DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgA and Dgka

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_036011466.1	Gene:	Dgka / 13139	MGIID:	102952	Length:	788	Species:	Mus musculus

Alignment Length:	647	Identity:	212/647 - (32%)
Similarity:	298/647 - (46%)	Gaps:	142/647 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 SRSVDIVLPTDEQARYKA-----LSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYW 593
            |.||.:    ||..|..|     |.:.|..||..|                        .|.|.|
Mouse   231 SGSVSL----DEWVRAGATTVPLLVLLGMDVTMKD------------------------DGNHIW 267

  Fly   594 KPTSASGDLCC-LNEECIKSG-QRMKCSACQLVAHHNCIPFVN--EKSTLACKPTYRDVGIRQYR 654
            :|...:..:.| |.|:.|..| |.:.|:.|:.:.|.:|.....  |.||.|  .:.:|:|::.
Mouse   268 RPKRFTRLVYCNLCEQSISLGKQGLSCNFCKYIVHDHCAMKAQPCEVSTYA--KSRKDIGVQS-- 328

  Fly   655 EQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAK 719
                  |.||......|:|.:|          |.|:.....:..|.|.|||...|  :.|. ||
Mouse   329 ------HLWVRGGCHSGRCDRC----------QKKIRTYHSLTGLHCVWCHLEIH--DDCL-QA- 373

  Fly   720 IGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQT 784
            :|.||..|.....|:||..|.         .|:.||                     |.:.|.:|
Mouse   374 VGPECDCGLLRDHILPPCSIY---------PSVLVS---------------------GQECKHKT 408

  Fly   785 QRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGG 849
                ........|.||.::|:.:..  |::||||.||||.||..:|.|||::||||||||| :.|
Mouse   409 ----TDDTSLCTPEAFRIEPVSNTH--PLLVFINLKSGGKQGQSVLWKFQYILNPRQVFDL-KDG 466

  Fly   850 PKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGS 914
            |:.||..|:..|..|:|.|||||||||||..:|:..  ....|.|.||||||||||||.|.||
Mouse   467 PEPGLRFFKDVPQFRILVCGGDGTVGWVLETIDKAN--FATVPPVAVLPLGTGNDLARCLRWG-- 527

  Fly   915 IFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNVINNYFSFGVD 979
               :||..|.:.|||::|.:|:.|.:|||.::|.|     ..:.::|.| ||..:||||||.|||
Mouse   528 ---RGYEGENLRKILKDIELSKVVYLDRWFLEVIP-----QQNGEKSDP-VPSQIINNYFSIGVD 583

  Fly   980 AHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDAG 1044
            |.||..||..||.:||:||||::||::|.:....:.|....:.|.:.||:|..|:..  .|.|..
Mouse   584 ASIAHRFHLMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESVTVEICGKLL--DLSDLS 646

  Fly  1045 CHAVLFLNIPSYGGGTHPWNDS--------------FGASK------------PSIDDGLMEVVG 1083
            ...:..|||||..||::.|.|:              ..|:|            |.:.|..:||||
Mouse   647 LEGIAVLNIPSTHGGSNLWGDTKRPHGDTCEINQALGSAAKIITDPDILKTCVPDMSDKRLEVVG 711

  Fly  1084 LT-TYQLPMLQAGMH--GTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALML 1142
            :. ..::..:...:.  |..:.:|.:....|.:|:|||:|||.....|..|:|...|:..||
Mouse   712 IEGAIEMGQIYTRLKSAGHRLAKCSEITFQTTKTLPMQIDGEPWMQAPCTIKITHKNQMPML 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	16/52 (31%)
		C1_1	661..725	CDD:278556	19/63 (30%)
		LCB5	813..1140	CDD:224513	142/355 (40%)
		DAGKc	814..942	CDD:214487	69/127 (54%)
		DAGKa	969..1123	CDD:214486	59/182 (32%)
		ANK	1329..1447	CDD:238125
		ANK repeat	1329..1356	CDD:293786
		Ank_2	1330..1425	CDD:289560
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
		Ank_2	1399..>1459	CDD:289560
Dgka	XP_036011466.1	DAG_kinase_N	39..169	CDD:405237
		EFh	173..242	CDD:238008	5/14 (36%)
		C1	260..320	CDD:412127	19/85 (22%)
		C1_DGKalpha_rpt2	329..390	CDD:410440	22/74 (30%)
		DAGKc	432..552	CDD:214487	69/127 (54%)
		DAGKa	573..754	CDD:214486	59/182 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840