Protein Alignment rdgA and dgkk

DIOPT Version :10

• Sequence 1: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_004916836.1
• Gene: dgkk / 100496859
• XenbaseID: XB-GENE-22063413
• Length: 1154
• Species: Xenopus tropicalis
• Alignment Length: 1192
• Identity: 272/1192 - (22%)
• Similarity: 403/1192 - (33%)
• Gaps: 506/1192 - (42%)

  Fly   493 RDRAASVDSCFSKL---------SSNAKTEELQPSADGCFLTVPNINATRS-RSVD---IVLPTD 544
            ||..:|:||  .||         ||:::.||.:..:......|......|| :||.   ::..|.
 Frog    16 RDSVSSLDS--DKLPTAEATGEESSDSEGEEQEGISHKLIRKVSTSGQIRSKKSVKEGILLKQTS 78

  Fly   545 EQARYKA--LSMTGSTVTYA--------------DGRTASAS---------------------NS 572
            ...|:|.  ..:.|.|:.||              |...|..|                     .:
 Frog    79 SFQRWKRRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAETSTKNINNSFTVITPFRKLILCAEN 143

  Fly   573 RR-------PIRIVPDWTENAV--------QGEHYWKPTS-ASGDLCCLNEECIK--SGQRMKCS 619
            |:       .::.|..|..|..        .|.|.|...| |....|.:..|.:.  :...:.|.
 Frog   144 RKEMEDWIGALKSVQKWELNETTQFNMEHFSGMHNWYACSHARPTFCNVCREALSGVTSHGLSCE 208

  Fly   620 ACQLVAHHNCIPFVNEKSTLACK-PTYRDVG--IRQYREQTTTHHHWVHRKLE-KGKCKQCGKFF 680
            .|:..||..|.    .::|..|| .|...||  |.:..:..:..|.|:...|. ..||:.|
 Frog   209 VCKFKAHKRCA----VRATNNCKWTTLASVGNDIIEDEDGVSMPHQWLEGNLPVSAKCEVC---- 265

  Fly   681 PMKQAVQSKLFGS-KEIVALACAWCHEIYHNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPT 744
                   .|..|| :.:....|.||..|.|.  :|..|  :|:.|.||.....|:||..:..:.:
 Frog   266 -------DKTCGSVRRLQDWRCLWCKAIVHT--SCKEQ--LGKICPLGPCRVSIIPPIALNSIDS 319

  Fly   745 KGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQTQRRQKGKEEKKEPRAFIVKPIPSPE 809
            .|.:|::                                                     .|:..
 Frog   320 DGFWKAT-----------------------------------------------------SPASC 331

  Fly   810 VIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTV 874
            ..|::||:|.|||.|||.|.|.||:..|||.|||||..|||::||.:|:|..|.|:|.|||||:|
 Frog   332 ASPLLVFVNSKSGDNQGVKFLRKFKQFLNPAQVFDLMNGGPQLGLRLFQKFSNFRILVCGGDGSV 396

  Fly   875 GWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVL 939
            |||||.:|::  .||....:|||||||||||||.||||...    ..|..:.:||.::..:...:
 Frog   397 GWVLSEIDKL--GLQKQCQLGVLPLGTGNDLARVLGWGSLC----DDDAQLLQILEKLERATTKM 455

  Fly   940 MDRWRV------KVTP------------------------------------------------- 949
            :|||.:      |.:|
 Frog   456 LDRWSILTYESPKHSPPAIREEENGEAKFQVQISQYADSVAFHLAKILESDKHCDVISSAKFLCL 520

  Fly   950 --NDDVTD---------------DHVDR------------------------------------- 960
              ||.:|:               |::.|
 Frog   521 SVNDFITEVGKAYARAAENREEADNMARKCSMLNEKLESLVRSLNEESQALLAPPLQSLHPDSAL 585

  Fly   961 -----------------------------------------------------------SKPNV- 965
                                                                       |.|.:
 Frog   586 KENSKDVNEKENNMEDMAKIFKSKEQLMLRANSLKKALKQIIEQAEKAVDEQNKHTQVYSTPMLS 650

  Fly   966 ----------------------------------------PLN------------VINNYFSFGV 978
                                                    ||:            .:||||..|:
 Frog   651 PIQKESSEEFSKEGESLASRRGTISSTTSSIILDRPYTFSPLHFSEDAIQFSERCTMNNYFGIGL 715

  Fly   979 DAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRDA 1043
            ||.|:|||:..|:.||::.:||.||.|:||.:|.|:|:.:.|:||.|.|.|||||:    .:...
 Frog   716 DAKISLEFNNKRDEHPKKCSSRTRNMMWYGVLGTKELLQKTYKNLEQRVKLECDGE----PISLP 776

  Fly  1044 GCHAVLFLNIPSYGGGTHPW-----NDSFGASKPSIDDGLMEVVGL-TTYQLPMLQA-GMHGTCI 1101
            ....:..||||||.||.:.|     :::|||  ||.||..:|||.: .:.|:.:.:. .:....|
 Frog   777 SLQGIAVLNIPSYAGGINFWGGTKEDNNFGA--PSFDDKKLEVVAVFGSIQMAVSRVINLQHHRI 839

  Fly  1102 CQCR--KARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLS--------------KRKHGRG 1150
            .|||  |..|:.:..:|:||||||....|.:::|:..|:|.||:              |||....
 Frog   840 AQCRVVKITILGEEGVPVQVDGEAWVQPPGILKIQHKNRAQMLTRDRAFENTLKSWEDKRKGDSY 904

  Fly  1151 DVQVNPLEKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEESI 1215
            .|...|         |:..||..:|..::|.                ..|:|:.|
 Frog   905 RVMARP---------RLHSQQSMEYLTEEEF----------------AHLQHLAN---------- 934

  Fly  1216 SYPKVSQDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILDHEAATMPQTPDQERSFA--- 1277
                           |:|:.  |.|.:|...|             |:|.      :||.:.|
 Frog   935 ---------------TSENL--ISRIREAAKY-------------HKAV------EQELAHAVNG 963

  Fly  1278 -------AFSQRQAQNERRQMDQAQGRGPGSTDEDLQIGSKPI---------KVMKWKSPILEQT 1326
                   |||     |:.....:...|   :|..|:.|..|.:         ...:|:||   |.
 Frog   964 SFGVLNEAFS-----NKTNNSPELLSR---NTAVDVAISVKALYTETKAFLESKQQWESP---QE 1017

  Fly  1327 SDAIL--LAAQSGDLNMLRALH 1346
            .:.:|  |.|...||..|..:|
 Frog  1018 EEGLLCSLNAVGQDLERLADIH 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_DGK_typeIV_rpt1	586..647	CDD:410352	16/72 (22%)
		C1_DGK_typeIV_rpt2	661..727	CDD:410405	18/67 (27%)
		DAGKc	814..942	CDD:214487	65/127 (51%)
		DAGKa	969..1123	CDD:214486	65/162 (40%)
		ANKYR	<1329..1452	CDD:440430	7/20 (35%)
		ANK repeat	1329..1356	CDD:293786	7/20 (35%)
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786
dgkk	XP_004916836.1	PH_DGK_type2	68..164	CDD:270093	14/95 (15%)
		C1	148..233	CDD:412127	19/88 (22%)
		C1_DGKeta_rpt2	244..305	CDD:410444	20/75 (27%)
		DAGKc	336..458	CDD:214487	65/127 (51%)
		DAGKa	706..863	CDD:214486	65/162 (40%)
		SAM_superfamily	1087..1150	CDD:472832