DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and dgkza

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_021333603.1	Gene:	dgkza / 553380	ZFINID:	ZDB-GENE-111104-3	Length:	1294	Species:	Danio rerio

Alignment Length:	1516	Identity:	486/1516 - (32%)
Similarity:	684/1516 - (45%)	Gaps:	415/1516 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 KQQSSSS--ASADERSSEAGFLQVPLAAHQQRSHSFDSATASAGSDDSGTFLEVPRRLKARRSS- 168
            :::||.|  ||...|.|.||.....| ||::||    ||....||...|..|........|:||
Zfish    19 RRRSSVSLPASKARRRSSAGLPSAGL-AHRRRS----SAQLQIGSIQPGLVLHRRGHFTRRKSSG 78

  Fly   169 --STKTPPPCIHCHYLEEYERRMTAEQRYFIDHRELTALSYSNTSSEASEDEDEVEGHNAEEEEE 231
              :..||...|        .||..|:.|..  |.:|...|....|.....::.|.|..:|||
Zfish    79 GTACLTPRFAI--------RRRQAAKHRSI--HAQLLGPSLLLASVVQMSEDHEPEDKSAEE--- 130

  Fly   232 GSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDPDDDAALEMDIRIGNMSQGSSIEES----- 291
             .:::.|     |:.:.:|.:       ::..|.:.:.|..|..      ::||..:.||
Zfish   131 -YSSLSD-----TDCSQDEHE-------QTGMDFETESDKCLTW------LAQGLLVGESIQPRP 176

  Fly   292 RARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQPTTPCGITFTLSPTNGDYPS 356
            ..|.||.:||:                      |.|                   |.|....|.|
Zfish   177 LIRAPRCLRRN----------------------SSH-------------------LLPAEAVYRS 200

  Fly   357 PPHLPLDPGSPPISPCSSNSGRLPALAPIISTPCSSADADDAGAAMGLPVRARRRSISRQEAIFV 421
            |                                          |:.||..|.||.|
Zfish   201 P------------------------------------------ASYGLYGRYRRTS--------- 214

  Fly   422 EPTGNSLENVSHEEVDN-----SNTKSSVDTADSLDEASTMATCGSPGAAGGSGASSSHHNAFVV 481
                         :|.|     :..:||:                   ||.||.|
Zfish   215 -------------QVHNMGGLWAGKRSSL-------------------AARGSVA---------- 237

  Fly   482 RDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATR---SRSVDIVLPT 543
              :|...|           .|:..||       :..:..|.:.. |.|:...   |:::
Zfish   238 --LYRTSP-----------PCWPDLS-------VSHTLQGTYYN-PQIDTWSGFLSKAI------ 275

  Fly   544 DEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEE 608
             .::..:.||...|....|.|.|      .|.||...||:|:||.|||.|..|:.|||.|.:.|:
Zfish   276 -AKSGLQHLSCQPSAAVLAKGET------DREIRNTVDWSESAVYGEHIWFETNVSGDFCYVGEQ 333

  Fly   609 -CI-----KSGQRMKCSACQLVAHHNCIPFVNE-----------------------KSTLACKPT 644
             |.     ||..|.||:||::|.|..||..:.:                       :....|||:
Zfish   334 HCYAKSLQKSVARKKCAACKIVVHSICIEQLEKLLDWNAPPQGEGLDEMPLKEPSFRINFRCKPS 398

  Fly   645 YRDVGIRQYREQT----------------------TTH----------HHWVHRKLEKGKCKQCG 677
            :|:.|.|..||||                      |.|          ||||||:.::|||||||
Zfish   399 FRESGSRNIREQTWRRRAFRGRCALEQMRGAAAKCTAHTSNTQPAIVRHHWVHRRRQEGKCKQCG 463

  Fly   678 KFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKL 742
            |.|..|.|     |.||||||::|:||.:.||||..||...:|.|.|.||.:|.:||||:||:::
Zfish   464 KGFQQKFA-----FHSKEIVAISCSWCKQAYHNKVTCFMLQQIEEPCSLGAHAAVIVPPTWIIRV 523

  Fly   743 PTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQ-RRQKGKEEKKEPR--AFIVKP 804
            ...   :||::.|                       |.||:|. :|:..|:..:|.|  .|||:|
Zfish   524 RRP---QSSLKSS-----------------------KKKKRTSFKRKSSKKGAEEARWKPFIVRP 562

  Fly   805 IPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACG 869
            |||..:.|::||:|||||||||.|::..|...|||||||||:||||:.||:|:||..|||:||||
Zfish   563 IPSQLMKPLLVFVNPKSGGNQGAKIIQTFLWYLNPRQVFDLSQGGPQEGLEMYRKVHNLRILACG 627

  Fly   870 GDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGM 934
            |||||||:||.|||:|  |.|:|||.||||||||||||.|.|||     ||||||:.|||..:..
Zfish   628 GDGTVGWILSALDQLQ--LNPSPAVAVLPLGTGNDLARTLNWGG-----GYTDEPLSKILSHVED 685

