DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and Dgkk

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_038956233.1	Gene:	Dgkk / 367745	RGDID:	1561510	Length:	1385	Species:	Rattus norvegicus

Alignment Length:	1438	Identity:	315/1438 - (21%)
Similarity:	468/1438 - (32%)	Gaps:	550/1438 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 SSEASEDEDEVEGHNAEE---EEEGSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDPDDDAA 272
            |....|.:.|.:..:|.|   |.:...|.|...|..:|.| .|.|.:|.:|...|.|.:||.:.|
  Rat   126 SERVPEPDPEPDSESAPEPDPEPDSEPAPEPDPEPDSEPA-PEPDPEPDSEPAPEPDPEPDSEPA 189

  Fly   273 LEMDIRIGNMSQGSSIEESRARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLPPQP 337
            .|.|           .|....|:|.                                     |.|
  Rat   190 PEPD-----------PEPDSERVPE-------------------------------------PDP 206

  Fly   338 TTPCGITFTLSPTNGDYPSPPHLPLDPGSPPISPCSSNSGRLPALAP-----IISTPCSSADAD- 396
                      .|.:...|.|...|....:|...| ..:|.|:|..||     :.|.|......|
  Rat   207 ----------EPDSERAPEPDPEPDSEPAPEPDP-EPDSERVPEPAPDPTLELASEPTREPTPDL 260

  Fly   397 DAGAAMGLPVRARRRSISRQEAIFVEPTGNS----------LENVSHEEVDNSN----------- 440
            |.|.|:       ..::.|......|||..|          |:.|..|:...::
  Rat   261 DTGLAL-------EPAMERAPESCPEPTPESCPKMSPALHLLQVVPGEKSGRTSPVLLPLPSPKP 318

  Fly   441 --TKSSVDTADSLDEASTMATCGS-------PGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRA 496
              |.|.:...  |.|...:..|.|       .....|.....:||.:|.    :....||.:...
  Rat   319 PVTWSRIKKI--LKEGPLLKNCNSFKRWKLRYCLIQGQKLHFAHHPSFA----HFETIDLSQVVL 377

  Fly   497 ASVDSCFSKLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTY 561
            |. .||             :....|..:..|:      |.|.:|.|: .|...:.:::. .||..
  Rat   378 AE-SSC-------------RNLCHGFCVITPH------RKVSLVAPS-RQDMEEWINII-KTVQQ 420

  Fly   562 ADGRTASASNSRRPIRIVPDWTENAVQGEHYW----KPTSASGDLCCLNEECIKSGQRMKCSACQ 622
            .:.|...|:.: .|..|          |.|||    .|.:...::|..|...: |...:.|..|:
  Rat   421 GEIRQIPAAEN-NPFLI----------GMHYWYSSPNPRTQFCNVCRENIPAL-SRDAIICEVCK 473

  Fly   623 LVAHHNCIPFVNEKSTLACK---PTYRDVGIRQYREQTTTHHHWVHRKL-EKGKC----KQCGKF 679
            :.:|..|....|:.    ||   .:..|..:....|..|..|.||...: ...:|    :.||.:
  Rat   474 VKSHKVCALRANKD----CKWNTLSITDDLLLPADEIQTMPHQWVEGNIPANSQCTVCHESCGSY 534

  Fly   680 FPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPT 744
            ..::.              ..|.||....|.  ||  |.:..:||..|:...:||||:
  Rat   535 HRLQD--------------FRCLWCGSTVHG--AC--QKRFSKECSFGSCRSLIVPPT------- 574

  Fly   745 KGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPE 809
                           |.|...|.|                                  :.:.|.|
  Rat   575 ---------------ALSDPRGDG----------------------------------QLVVSSE 590

  Fly   810 V----------IPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLR 864
            .          .|:::|||.|||.:||...|.||:..|||.|||||.:|||:.|:.||:.....|
  Rat   591 FWNLDWPLTCSCPLLIFINSKSGDHQGIIFLRKFKQYLNPSQVFDLAKGGPEAGIAMFKNFARFR 655

  Fly   865 VLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKIL 929
            ||.|||||:|.||||.:|..  .|.....:.::||||||||||.||||.   |......|: :||
  Rat   656 VLVCGGDGSVSWVLSTIDAY--GLHDRCQMAIIPLGTGNDLARVLGWGA---FWSKGKSPL-EIL 714

  Fly   930 REIGMSQCVLMDRWRVKV--TPN------------------------------------------ 950
            ..:..:...::|||.|.:  ||.
  Rat   715 SRVEQAHVRILDRWSVMIRETPKPVPLLKGQVGMDIPRFEAAAIKNVESATTELNKILKAKYPTE 779

