DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and Dgkd

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_006529534.1	Gene:	Dgkd / 227333	MGIID:	2138334	Length:	1227	Species:	Mus musculus

Alignment Length:	1299	Identity:	268/1299 - (20%)
Similarity:	424/1299 - (32%)	Gaps:	537/1299 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 KLSSNAKTEELQPSADGCFLTVPNINATRSRSVDIVL--------PTDEQARYKALSMTGSTVTY 561
            |:|::.:..:.....:| .||..|.:..||:.....|        .|.:...:..:.:|.::|
Mouse    42 KVSTSGQIRQKTILKEG-MLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASV-- 103

  Fly   562 ADGRTASASNS-------RRPI------RIVPDWTE--NAVQGEHYWKPTSASGD---------- 601
            |:..|.:.:||       |:.|      :.:.||..  ..||.:.:::||..|.|
Mouse   104 AESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNKEHFEPTQYSMDHFSGMHNWYA 168

  Fly   602 -------LCCLNEECIK--SGQRMKCSACQLVAHHNCIPFVNEKSTLACK-PTYRDVG--IRQYR 654
                   .|.:..|.:.  :...:.|..|:..||..|.    .::|..|| .|...:|  |.:..
Mouse   169 CSHARPTYCNVCREVLSGVTSHGLSCEVCKFKAHKRCA----VRATSNCKWTTLASIGKDIIEDE 229

  Fly   655 EQTTTHHHWVHRKLE-KGKC----KQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEAC 714
            :.....|.|:...|. ..||    |.||....::.              ..|.||..:.|.  :|
Mouse   230 DGIAMPHQWLEGNLPVSAKCIVCDKTCGSVLRLQD--------------WRCLWCKAMVHT--SC 278

  Fly   715 FNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGK 779
              :..:..:|.||.....::||:.:..:.:.|.:|::
Mouse   279 --KESLVMKCPLGLCKVSVIPPTALNSIDSDGFWKAT---------------------------- 313

  Fly   780 SKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFD 844
                                     .|.....|::||:|.|||.|||.|.|.:|:.||||.||||
Mouse   314 -------------------------CPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFD 353

  Fly   845 LTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARAL 909
            |..|||.:||.:|:|....|:|.|||||:||||||.:|.:.  |.....:|||||||||||||.|
Mouse   354 LMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLN--LHKQCQLGVLPLGTGNDLARVL 416

  Fly   910 GWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKV------------TPNDDVTDD------ 956
            |||.:.    ..|..:.:||.::..:...::|||.|..            |..:|.::|
Mouse   417 GWGSAC----DDDTQLPQILAKLERASTKMLDRWSVMAYETKLPRQASSSTVTEDFSEDSEVQQI 477

  Fly   957 ---------HVDR---------------------------------------------------- 960
                     |:.:
Mouse   478 LFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSQESEVMAKKCSVL 542

  Fly   961 -------------------------------------------------------SKPNV----- 965
                                                                   |:|.:
Mouse   543 KEKLDSLLKTLDDESQASSSLSNPPPTIAEEAEDGDGSGNICSSTGDHLVGSACPSRPQIFRPRE 607

  Fly   966 ----------------------------------------------------------------- 965

Mouse   608 QLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQQGFVLGLSESEKKDLKTDNRVCTSSVHSESC 672

  Fly   966 ----------------------------------------------------------------- 965

Mouse   673 VIAKGRSQRKASRAPCEKLVSKGLSLGSSASLPPGTGSRDSLPALNTKILYPSVRAGMSGSLPGG 737

  Fly   966 -----------PLN-------------VINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMY 1006
                       |.|             |:||||..|:||.|:|:|:..|:.|||:..||.:|.|:
Mouse   738 SVISRLLINADPFNAEPENLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMW 802

  Fly  1007 YGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPW-----NDS 1066
            ||.:|.|:|:.|.||||.|.|.|||||:    .:.......:..||||||.|||:.|     :|:
Mouse   803 YGVLGTKELLHRTYRNLEQKVLLECDGR----PIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDT 863

  Fly  1067 FGASKPSIDDGLMEVVGL-TTYQLP---MLQAGMHGTCICQCRKARIITKRTIPMQVDGEACRVK 1127
            |.|  ||.||.::|||.: .:.|:.   :::...|....|:..|..|:....:|:||||||....
Mouse   864 FAA--PSFDDKILEVVAVFGSMQMAVSRVIKLQHHRIAQCRTVKISILGDEGVPVQVDGEAWIQP 926

  Fly  1128 PSVIEIELLNKALMLSKRK---------HGRGDVQVNPLEKMQLH--IL----RVTMQQYEQ--- 1174
            |..|.|...|:|..|::.:         ..:...:::......||  ||    ...|.|:.|
Mouse   927 PGYIRIVHKNRAQTLTRDRAFENTLKSWEDKQKCELSRPPSFSLHPEILSEEEATQMDQFGQAAG 991

  Fly  1175 --YHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEESISYPKVSQDWCFIDSCTAEHYFR 1237
              .|    .:|::|.....:|.|    |.|..|..:...|.....|:.::..    :|:.
Mouse   992 GLIH----SIREIAQSHRAMEQE----LAHAVNASSKAMERVYGKPRTAEGL----NCSF----- 1039

  Fly  1238 IDRAQEHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQ---AQGRGP 1299
               ..|.::.|..:..:...:|..:.|.....|.:||..||..:.. |..|:..|.   .|...|
Mouse  1040 ---VLEMVNNIRALRSETELLLAGKMALQLDPPQKERLGAALIEMD-QQLRKLTDTPWLCQPLEP 1100

  Fly  1300 GSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNML-RALHEQGYSLQSVNKNGQTAL 1363
            |. :|.||           ::.:|:.|.     .::||...:: :...|:....:.|:.|....:
Mouse  1101 GE-EESLQ-----------QNVMLDLTK-----RSRSGKFRLVTKFKKEKNNKNKEVHSNLGGPV 1148

  Fly  1364 HF--------------ACKYNHRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVM 1413
            |.              .|:|  :||.       ||..|.      |...||:    .|||:.|:
Mouse  1149 HLWGTEEVAAWLEHLSLCEY--KDIF-------TRHDIR------GSELLHL----ERRDLKVL 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	12/67 (18%)
		C1_1	661..725	CDD:278556	13/68 (19%)
		LCB5	813..1140	CDD:224513	147/628 (23%)
		DAGKc	814..942	CDD:214487	63/127 (50%)
		DAGKa	969..1123	CDD:214486	66/162 (41%)
		ANK	1329..1447	CDD:238125	20/100 (20%)
		ANK repeat	1329..1356	CDD:293786	3/27 (11%)
		Ank_2	1330..1425	CDD:289560	20/99 (20%)
		ANK repeat	1358..1391	CDD:293786	9/46 (20%)
		ANK repeat	1393..1425	CDD:293786	7/21 (33%)
		Ank_2	1399..>1459	CDD:289560	6/15 (40%)
Dgkd	XP_006529534.1	PH_DGK_type2	55..151	CDD:270093	20/98 (20%)
		C1	164..213	CDD:237996	8/52 (15%)
		C1	236..286	CDD:237996	13/67 (19%)
		DAGKc	323..445	CDD:214487	63/127 (50%)
		DAGKa	765..922	CDD:214486	66/162 (41%)
		SAM_superfamily	1147..>1193	CDD:387673	14/64 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846085
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840