly   897 LPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRS 961
            |||||||||||.|.|||     ||....:|:||::|.:|:...||||.::||     .:|..:|.
Zfish   502 LPLGTGNDLARCLRWGG-----GYDGMDLGRILKDIEVSEEGPMDRWSIQVT-----LEDSQERG 556

  Fly   962 KPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQW 1026
            .| ||..:||||||.||||.||..||..||.||::||||::||::|.:....:.|....:.|.:.
Zfish   557 DP-VPYEIINNYFSIGVDASIAHRFHTMREKHPQKFNSRMKNKLWYFEFATSETISASCKKLKEC 620

  Fly  1027 VTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDS-------------------FGASKP 1072
            :|:||.|...  .|.......:..|||||..||::.|.::                   ...|..
Zfish   621 LTIECCGTQL--DLSSLSLEGIAILNIPSMHGGSNLWGEAKKSDRMDQKLPEVIVDPEILKVSPQ 683

  Fly  1073 SIDDGLMEVVGLT-TYQLPMLQAGMHGTC-ICQCRKARIITKRTIPMQVDGEACRVKPSVIEIEL 1135
            .:.|..:|||||. ..::..:..|:.... :.:..:..|.||:.:|||:|||.....|..|.|..
Zfish   684 DMSDKRLEVVGLEGAMEMGQIYTGLKSAVRLAKTSQITIRTKKPLPMQIDGEPWMQPPCTIHITH 748

  Fly  1136 LNKALML 1142
            .|:|.||
Zfish   749 KNQASML 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	11/48 (23%)
		C1_1	661..725	CDD:278556	17/63 (27%)
		LCB5	813..1140	CDD:224513	142/347 (41%)
		DAGKc	814..942	CDD:214487	71/127 (56%)
		DAGKa	969..1123	CDD:214486	56/174 (32%)
		ANK	1329..1447	CDD:238125
		ANK repeat	1329..1356	CDD:293786
		Ank_2	1330..1425	CDD:289560
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
		Ank_2	1399..>1459	CDD:289560
dgkaa	XP_005162385.1	DAG_kinase_N	12..151	CDD:291199	29/180 (16%)
		EFh	156..225	CDD:238008	16/87 (18%)
		EF-hand_7	157..221	CDD:290234	14/79 (18%)
		C1	247..296	CDD:237996	12/74 (16%)
		C1	312..364	CDD:294036	18/65 (28%)
		LCB5	421..744	CDD:224513	139/337 (41%)
		DAGKc	421..542	CDD:214487	71/127 (56%)
		DAGKa	563..736	CDD:214486	56/174 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840