  Fly   951 ------------DDVTDDHV--------------------------------------------- 958
                        .|..||.|
  Rat   780 MVIATRFLCSAVQDFIDDIVKAWHQIKQNTTAVESVILKSDLMYDKLSVLLDLLAEDAVAASAER 844

  Fly   959 ------DRSKP------------------------------------------------------ 963
                  .||||
  Rat   845 TATAYGSRSKPDGKAFVPELDHIAKAKMELAERAQKLQQSLKLILFQVEQVLDDESRQSLSVKNF 909

  Fly   964 -----------------------------------------NVPLN---------------VINN 972
                                                     |:.|.               |:||
  Rat   910 ASSLFLGDGDDDSDDYDQSPRHRSRCDTLSSIPSLRSEDLDNLDLEHLHVTPETIRFKERCVMNN 974

  Fly   973 YFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFT 1037
            ||..|:||.|:|||:..||.|||::||||:||::||.:|.|:|:.|.||.|.:.:.|||||:
  Rat   975 YFGIGLDAKISLEFNARREEHPEQYNSRLKNKIWYGLLGSKELLQRSYRKLEERIHLECDGE--- 1036

  Fly  1038 GKLRDAGCHAVLFLNIPSYGGGTHPWNDSFGASK---PSIDDGLMEVVGL-TTYQLPMLQ-AGMH 1097
             .:.......::.|||.||.||.:.|..:...::   |:||||.:|||.: .:.|:.|.: ..:|
  Rat  1037 -AVSLPNLQGIVVLNITSYAGGVNFWGSNTATTEYEAPAIDDGKLEVVAIFGSVQMAMSRIINLH 1100

  Fly  1098 GTCICQCRKARIIT---KRTIPMQVDGEACRVKPSVIEIELLNKALMLSK------------RKH 1147
            ...|.|||:. |||   :..||:||||||...||.:|:|:..|.|.||.:            .||
  Rat  1101 HHRIAQCREV-IITIDGEGGIPVQVDGEAWIQKPGLIKIKYKNTAQMLMRDRDFENSMKTWESKH 1164

  Fly  1148 GRGDVQVNPLEKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFE 1212
              .::|..|...:.....:.::...| |...:.:.|:..|.:.::     .||..|...::.
  Rat  1165 --TEIQAVPAPHLDFQESQDSLSDGE-YAQMQHLARRAENLISRL-----TDLSKVHQHVSV--- 1218

  Fly  1213 ESISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILD--HEAA--------TMP 1267
                         .:||..|.               ..|..|..|..|  :||.        |:.
  Rat  1219 -------------LMDSVNAS---------------ATILNDVFYSQDSGNEAGAASCIPIETLS 1255

  Fly  1268 QTPDQERSFA---AFSQRQAQNERRQMDQAQGRGPGSTDED-LQIGSKPIKVMKWKSPIL---EQ 1325
            :|...:.:|:   .:...:|..:...:..|:.|....|..| :.:..:.|..:.|.|.|.   ||
  Rat  1256 RTDAVDVTFSLKGLYDDTKAFLDENLLRDAKDRAMLETALDAMNMELRRILAIGWLSQIFYPEEQ 1320

  Fly  1326 TSDAILLA 1333
            .||...|:
  Rat  1321 ASDTYSLS 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	12/52 (23%)
		C1_1	661..725	CDD:278556	14/68 (21%)
		LCB5	813..1140	CDD:224513	150/551 (27%)
		DAGKc	814..942	CDD:214487	58/127 (46%)
		DAGKa	969..1123	CDD:214486	69/161 (43%)
		ANK	1329..1447	CDD:238125	1/5 (20%)
		ANK repeat	1329..1356	CDD:293786	1/5 (20%)
		Ank_2	1330..1425	CDD:289560	1/4 (25%)
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
		Ank_2	1399..>1459	CDD:289560
Dgkk	XP_038956233.1	Trypan_PARP	<79..148	CDD:368653	5/21 (24%)
		Trypan_PARP	<198..292	CDD:368653	26/148 (18%)
		PH_DGK_type2	329..423	CDD:270093	22/119 (18%)
		C1_DGK_typeII_rpt1	437..494	CDD:410350	15/61 (25%)
		C1_DGK_typeII_rpt2	511..564	CDD:410402	15/70 (21%)
		DAGKc	605..727	CDD:214487	58/127 (46%)
		DAGKa	971..1128	CDD:214486	69/161 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840