Protein Alignment rdgA and DGKA

DIOPT Version :9

• Sequence 1: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_016874389.1
• Gene: DGKA / 1606
• HGNCID: 2849
• Length: 891
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 201/590 - (34%)
• Similarity: 291/590 - (49%)
• Gaps: 109/590 - (18%)

  Fly   589 GEHYWKPTSASGDLCC-LNEECIKSG-QRMKCSACQLVAHHNCIPFVNEKSTLACK-PTY----R 646
            |:|.|:|......:.| |.|..|..| |.:.|:.|:...|..|     ....|.|: .||    :
Human   360 GQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQC-----AMKALPCEVSTYAKSRK 419

  Fly   647 DVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNK 711
            |:|::.        |.||....|.|:|.:|          |.|:.....:..|.|.|||...|
Human   420 DIGVQS--------HVWVRGGCESGRCDRC----------QKKIRIYHSLTGLHCVWCHLEIH-- 464

  Fly   712 EACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGG 776
            :.|. || :|.||..|.....|:|||.|.         .|:..|
Human   465 DDCL-QA-VGHECDCGLLRDHILPPSSIY---------PSVLAS--------------------- 497

  Fly   777 GGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQ 841
             |..:|.::..||..::.....:..::..|.|...|::||:||||||.||.::|.|||::|||||
Human   498 -GPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQ 561

  Fly   842 VFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLA 906
            ||:|.:.||::||.:|:..|:.|:|.|||||||||:|..:|:...|:  .|.|.|||||||||||
Human   562 VFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPV--LPPVAVLPLGTGNDLA 624

  Fly   907 RALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVIN 971
            |.|.|||     ||..:.:.|||:::.||:.|.||||.|:|.|..  |:   ::|.| ||..:||
Human   625 RCLRWGG-----GYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQ--TE---EKSDP-VPFQIIN 678

  Fly   972 NYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDF 1036
            ||||.||||.||..||..||.:||:||||::||::|.:....:.|....:.|.:.:|:|..|:..
Human   679 NYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPL 743

  Fly  1037 TGKLRDAGCHAVLFLNIPSYGGGTHPW-------------NDSFGASK-------------PSID 1075
              .|.:.....:..|||||..||::.|             |.:.||:.             |.:.
Human   744 --DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLS 806

  Fly  1076 DGLMEVVGLT-TYQLPMLQAGMH--GTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLN 1137
            |..:|||||. ..::..:...:.  |..:.:|.:....|.:|:|||:|||.....|..|:|...|
Human   807 DKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKN 871

  Fly  1138 KALML 1142
            :..||
Human   872 QMPML 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	13/50 (26%)
		C1_1	661..725	CDD:278556	20/63 (32%)
		LCB5	813..1140	CDD:224513	143/355 (40%)
		DAGKc	814..942	CDD:214487	69/127 (54%)
		DAGKa	969..1123	CDD:214486	58/182 (32%)
		ANK	1329..1447	CDD:238125
		ANK repeat	1329..1356	CDD:293786
		Ank_2	1330..1425	CDD:289560
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
		Ank_2	1399..>1459	CDD:289560
DGKA	XP_016874389.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910