DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and Dgki

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_017177113.1	Gene:	Dgki / 320127	MGIID:	2443430	Length:	1112	Species:	Mus musculus

Alignment Length:	1161	Identity:	439/1161 - (37%)
Similarity:	609/1161 - (52%)	Gaps:	167/1161 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 DADDAGAAMGLPVRARR---RSISRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEAS 455
            ||...|..: ||:.|.|   |:.:...|:  .|||          :.:..|.:|...|.::....
Mouse     2 DAAGRGCHL-LPLPAARGPARAPAASSAL--SPTG----------LCSGTTSASFAAAGAVAMNP 53

  Fly   456 TMATCGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSAD 520
            :.:.....||.|||.:|.|...:..:            ......|...:..::.|..||  |:|.
Mouse    54 SSSAGEERGATGGSSSSGSGAGSCCL------------GAEGGADPRGAGAAAAAALEE--PAAA 104

  Fly   521 GCFLTVPNINATRSRSVDIVLPTDEQARY-KALSMTG---STVTYADGRTASASNSRRPIRIVPD 581
            |   ......|...:..|:..  .:|..| ||:|.||   ....:..|...:...::.| |...|
Mouse   105 G---QKEKEEALEEKLRDLTF--RKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEP-RATLD 163

  Fly   582 WTENAVQGEHYWKPTSASGDLCCLNEE-C----IKSGQRMKCSACQLVAHHNCIPFVNEKSTLAC 641
            |:||||.|||.|..|:.|||||.|.|| |    .||..|.||:.|::|.|..||..: ||....|
Mouse   164 WSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQL-EKINFRC 227

  Fly   642 KPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHE 706
            |||:|:.|.|..|| ....||||||:.::||||||||.|..|.:     |.||||||::|:||.:
Mouse   228 KPTFREGGSRSPRE-NFVRHHWVHRRRQEGKCKQCGKGFQQKFS-----FHSKEIVAISCSWCKQ 286

  Fly   707 IYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGG----G 767
            .:|||..||....|.|.|.||.:|.:||||:||:|:             .|....|..|.    |
Mouse   287 AFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKV-------------KKPQVISIPGDELELG 338

  Fly   768 GAGGGAGGGG-------------------------GKSKKQTQRRQK----GKEEKKEPRAFIVK 803
            .||.|.|..|                         .:.||:|..::|    |.|::.:.|.|::|
Mouse   339 WAGDGPGWAGDWSPSENLGFFHFYWEGWQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIK 403

  Fly   804 PIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLAC 868
            ||.||.:.|::||:|||||||||.|:|..|...|||||||||:|.|||..|:|:||.||||:|||
Mouse   404 PISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILAC 468

  Fly   869 GGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIG 933
            ||||||||:||:||::|  |.|.|.||||||||||||||.|.|||     ||||||:.|||.::.
Mouse   469 GGDGTVGWILSILDELQ--LSPQPPVGVLPLGTGNDLARTLNWGG-----GYTDEPVSKILCQVE 526

  Fly   934 MSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFN 998
            ....|.:|||.:.|..|.|:..:.::.....:||||.|||||.|.|||:.|||||:|||:||:||
Mouse   527 DGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFN 591

  Fly   999 SRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPW 1063
            ||.||||:|......|.:.|..|:||:.|.:.|||.|.|.|::|.....::|||||.|..||.||
Mouse   592 SRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPW 656

  Fly  1064 ---NDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIPMQVDGEACR 1125
               .|.........|||.:||:|.|...|..||.|.||..:.|||:..::|.::||||||||.||
Mouse   657 GNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCR 721

  Fly  1126 VKPSVIEIELLNKALMLSKRKHGRGDVQVNPL-------------------------EKMQLHIL 1165
            :.|::|.|.|.|:|.|:.|.|.......:|.:                         :::::.:.
Mouse   722 LAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVN 786

  Fly  1166 RVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLN---------------------- 1208
            ::::|.||..||||:.||:.:..||.:.:...||||..|..::
Mouse   787 KISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQE 851

  Fly  1209 TKFEESISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILD------HEAATMP 1267
            |.|..::|..::|..|||:|:.:|:.::||||:|||||::.:|:.||::|||      .:|.|.|
Mouse   852 TSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPP 916

  Fly  1268 QTPD--QERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAI 1330
            ..||  .|::............:|.:..:....|...|.||:..|.. :|:  :||:..: ..||
Mouse   917 GMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHS-RVL--QSPVSSE-DHAI 977

  Fly  1331 LLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVKYIIASATRRLINMADKELG 1395
            |.|..:|||..|...::.|.||........:.||:|.|..:.||||||:......|::|||.|.|
Mouse   978 LQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETG 1042

  Fly  1396 QTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQ 1451
            :||||.||.|..|.:|.:||.|||.|...||.|.||...|......::|.||||:|
Mouse  1043 ETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQ 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	24/53 (45%)
		C1_1	661..725	CDD:278556	33/63 (52%)
		LCB5	813..1140	CDD:224513	176/329 (53%)
		DAGKc	814..942	CDD:214487	82/127 (65%)
		DAGKa	969..1123	CDD:214486	77/156 (49%)
		ANK	1329..1447	CDD:238125	49/117 (42%)
		ANK repeat	1329..1356	CDD:293786	11/26 (42%)
		Ank_2	1330..1425	CDD:289560	41/94 (44%)
		ANK repeat	1358..1391	CDD:293786	12/32 (38%)
		ANK repeat	1393..1425	CDD:293786	17/31 (55%)
		Ank_2	1399..>1459	CDD:289560	25/53 (47%)
Dgki	XP_017177113.1	C1_1	246..303	CDD:365894	32/61 (52%)
		DAGKc	414..535	CDD:214487	82/127 (65%)
		DAGKa	562..719	CDD:214486	77/156 (49%)
		ANKYR	910..1109	CDD:223738	69/193 (36%)
		ANK repeat	972..1003	CDD:293786	11/31 (35%)
		Ank_2	977..1072	CDD:372319	41/94 (44%)
		ANK repeat	1007..1038	CDD:293786	12/30 (40%)
		ANK repeat	1040..1072	CDD:293786	17/31 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846094
Domainoid	1	1.000	176	1.000	Domainoid score	I3590
eggNOG	1	0.900	-	-		E1_KOG0782
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	701	1.000	Inparanoid score	I668
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143806at33208
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm42473
orthoMCL	1	0.900	-	-		OOG6_104636
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2485
SonicParanoid	1	1.000	-	-		X1934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790