DRSC/TRiP Functional Genomics Resources

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Protein Alignment rdgA and DGKB

DIOPT Version :9

Sequence 1:NP_001259366.1 Gene:rdgA / 31826 FlyBaseID:FBgn0261549 Length:1462 Species:Drosophila melanogaster
Sequence 2:NP_001337634.1 Gene:DGKB / 1607 HGNCID:2850 Length:804 Species:Homo sapiens


Alignment Length:609 Identity:213/609 - (34%)
Similarity:287/609 - (47%) Gaps:113/609 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   584 ENAVQ--GEHYW------KPTSASGDLCCLNEECIKSGQRMKCSACQLVAHHNCIPFVNEKSTLA 640
            ||.|:  |:|.|      ||...:   .|||.......|.:.||.|:...|..|:    .::..:
Human   236 ENNVKDDGQHVWRLKHFNKPAYCN---LCLNMLIGVGKQGLCCSFCKYTVHERCV----ARAPPS 293

  Fly   641 CKPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCH 705
            |..||    ::..|.....||:||...... ||.:|.|.....|.          :..|.|.||.
Human   294 CIKTY----VKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCYQG----------LTGLHCVWCQ 343

  Fly   706 EIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIV-----KLPTKGNFKSSIRVSNKNNAASGSG 765
            ...|||  |.:..|  .||..|.....|:||:.|.     .|||.|......|.|......||| 
Human   344 ITLHNK--CASHLK--PECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGS- 403

  Fly   766 GGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRA---------FIVKPIPSPEVIPVIVFINPKS 821
                               |:..|..::.|..||         ..|.|:|...  |::||:||||
Human   404 -------------------QQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTH--PLLVFVNPKS 447

  Fly   822 GGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQP 886
            ||.||.::..|||:|||||||:.|:..||..||:.||..|:.|||||||||||||||..:::.. 
Human   448 GGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKAN- 511

  Fly   887 PLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPND 951
             :...|.|.:|||||||||||.|.|||     ||..|.:.|||::|..|..:::|||:.:|.|||
Human   512 -VGKHPPVAILPLGTGNDLARCLRWGG-----GYEGENLMKILKDIENSTEIMLDRWKFEVIPND 570

  Fly   952 DVTDDHVDRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLI 1016
            .      |.....||.::||||||.||||.||..||..||.|||:||||::||.:|.:.|..:..
Human   571 K------DEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETF 629

  Fly  1017 LRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDS-----------FGAS 1070
            ....:.|.:.|.:||||...  .|.:.....:..|||||..||::.|.:|           .|:.
Human   630 SATCKKLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSD 692

  Fly  1071 K--------------PSIDDGLMEVVGLT-TYQLPMLQAGMH--GTCICQCRKARIITKRTIPMQ 1118
            |              ..:.|.|:|||||. ..::..:..|:.  |..:.||....|.|.:::|||
Human   693 KRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQ 757

  Fly  1119 VDGEACRVKPSVIEIELLNKALML 1142
            :|||.....|..|:|...|:|.||
Human   758 IDGEPWMQTPCTIKITHKNQAPML 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdgANP_001259366.1 C1_1 591..640 CDD:278556 13/54 (24%)
C1_1 661..725 CDD:278556 18/63 (29%)
LCB5 813..1140 CDD:224513 146/354 (41%)
DAGKc 814..942 CDD:214487 68/127 (54%)
DAGKa 969..1123 CDD:214486 63/181 (35%)
ANK 1329..1447 CDD:238125
ANK repeat 1329..1356 CDD:293786
Ank_2 1330..1425 CDD:289560
ANK repeat 1358..1391 CDD:293786
ANK repeat 1393..1425 CDD:293786
Ank_2 1399..>1459 CDD:289560
DGKBNP_001337634.1 DAG_kinase_N 6..149 CDD:373103
EFh 153..222 CDD:238008
C1 245..294 CDD:237996 13/55 (24%)
C1_1 310..359 CDD:365894 18/63 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..406 7/40 (18%)
DAGKc 440..561 CDD:214487 68/127 (54%)
DAGKa 582..762 CDD:214486 63/181 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..694 3/20 (15%)
Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522 771..804 5/11 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155659
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000241
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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