Protein Alignment rdgA and Dgki

DIOPT Version :10

• Sequence 1: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_017177113.1
• Gene: Dgki / 320127
• MGIID: 2443430
• Length: 1112
• Species: Mus musculus
• Alignment Length: 1161
• Identity: 439/1161 - (37%)
• Similarity: 609/1161 - (52%)
• Gaps: 167/1161 - (14%)

  Fly   394 DADDAGAAMGLPVRARR---RSISRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEAS 455
            ||...|..: ||:.|.|   |:.:...|:  .|||          :.:..|.:|...|.::....
Mouse     2 DAAGRGCHL-LPLPAARGPARAPAASSAL--SPTG----------LCSGTTSASFAAAGAVAMNP 53

  Fly   456 TMATCGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSAD 520
            :.:.....||.|||.:|.|...:..:            ......|...:..::.|..||  |:|.
Mouse    54 SSSAGEERGATGGSSSSGSGAGSCCL------------GAEGGADPRGAGAAAAAALEE--PAAA 104

  Fly   521 GCFLTVPNINATRSRSVDIVLPTDEQARY-KALSMTG---STVTYADGRTASASNSRRPIRIVPD 581
            |   ......|...:..|:..  .:|..| ||:|.||   ....:..|...:...::.| |...|
Mouse   105 G---QKEKEEALEEKLRDLTF--RKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEP-RATLD 163

  Fly   582 WTENAVQGEHYWKPTSASGDLCCLNEE-C----IKSGQRMKCSACQLVAHHNCIPFVNEKSTLAC 641
            |:||||.|||.|..|:.|||||.|.|| |    .||..|.||:.|::|.|..||..: ||....|
Mouse   164 WSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQL-EKINFRC 227

  Fly   642 KPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHE 706
            |||:|:.|.|..|| ....||||||:.::||||||||.|..|.:     |.||||||::|:||.:
Mouse   228 KPTFREGGSRSPRE-NFVRHHWVHRRRQEGKCKQCGKGFQQKFS-----FHSKEIVAISCSWCKQ 286

  Fly   707 IYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGG----G 767
            .:|||..||....|.|.|.||.:|.:||||:||:|:             .|....|..|.    |
Mouse   287 AFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKV-------------KKPQVISIPGDELELG 338

  Fly   768 GAGGGAGGGG-------------------------GKSKKQTQRRQK----GKEEKKEPRAFIVK 803
            .||.|.|..|                         .:.||:|..::|    |.|::.:.|.|::|
Mouse   339 WAGDGPGWAGDWSPSENLGFFHFYWEGWQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIK 403

  Fly   804 PIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLAC 868
            ||.||.:.|::||:|||||||||.|:|..|...|||||||||:|.|||..|:|:||.||||:|||
Mouse   404 PISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILAC 468

  Fly   869 GGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIG 933
            ||||||||:||:||::|  |.|.|.||||||||||||||.|.|||     ||||||:.|||.::.
Mouse   469 GGDGTVGWILSILDELQ--LSPQPPVGVLPLGTGNDLARTLNWGG-----GYTDEPVSKILCQVE 526

  Fly   934 MSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFN 998
            ....|.:|||.:.|..|.|:..:.::.....:||||.|||||.|.|||:.|||||:|||:||:||
Mouse   527 DGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFN 591

  Fly   999 SRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPW 1063
            ||.||||:|......|.:.|..|:||:.|.:.|||.|.|.|::|.....::|||||.|..||.||
Mouse   592 SRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPW 656

  Fly  1064 ---NDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCICQCRKARIITKRTIPMQVDGEACR 1125
               .|.........|||.:||:|.|...|..||.|.||..:.|||:..::|.::||||||||.||
Mouse   657 GNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCR 721

  Fly  1126 VKPSVIEIELLNKALMLSKRKHGRGDVQVNPL-------------------------EKMQLHIL 1165
            :.|::|.|.|.|:|.|:.|.|.......:|.:                         :::::.:.
Mouse   722 LAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVN 786

  Fly  1166 RVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLN---------------------- 1208
            ::::|.||..||||:.||:.:..||.:.:...||||..|..::
Mouse   787 KISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQE 851

  Fly  1209 TKFEESISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILD------HEAATMP 1267
            |.|..::|..::|..|||:|:.:|:.::||||:|||||::.:|:.||::|||      .:|.|.|
Mouse   852 TSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPP 916

  Fly  1268 QTPD--QERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAI 1330
            ..||  .|::............:|.:..:....|...|.||:..|.. :|:  :||:..: ..||
Mouse   917 GMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHS-RVL--QSPVSSE-DHAI 977

  Fly  1331 LLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVKYIIASATRRLINMADKELG 1395
            |.|..:|||..|...::.|.||........:.||:|.|..:.||||||:......|::|||.|.|
Mouse   978 LQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETG 1042

  Fly  1396 QTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQ 1451
            :||||.||.|..|.:|.:||.|||.|...||.|.||...|......::|.||||:|
Mouse  1043 ETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQ 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_DGK_typeIV_rpt1	586..647	CDD:410352	32/65 (49%)
		C1_DGK_typeIV_rpt2	661..727	CDD:410405	34/65 (52%)
		DAGKc	814..942	CDD:214487	82/127 (65%)
		DAGKa	969..1123	CDD:214486	77/156 (49%)
		ANKYR	<1329..1452	CDD:440430	54/123 (44%)
		ANK repeat	1329..1356	CDD:293786	11/26 (42%)
		ANK repeat	1358..1391	CDD:293786	12/32 (38%)
		ANK repeat	1393..1425	CDD:293786	17/31 (55%)
Dgki	XP_017177113.1	C1_DGKiota_rpt1	163..235	CDD:410400	37/72 (51%)
		C1_DGKiota_rpt2	244..318	CDD:410446	41/78 (53%)
		DAGKc	414..535	CDD:214487	82/127 (65%)
		DAGKa	562..719	CDD:214486	77/156 (49%)
		ANK repeat	972..1003	CDD:293786	11/31 (35%)
		ANKYR	<994..1111	CDD:440430	46/105 (44%)
		ANK repeat	1007..1038	CDD:293786	12/30 (40%)
		ANK repeat	1040..1072	CDD:293786	17/31 (55%)