DRSC/TRiP Functional Genomics Resources

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Protein Alignment rdgA and DGKK

DIOPT Version :9

Sequence 1:NP_001259366.1 Gene:rdgA / 31826 FlyBaseID:FBgn0261549 Length:1462 Species:Drosophila melanogaster
Sequence 2:NP_001013764.1 Gene:DGKK / 139189 HGNCID:32395 Length:1271 Species:Homo sapiens


Alignment Length:1399 Identity:283/1399 - (20%)
Similarity:455/1399 - (32%) Gaps:532/1399 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 PQPTTPCGITFTLSPTNGDYPSPPHLPLDPGSPPI----------SPCSSNSGRLPALAPIISTP 389
            |:|..|             :|.||..|..|.:||:          .||       |.|||   .|
Human    24 PEPPPP-------------WPPPPPPPAPPPAPPLLSEASPEPIPEPC-------PELAP---GP 65

  Fly   390 CSSADADDAGAAMGLPVRARRRSISRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVD--TADSLD 452
            |..|.::.|                  ..::.|||.......:.|......|:.:.:  |..:.:
Human    66 CPEATSESA------------------TELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAPE 112

  Fly   453 EASTMATCGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASV-----DSCFSKLSSNAKT 512
            .|...||..:|.........|....|          |:|..:.|..:     ....::|:.....
Human   113 PAPEPATESAPEPTPEPALESVPEPA----------PELTPEVAPELAPEPTPEPVTELAPEFCP 167

  Fly   513 E---ELQPSADGCFLTVP----------------------------------------NINATRS 534
            |   |.:||...|.|..|                                        |.|:.:.
Human   168 EAAPEFRPSPAPCLLQCPVDTRERGLKTSPSPSPSPSPRTPMSWSRIKKILKEGPMLKNCNSFKR 232

  Fly   535 RSVDIVLPTDEQ---------ARYKALSMTGSTVTYADGRTASAS----NSRRPIRI-------V 579
            ..:...|...::         |.::.:.::.:||..:..|....|    ..:|.|.:       :
Human   233 WKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCRNLCHSFCVITPQRKITLAAPNRKDM 297

  Fly   580 PDW---TENAVQGEHYWKPTSASGDL-----------------CCLNEECIKSGQR--MKCSACQ 622
            .:|   .:...|||.|..|.:.:...                 |.:..|.|.:..|  :.|..|:
Human   298 EEWINIIKTIQQGEIYKIPAAENNPFLVGMHCWYSSYSHRTQHCNVCRESIPALSRDAIICEVCK 362

  Fly   623 LVAHHNCIPFVNEKSTLACKPTYRDVGIRQ----YREQTTTHHHWVHRKLE-KGKCKQCGKFFPM 682
            :.:|..|.    .:::..||  :..:.|..    ..::....|.||...:. ..:|..|.:....
Human   363 VKSHRLCA----LRASKDCK--WNTLSITDDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGS 421

  Fly   683 KQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGN 747
            .|.:|.          ..|.||:...|  :.|  :.:..:||...::...::||:.:......|.
Human   422 YQRLQD----------FRCLWCNSTVH--DDC--RRRFSKECCFRSHRSSVIPPTALSDPKGDGQ 472

  Fly   748 FKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIP 812
            ...|....|.:.:::.|                                              .|
Human   473 LVVSSDFWNLDWSSACS----------------------------------------------CP 491

  Fly   813 VIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWV 877
            :::|||.|||.:||...|.||:..|||.|||||.:|||:.||.||:.....|:|.|||||:|.||
Human   492 LLIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWV 556

  Fly   878 LSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDR 942
            ||::|..  .|.....:.|:||||||||||.||||.   |...:..|: .||..:..:...::||
Human   557 LSLIDAF--GLHEKCQLAVIPLGTGNDLARVLGWGA---FWNKSKSPL-DILNRVEQASVRILDR 615

  Fly   943 WRVKV------TP---------------------------------------------------N 950
            |.|.:      ||                                                   .
Human   616 WSVMIRETPRQTPLLKGQVEMDVPRFEAAAIQHLESAATELNKILKAKYPTEMIIATRFLCSAVE 680

  Fly   951 DDVTD--------------------------------------------------DHVDRS---- 961
            |.|.|                                                  ::.|.|    
Human   681 DFVVDIVKAWGQIKQNNTAIVSVILKSDLMYDRLSVLIDVLAEEAAATSAEKSATEYADSSKADR 745

