DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgA and LOC567728

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_021334575.1	Gene:	LOC567728 / 567728	-ID:	-	Length:	893	Species:	Danio rerio

Alignment Length:	1027	Identity:	277/1027 - (26%)
Similarity:	401/1027 - (39%)	Gaps:	262/1027 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 YSNTSSEASEDE-DEVEG------HNAEEEEEGSAAIEDAEEETTEAATEEADEDPR-------T 257
            ||..||:..:|. :|..|      :|.|::::......|.|.......|...::.|.       |
Zfish    18 YSEYSSKKLKDVLEEFHGNGVLSKYNPEQKQDVLNQPIDYEGFQLFMTTYLENDIPEELCKHLFT 82

  Fly   258 EVESEH--DHDPDDDAALEMDIRIGNMSQGSSIEESRARLPRQMRRHTIGSSSVTSASEDEGLEG 320
            ..:|::  :..||...|....:...::..|.||:...|..|..    .:...|:.||......|.
Zfish    83 SFKSKNGGEGSPDTSRAGAGILEPKSIDAGISIQTEVACAPIT----GMNGKSILSAMSRHTAES 143

  Fly   321 SDNGSPHFGNTLLPPQPTTPCG--ITFTLSPTNGDYPSPPHLPLDPGSPPISPC-SSNSGRLPAL 382
            |...:|..|.|      |:||.  .:...|.|.|..|..||  ..||:.|..|. ||:|....||
Zfish   144 SAGITPGSGAT------TSPCSSRSSSQRSGTGGHTPRGPH--RSPGTQPKPPTGSSSSSNALAL 200

  Fly   383 APIISTPCSSADADDAGAAMGLPVRARRRSISRQ------EAIFV-------------------- 421
            :...::|..|.:.:.:.....|     |||.|.|      :.:|:
Zfish   201 SKTSNSPRLSPERNQSENRTSL-----RRSPSPQKGSPSPQVVFLKDIVCYLSLLERGTPEDKLE 260

  Fly   422 ------EPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATCGSPGAAGGSGASSSHHNAFV 480
                  :..||.|  :...|:|.. ....|..|:.|:..||.
Zfish   261 FMFRLYDTDGNGL--LDSSELDRI-INQMVHVAEYLEWDSTE----------------------- 299

  Fly   481 VRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDE 545
                  :.|.||.                 ..||:....||
Zfish   300 ------LRPILKE-----------------MMEEIDYDRDG------------------------ 317

  Fly   546 QARYKALSMTGSTVTYAD----GRTASASNSRRPIRIVPDWTENAVQ-GEHYWKPTSASGDLCCL 605
                        |||..:    |.|..      |:.::.....|..: |:|.||....:....|.
Zfish   318 ------------TVTLEEWIRGGMTTI------PLLVLLGMETNVQEDGQHIWKLKHFNKPAYCN 364

  Fly   606 NEECIKSGQRMK---CSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRK 667
            ....:..|.|.:   |:.|:...|..|:    .|....|..||    .:..|......|.|:...
Zfish   365 YCHTMLLGVRKQGLCCALCKYTVHERCV----SKDIAPCISTY----AKSRRHTNAMQHVWMEGN 421

  Fly   668 LEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPI 732
             ...||.:|.:.....|.          :..|.|.||....|||  |.:..|  .||..|.....
Zfish   422 -SSAKCDKCHRSIKCYQG----------LTGLHCVWCQITLHNK--CASNMK--PECDGGPLRDH 471

  Fly   733 IVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEK--K 795
            .:.||:|..:           |.::::|..            .|.|:|...|.....|:..|  .
Zfish   472 TLLPSYICPV-----------VLDRHSAVK------------RGEGESSPSTSPEDTGQCFKFTG 513

  Fly   796 EPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKA 860
            :.:|..:.|:|...  |::|.:||||||.||.::|.|||:|||||||:.|.:|||..||:.||..
Zfish   514 DGQALQITPLPGTH--PLLVLVNPKSGGRQGERVLRKFQYLLNPRQVYSLERGGPMAGLNFFRDV 576

  Fly   861 PNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPI 925
            |:.|||||||||:|||:|..:|:..  ....|.|.:|||||||||||.|.|||     ||....:
Zfish   577 PDFRVLACGGDGSVGWILDCIDKAS--FARHPPVAILPLGTGNDLARCLRWGG-----GYEGGSL 634

  Fly   926 GKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAR 990
            .|.||:|..|..||:|||.:.:.|     ||..::..| ||.:::|||||.||||.||..||..|
Zfish   635 VKFLRDIEHSTEVLLDRWNIDIVP-----DDKEEKGDP-VPYSIVNNYFSIGVDASIAHRFHLMR 693

  Fly   991 EAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPS 1055
            |.|||:||||::||::|.:.|..:.|....:.|::.:.:||||  ....|.......:..|||||
Zfish   694 EKHPEKFNSRMKNKLWYFEFGTTETISATCKKLNETIEVECDG--IILDLSSTSLEGIAVLNIPS 756

  Fly  1056 YGGGTHPWNDS--------FGASKP-------------------SIDDGLMEVVGLT-TYQLPML 1092
            ..||::.|.::        .....|                   .:.|.|:|||||. ..::..:
Zfish   757 MHGGSNLWGETKKRRNYNRMSKKVPERMTGSTVTDAKELKFCVQDLSDQLLEVVGLEGAIEMGQI 821

  Fly  1093 QAGMH--GTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALML 1142
            ..|:.  |..:.||....|.|.|.:|||:|||.....|..|.|...|:..||
Zfish   822 YTGLKSAGRRLAQCSNVTIRTSRLLPMQIDGEPWMQPPCTIRITHKNQVPML 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	11/51 (22%)
		C1_1	661..725	CDD:278556	16/63 (25%)
		LCB5	813..1140	CDD:224513	144/356 (40%)
		DAGKc	814..942	CDD:214487	69/127 (54%)
		DAGKa	969..1123	CDD:214486	61/183 (33%)
		ANK	1329..1447	CDD:238125
		ANK repeat	1329..1356	CDD:293786
		Ank_2	1330..1425	CDD:289560
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
		Ank_2	1399..>1459	CDD:289560
LOC567728	XP_021334575.1	DAG_kinase_N	4..93	CDD:316983	15/74 (20%)
		Herpes_BLLF1	<106..>237	CDD:330317	39/147 (27%)
		EFh	258..327	CDD:238008	20/153 (13%)
		C1	350..399	CDD:237996	11/52 (21%)
		C1_1	415..466	CDD:278556	17/65 (26%)
		DAGKc	530..651	CDD:214487	69/127 (54%)
		DAGKa	672..854	CDD:214486	61/183 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590846
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840