DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and DGKH

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_821077.1	Gene:	DGKH / 160851	HGNCID:	2854	Length:	1220	Species:	Homo sapiens

Alignment Length:	1407	Identity:	304/1407 - (21%)
Similarity:	451/1407 - (32%)	Gaps:	623/1407 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 MATCGS----PGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKL-----SSNAKT 512
            ||..|.    ||||||:.|.:                      .|:|.|..:..     ||:::.
Human     1 MAGAGGQHHPPGAAGGAAAGA----------------------GAAVTSAAASAGPGEDSSDSEA 43

  Fly   513 EELQP-------SADGCFLTVPNINATRSRSVDIVLPTDEQARYKA--LSMTGSTVTY------- 561
            |:..|       |..|...|..:|     :...::..|....|:|.  ..:.|.|:.|
Human    44 EQEGPQKLIRKVSTSGQIRTKTSI-----KEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSL 103

  Fly   562 ------------ADGRTASASNS-------RRPI------RIVPDWTEN--AVQ----------- 588
                        |:..|.:|:||       ||.:      :.:.||..:  :||
Human   104 IFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFN 168

  Fly   589 -----GEHYWKPTS-ASGDLCCLNEECIK--SGQRMKCSACQLVAHHNCIPFVNEKSTLACK-PT 644
                 |.|.|...| |....|.:..|.:.  :...:.|..|:..||..|.    .::|..|| .|
Human   169 VEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCA----VRATNNCKWTT 229

  Fly   645 YRDVG--IRQYREQTTTHHHWVHRKLE-KGKC----KQCGKFFPMKQAVQSKLFGSKEIVALACA 702
            ...:|  |.:..:.....|.|:...|. ..||    |.||....::.              ..|.
Human   230 LASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQD--------------WKCL 280

  Fly   703 WCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGG 767
            ||..:.|.  ||  :......|.||.....|:||..:....:.|..:::.
Human   281 WCKTMVHT--AC--KDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRATF--------------- 326

  Fly   768 GAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGK 832
                                           :|.|.|:        :||:|.|||.|||.|.|.:
Human   327 -------------------------------SFCVSPL--------LVFVNSKSGDNQGVKFLRR 352

  Fly   833 FQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVL 897
            |:.||||.|||||..|||.:||.:|:|..|.|:|.|||||:||||||.:|::.  |.....:|||
Human   353 FKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLN--LNKQCQLGVL 415

  Fly   898 PLGTGNDLARALGWGGSIFFQGYTDE-PIGKILREIGMSQCVLMDRWRV-----KVTP------- 949
            ||||||||||.||||||     |.|: .:.:||.::..:...::|||.:     |:.|
Human   416 PLGTGNDLARVLGWGGS-----YDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPG 475

  Fly   950 ----------------------------------------------------------------- 949

Human   476 PPEASEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA 540

  Fly   950 -----------------------------------------------------------NDDVT- 954
                                                                       .||||
Human   541 DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTK 605

  Fly   955 ----------------------------------------------------------------D 955
                                                                            |
Human   606 PSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTETDESKEEAKD 670

  Fly   956 D----------------------H----------VDRSKPNVP-LN------------------- 968
            |                      |          |..||.|:| ||
Human   671 DGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRIICPGLRAGLAASIAGS 735

  Fly   969 ----------------------------------VINNYFSFGVDAHIALEFHEAREAHPERFNS 999
                                              |:||||..|:||.|:|||:..||.|||:..|
Human   736 SIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRS 800

  Fly  1000 RLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPW- 1063
            |.:|.|:||.:|.::|:.|.|:||.|.|.||||||    .:.......:..||||||.|||:.|
Human   801 RTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQ----YIPLPSLQGIAVLNIPSYAGGTNFWG 861

  Fly  1064 ----NDSFGASKPSIDDGLMEVVGL-TTYQLP---MLQAGMHGTCICQCRKARIITKRTIPMQVD 1120
                :|.|.|  ||.||.::|||.: .:.|:.   :::...|....|:..|..|.....:|:|||
Human   862 GTKEDDIFAA--PSFDDKILEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVD 924

  Fly  1121 GEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNPLEKMQLHILRVTMQQYEQYHYDKEMLRKL 1185
            |||....|.:|:|...|:|.||::.:                 ....|::.:|    ||:
Human   925 GEAWVQPPGIIKIVHKNRAQMLTRDR-----------------AFESTLKSWE----DKQ----- 963

  Fly  1186 ANKLGQIEIESQCDLEHVRNMLNTKFEESISYPKVSQDWCFIDSCTAEHYFRIDRAQEHLH--YI 1248
                       :||                |...|.:...:|       :..||.|.|.:.  .:
Human   964 -----------KCD----------------SGKPVLRTHLYI-------HHAIDLATEEVSQMQL 994

  Fly  1249 CDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQAQGRGPGSTDED-------- 1305
            |..|.:||.....:|||:....:||.:.|..:...|.|      :|..|.|.|...|
Human   995 CSQAAEELITRICDAATIHCLLEQELAHAVNACSHALN------KANPRCPESLTRDTATEIAIN 1053

  Fly  1306 ----------LQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLNMLRALHEQGYSLQ------- 1353
                      |.:|..|:::   :||..|:.|:|  |.:...:|..|..:....|.|.
Human  1054 VKALYNETESLLVGRVPLQL---ESPHEERVSNA--LHSVEVELQKLTEIPWLYYILHPNEDEEP 1113

  Fly  1354 ----SVNKNGQTALHFACKYNHRDIVKYIIAS------------ATRRLINMAD-KEL------- 1394
                :...|..|......|:....:.|...:|            |...|:|:.: |::
Human  1114 PMDCTKRNNRSTVFRIVPKFKKEKVQKQKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIR 1178

  Fly  1395 GQTALHIAAEQNRRDICVMLVAAGAHLDTL-----DSGGNTP 1431
            |...||:    .|||:..:.:....|:..:     :.|.:||
Human  1179 GAELLHL----ERRDLKDLGIPKVGHVKRILQGIKELGRSTP 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	12/51 (24%)
		C1_1	661..725	CDD:278556	14/68 (21%)
		LCB5	813..1140	CDD:224513	159/623 (26%)
		DAGKc	814..942	CDD:214487	67/128 (52%)
		DAGKa	969..1123	CDD:214486	67/162 (41%)
		ANK	1329..1447	CDD:238125	25/139 (18%)
		ANK repeat	1329..1356	CDD:293786	6/37 (16%)
		Ank_2	1330..1425	CDD:289560	21/130 (16%)
		ANK repeat	1358..1391	CDD:293786	8/44 (18%)
		ANK repeat	1393..1425	CDD:293786	7/43 (16%)
		Ank_2	1399..>1459	CDD:289560	9/38 (24%)
DGKH	NP_821077.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60		18/80 (23%)
		PH_DGK_type2	67..163	CDD:270093	18/100 (18%)
		PH	67..156	CDD:278594	16/93 (17%)
		C1	176..225	CDD:237996	12/52 (23%)
		C1	248..293	CDD:197519	14/62 (23%)
		DAGKc	334..456	CDD:214487	67/128 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..617		4/35 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..705		3/68 (4%)
		DAGKa	770..927	CDD:214486	67/162 (41%)
		SAM_DGK-eta	1147..1211	CDD:188975	11/67 (16%)
		SAM	1148..1211	CDD:197735	11/66 (17%)
		PDZ-binding	1218..1220
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840