  Fly   962 KPNVP------------------------------------------------------------ 966
            ||.:|                                                            
Human   746 KPFIPQIDHIAKCKLELATKAQSLQKSLKLIIFQVEQALDEESRQTISVKNFSSTFFLEDDPEDI 810

  Fly   967 ---------------------------LN-----------------VINNYFSFGVDAHIALEFH 987
                                       ||                 |:||||..|:||.|:|:|:
Human   811 NQTSPRRRSRRGTLSSISSLKSEDLDNLNLDHLHFTPESIRFKEKCVMNNYFGIGLDAKISLDFN 875

  Fly   988 EAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAGCHAVLFLN 1052
            ..|:.||.::||||:|||:||.:|.|:|:.|.||.|.:.|.|||||:    .:.......::.||
Human   876 TRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVHLECDGE----TISLPNLQGIVVLN 936

  Fly  1053 IPSYGGGTHPWNDSFGASK---PSIDDGLMEVVGL-TTYQLPMLQ-AGMHGTCICQCRKARIIT- 1111
            |.||.||.:.|..:...::   |:||||.:|||.: .:.|:.|.: ..:|...|.||.:..|.. 
Human   937 ITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIFGSVQMAMSRIINLHHHRIAQCHEVMITID 1001

  Fly  1112 -KRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRK----------HGRGDVQVNPLEKMQLHIL 1165
             :..||:||||||...:|.:|:|...|.|.||::.:          :...::|..|..::.....
Human  1002 GEEGIPVQVDGEAWIQRPGLIKIRYKNAAQMLTRDRDFENSMKMWEYKHTEIQAAPQPQLDFQDS 1066

  Fly  1166 RVTM--QQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHV----------RNMLNTKFEESISYP 1218
            :.::  ::|.|..:...:...|.:||..:....|    ||          .|:||..|....|..
Human  1067 QESLSDEEYAQMQHLARLAENLISKLNDLSKIHQ----HVSVLMGSVNASANILNDIFYGQDSGN 1127

  Fly  1219 KVSQDWCF-IDSCTAEHYFRIDRAQEHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQR 1282
            ::....|. |::.:......:..:.:.|:......:||..:...|..|..|           |..
Human  1128 EMGAASCIPIETLSRNDAVDVTFSLKGLYDDTTAFLDEKLLRSAEDETALQ-----------SAL 1181

  Fly  1283 QAQNERRQMDQAQGRGPGSTDEDLQIGSKPIKVMKWKSPIL---EQTSDAILLAAQSGDLNMLR- 1343
            .|.|:.                     .|.:..:.|.:||.   |::||.        |...|| 
Human  1182 DAMNKE---------------------FKKLSEIDWMNPIFVPEEKSSDT--------DSRSLRL 1217

  Fly  1344 -----ALHEQGYSLQSVNKNGQTALHFACKYNHR 1372
                 .|.::....:...|:||:...|.....||
Human  1218 KIKFPKLGKKKVEEERKPKSGQSVQSFIGNLWHR 1251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdgANP_001259366.1 C1_1 591..640 CDD:278556 10/67 (15%)
C1_1 661..725 CDD:278556 13/64 (20%)
LCB5 813..1140 CDD:224513 146/548 (27%)
DAGKc 814..942 CDD:214487 59/127 (46%)
DAGKa 969..1123 CDD:214486 65/160 (41%)
ANK 1329..1447 CDD:238125 10/50 (20%)
ANK repeat 1329..1356 CDD:293786 4/32 (13%)
Ank_2 1330..1425 CDD:289560 10/49 (20%)
ANK repeat 1358..1391 CDD:293786 5/15 (33%)
ANK repeat 1393..1425 CDD:293786
Ank_2 1399..>1459 CDD:289560
DGKKNP_001013764.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..160 35/186 (19%)
33 X 4 AA approximate tandem repeats of E-P-A-P 48..179 30/168 (18%)
SPRR2 <123..185 CDD:291486 13/71 (18%)
Trypan_PARP <123..>179 CDD:114603 11/65 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 190..209 0/18 (0%)
PH 217..305 CDD:278594 11/87 (13%)
PH_DGK_type2 218..314 CDD:270093 14/95 (15%)
C1 328..377 CDD:237996 8/52 (15%)
C1 399..449 CDD:237996 12/63 (19%)
DAGKc 493..615 CDD:214487 59/127 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 805..825 0/19 (0%)
DAGKa 857..1014 CDD:214486 65/160 (41%)
Required for localization to the plasma membrane. /evidence=ECO:0000269|PubMed:16210324 1199..1268 15/61 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1252..1271 283/1399 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155645
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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