DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgA and Dgkg

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_037258.1	Gene:	Dgkg / 25666	RGDID:	2499	Length:	788	Species:	Rattus norvegicus

Alignment Length:	828	Identity:	239/828 - (28%)
Similarity:	341/828 - (41%)	Gaps:	222/828 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 EPTGNSLENVSHEEVDNS---------NTKSS-VDTADSLDEASTMATCGSPGAAGGSGASSSHH 476
            |...:|..|||....:::         :|:|. :.|....:|....|..|.|.|.    ||||..
  Rat    93 EGASSSEPNVSDSNAESTAKADAACAPDTESKPIKTQVPSEELEAAAPWGEPNAP----ASSSDA 153

  Fly   477 NAFVVRDI--YLMVPDLKRDR-------------------AASVDSCFSKLSSNAKTEELQPS-- 518
            ....::|:  ||.:.:..|.:                   .|.:|...|::...|:..|..|:
  Rat   154 PIVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENELLDQAELDQIVSQMLHVAQYLEWDPTEL 218

  Fly   519 ------------------------ADGCFLTVPNINATRSRSVDIVLPTDEQARYKALSMTGSTV 559
                                    ..|...|:|.:         ::|..|:.|
  Rat   219 RPILKEMLQGMDYNKDGFVSLEEWVSGGMTTIPLL---------VLLGMDDSA------------ 262

  Fly   560 TYADGRTASASNSRRPIRIVPDWTENAVQGEHYWKPTSASGDLCCLNEECIKSGQRMKCSACQLV 624
            :..|||.|              ||.     :|:.|||..  :.|.:....::. |.:.|..|:..
  Rat   263 SKGDGRHA--------------WTL-----KHFKKPTYC--NFCHIMLMGVRK-QGLCCIYCKYA 305

  Fly   625 AHHNCIPFVNEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSK 689
            .|..|:    ..|...|..||.    :..|......|.||... ...||.:|.|.....|:|
  Rat   306 VHQRCV----SNSIPGCVKTYS----KAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCYQSV--- 358

  Fly   690 LFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRV 754
                   .|..|.||...:|.|      .::...|..|.....|:.|:.|..:
  Rat   359 -------TARHCVWCRMTFHRK------CELSTACDGGELKDHILLPTSIYPV------------ 398

  Fly   755 SNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEK----KEPRAFIVKPIPSPEVIPVIV 815
                                         |:.||.||.:.    |.......|.||||...|::|
  Rat   399 -----------------------------TRDRQAGKSDSGAAAKGELVMQYKIIPSPGTHPLLV 434

  Fly   816 FINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSV 880
            .:||||||.||.::|.||.:||||:|||:|.:|||..||:.|:..|:.|||||||||||||:|..
  Rat   435 LVNPKSGGRQGERILQKFHYLLNPKQVFNLDKGGPTPGLNFFQDTPDFRVLACGGDGTVGWILDC 499

  Fly   881 LDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRV 945
            :|:..  ....|.|.||||||||||||.|.|||     ||....:.|||:||..|..|::|||.:
  Rat   500 IDKAN--FTKHPPVAVLPLGTGNDLARCLRWGG-----GYEGGSLTKILKEIEQSPLVMLDRWYL 557

  Fly   946 KVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQM 1010
            :|.|.::|      .:...||.|::|||||.||||.||..||..||.|||:||||::||::|.:.
  Rat   558 EVMPREEV------ENGDQVPYNIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEF 616

  Fly  1011 GGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDS------FGA 1069
            |..:......:.|...:.|||||.:.  .|.:.....:..|||||..|||:.|.::      ...
  Rat   617 GTSETFAATCKKLHDHIELECDGVEV--DLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRE 679

  Fly  1070 SKPSI-------------DDGLMEVVGLT-TYQLPMLQAGMH--GTCICQCRKARIITKRTIPMQ 1118
            |:.|:             .|.|:|||||. ..::..:..|:.  |..:.||....|.||:.:|||
  Rat   680 SRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTKKLLPMQ 744

  Fly  1119 VDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNPLEKMQLHILR 1166
            ||||.....|.:|:|...|:|.|:           :.|.:|.....||
  Rat   745 VDGEPWMQPPCMIKITHKNQAPMM-----------MGPPQKSSFFSLR 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	11/48 (23%)
		C1_1	661..725	CDD:278556	15/63 (24%)
		LCB5	813..1140	CDD:224513	147/348 (42%)
		DAGKc	814..942	CDD:214487	69/127 (54%)
		DAGKa	969..1123	CDD:214486	64/175 (37%)
		ANK	1329..1447	CDD:238125
		ANK repeat	1329..1356	CDD:293786
		Ank_2	1330..1425	CDD:289560
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
		Ank_2	1399..>1459	CDD:289560
Dgkg	NP_037258.1	DAG_kinase_N	5..172	CDD:291199	20/82 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..150		14/60 (23%)
		EFh	176..245	CDD:238008	6/68 (9%)
		EF-hand_7	177..241	CDD:290234	6/63 (10%)
		C1	269..318	CDD:237996	14/74 (19%)
		C1	333..380	CDD:197519	15/63 (24%)
		LCB5	433..759	CDD:224513	145/340 (43%)
		DAGKc	433..554	CDD:214487	69/127 (54%)
		DAGKa	575..749	CDD:214486	64/175 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..788		4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349564
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840