DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgA and Dgkg

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_017172339.1	Gene:	Dgkg / 110197	MGIID:	105060	Length:	834	Species:	Mus musculus

Alignment Length:	880	Identity:	243/880 - (27%)
Similarity:	336/880 - (38%)	Gaps:	280/880 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 EPTGNSLENVSHEEVDNSNTKSSVDTADSLD-EASTMAT--------CGSPGAAGGSGASSSHHN 477
            |...:|..|||....||:   :..|.|.:.| |:.|..|        ..:|....|:.||||...
Mouse    93 EGASSSEPNVSDYNSDNA---AKADEACAPDTESKTTKTQAPSKELEAAAPWEDPGALASSSDAP 154

  Fly   478 AFVVRDI--YLMVPDLKRDR-------------------AASVDSCFSKLSSNA----------- 510
            ...::|:  ||.:.:..|.:                   .|.:|...|::...|
Mouse   155 VVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENGLLDQAEMDQIVSQMLHVAQYLEWDPTELR 219

  Fly   511 ---------------------------------KTEELQPSAD---------------------- 520
                                             :||:|:||.:
Mouse   220 PERCLRQQDEVYTWQKLQFPSLPSRGNSMIETQRTEKLEPSVEELSMILKEMLQGMDYDKDGFVS 284

  Fly   521 ------GCFLTVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASNSRRPIRIV 579
                  |...|:|.:         ::|..|:         :||.   .|||.|
Mouse   285 LQEWINGGMTTIPLL---------VLLGMDD---------SGSK---GDGRHA------------ 316

  Fly   580 PDWTENAVQGEHYWKPTSAS-----------GDLCCLNEECIKSGQRMKCSACQLVAHHNCIPFV 633
              ||.     :|:.|||..:           ..|||:              .|:...|..|:
Mouse   317 --WTL-----KHFKKPTYCNFCRAMLMGVGKQGLCCI--------------YCKYTVHQRCV--- 357

  Fly   634 NEKSTLACKPTYRDVGIRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVA 698
             .|:...|..|    ..:..|......|.||... ...||.:|.|.....|:|          .|
Mouse   358 -SKTIHGCVKT----NSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCYQSV----------TA 406

  Fly   699 LACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASG 763
            ..|.||...:|.|            |.|....             ..|..|..|.:.......||
Mouse   407 RHCVWCRMTFHRK------------CELSTVC-------------DGGELKDHILLPTSICPVSG 446

  Fly   764 SGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHK 828
            ...||...|:....|:...|                  .|.||||...|::|.:||||||.||.:
Mouse   447 DRQGGKSDGSVAAKGELVTQ------------------YKIIPSPGTHPLLVLVNPKSGGRQGER 493

  Fly   829 LLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPA 893
            :|.||.:||||.|||:|..|||..||:.|...|:.|||||||||||||:|..:|:..  ....|.
Mouse   494 ILRKFHYLLNPEQVFNLDNGGPTPGLNFFHDTPDFRVLACGGDGTVGWILDCIDKAN--FTKHPP 556

  Fly   894 VGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHV 958
            |.||||||||||||.|.|||     ||....:.|||:||..|..|::|||.::|.|.::|
Mouse   557 VAVLPLGTGNDLARCLRWGG-----GYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEV----- 611

  Fly   959 DRSKPNVPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNL 1023
             .:...||.|::|||||.||||.||..||..||.|||:||||::||::|.:.|..:......:.|
Mouse   612 -ENGDQVPYNIMNNYFSIGVDASIAHRFHMMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKL 675

  Fly  1024 SQWVTLECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDS------FGASKPSI-------- 1074
            ...:.|||||.:.  .|.:.....:..|||||..|||:.|.::      ...|:.|:
Mouse   676 HDHIELECDGVEV--DLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRKSVTDPKELKC 738

  Fly  1075 -----DDGLMEVVGLT-TYQLPMLQAGMH--GTCICQCRKARIITKRTIPMQVDGEACRVKPSVI 1131
                 .|.|:|||||. ..::..:..|:.  |..:.||....|.|.:.:|||||||........|
Mouse   739 CVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTNKLLPMQVDGEPWMQPQCTI 803

  Fly  1132 EIELLNKALMLSKRKHGRGDVQVNPLEKMQLHILR 1166
            :|...|:|.|:           :.|.:|.....||
Mouse   804 KITHKNQAPMM-----------MGPPQKSSFFSLR 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	11/59 (19%)
		C1_1	661..725	CDD:278556	15/63 (24%)
		LCB5	813..1140	CDD:224513	145/348 (42%)
		DAGKc	814..942	CDD:214487	69/127 (54%)
		DAGKa	969..1123	CDD:214486	63/175 (36%)
		ANK	1329..1447	CDD:238125
		ANK repeat	1329..1356	CDD:293786
		Ank_2	1330..1425	CDD:289560
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
		Ank_2	1399..>1459	CDD:289560
Dgkg	XP_017172339.1	DAG_kinase_N	5..172	CDD:373103	22/81 (27%)
		EFh	176..291	CDD:238008	9/114 (8%)
		C1	315..364	CDD:237996	14/85 (16%)
		C1	379..420	CDD:197519	15/63 (24%)
		DAGKc	479..600	CDD:214487	69/127 (54%)
		DAGKa	621..795	CDD:214486	63/175 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840