  Fly   935 SQCVLMDRWRVKVTPNDDVTDDHVDRS-KPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFN 998
            ...|.:|||.:.|.||.:...:..|.. ...:||:|.|||||.|.|||:.|||||:|||:||:||
Zfish   686 GNIVQLDRWNLVVKPNPEAGPEERDEQVTDKLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFN 750

  Fly   999 SRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPW 1063
            ||.||||:|......|.::...::|::.:.:.|||.|.|.|::|.....::|||||.|..||.||
Zfish   751 SRFRNKMFYAGTAFSDFLMGSSKDLAKHIKVVCDGTDLTSKVQDLKLQCLVFLNIPRYCAGTMPW 815

  Fly  1064 NDSFGASKPS---------IDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIPMQV 1119
            .:      ||         .|||.:||:|.|...|..||.|.||..:.|||:..:.|.::|||||
Zfish   816 GN------PSEHHDFEPQRHDDGCIEVIGFTMTSLATLQVGGHGERLNQCREVTLTTFKSIPMQV 874

  Fly  1120 DGEACRVKPSVIEIELLNKALMLSKRKHGR-----GDVQVNPLEKMQLHILRVTMQQYEQYHYDK 1179
            |||.|::.||||.|.|.|:|.|:.|.|...     .|.|....|::::.:.|::|..||..||||
Zfish   875 DGEPCKLAPSVIHISLRNQANMVQKTKRRTSIPLLNDSQQPFPERLRIRVSRISMHDYEALHYDK 939

  Fly  1180 EMLRKLANKLGQIEIESQCDLE----HVRNM------LNTKFE------------ESISYPKVSQ 1222
            |.|::.:..||.|.:....|||    |:..:      .|...:            :::|..::|.
Zfish   940 EKLKEASIPLGLIVVPGDSDLETCRAHIERLQEDFVSCNPSLQRLVLQEGDGSKSKALSSQRLSP 1004

  Fly  1223 DWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILDHE------AATMPQTPD---------- 1271
            .|||:||.||:.::|||||||||:|:.:|:.|||::||.|      .:|.|..||
Zfish  1005 KWCFLDSTTADRFYRIDRAQEHLNYVTEISQDELFVLDPELVVTETVSTSPGMPDLVDSGEVQSD 1069

  Fly  1272 -QERSFAAFSQ--------RQAQNERRQMDQAQGRGPGSTDEDLQIGSKPIKVMKW--------- 1318
             .:.:|.:.|.        |.|:.:|:::.............|....:||......
Zfish  1070 PHKFAFPSSSSSPPNTPGPRVAELQRKRVSSDSSVAEALAHSDSLRSAKPALCRAGGVHRSNTTA 1134

  Fly  1319 ----------KSPILEQTS---DAILLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYN 1370
                      ||.:....|   |:::...:..|...|:.||::|..|...:..|:|.||:|.:..
Zfish  1135 ADFKPTSRFEKSAVNNANSVSVDSLIECVKKKDHQKLKELHKKGADLCVQDPAGRTLLHYAVEVG 1199

  Fly  1371 HRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVA 1435
            .::||||||.:|...::::.:||.|:|.||.||....|.||..||.|||.|...|..|:||...|
Zfish  1200 SKEIVKYIIDNAPTDILDVTEKENGETVLHKAASLCHRTICHYLVEAGASLMKTDLQGDTPKHRA 1264

  Fly  1436 FNKNANEIATYLESKQGTQPV 1456
            ......|:|.|||::|..|.:
Zfish  1265 EKAKDAELAAYLENRQHYQMI 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	20/77 (26%)
		C1_1	661..725	CDD:278556	35/63 (56%)
		LCB5	813..1140	CDD:224513	174/336 (52%)
		DAGKc	814..942	CDD:214487	82/127 (65%)
		DAGKa	969..1123	CDD:214486	74/162 (46%)
		ANK	1329..1447	CDD:238125	42/117 (36%)
		ANK repeat	1329..1356	CDD:293786	6/26 (23%)
		Ank_2	1330..1425	CDD:289560	35/94 (37%)
		ANK repeat	1358..1391	CDD:293786	12/32 (38%)
		ANK repeat	1393..1425	CDD:293786	16/31 (52%)
		Ank_2	1399..>1459	CDD:289560	25/58 (43%)
dgkza	XP_021333603.1	C1_1	447..506	CDD:278556	35/63 (56%)
		DAGKc	572..693	CDD:214487	82/127 (65%)
		DAGKa	721..878	CDD:214486	74/162 (46%)
		ANK	1159..1276	CDD:238125	42/116 (36%)
		ANK repeat	1159..1185	CDD:293786	6/25 (24%)
		ANK repeat	1187..1217	CDD:293786	12/29 (41%)
		ANK repeat	1223..1248	CDD:293786	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590841
Domainoid	1	1.000	180	1.000	Domainoid score	I3453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37831
Inparanoid	1	1.050	706	1.000	Inparanoid score	I642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143806at33208
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm24981
orthoMCL	1	0.900	-	-		OOG6_104636
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900