Protein Alignment rdgA and dgki

DIOPT Version :10

• Sequence 1: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_031754398.1
• Gene: dgki / 100491416
• XenbaseID: XB-GENE-996218
• Length: 1095
• Species: Xenopus tropicalis
• Alignment Length: 1089
• Identity: 411/1089 - (37%)
• Similarity: 559/1089 - (51%)
• Gaps: 227/1089 - (20%)

  Fly   464 GAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPN 528
            ||..|||:|||                     |:|.||...|..|.:..:.|.|:  .|    |.
 Frog   125 GAGEGSGSSSS---------------------ASSSDSESGKAISRSGLQHLAPA--HC----PV 162

  Fly   529 INATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYW 593
            .|.          |..|                              :|:..||||||:.|||.|
 Frog   163 SNG----------PAKE------------------------------LRMTLDWTENAINGEHLW 187

  Fly   594 KPTSASGDLCCLNEE-C----IKSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQY 653
            :.|:.|||||.|.|| |    .||..|.||:||::|.|..|:..: :|....||||:||...|..
 Frog   188 QETNVSGDLCYLGEENCQVKFAKSAIRRKCAACKIVVHTACMEQL-DKINFRCKPTFRDGTSRTP 251

  Fly   654 RE----------QTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIY 708
            ||          |....||||||:.::||||||||.|..|.:     |.||||||::|:||.:.:
 Frog   252 REVRHFSCCSNQQNLVRHHWVHRRRQEGKCKQCGKGFQQKFS-----FHSKEIVAISCSWCKQAF 311

  Fly   709 HNKEACFNQAKIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGA 773
            |||..||....|.|.|.||.:|.:|||||||:|:       ...:|:.||:.
 Frog   312 HNKVTCFLLHHIEEPCSLGAHAAVIVPPSWIIKV-------KKPQVNTKNST------------- 356

  Fly   774 GGGGGKSKKQT--QRR--QKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQ 834
                 :.||:|  :||  :||.|:.| .||||:|||.||.:.|::||:|||||||||.|:|..|.
 Frog   357 -----RRKKRTSFKRRASKKGLEDIK-GRAFIIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFM 415

  Fly   835 HLLNPRQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPL 899
            ..|||||||||:|.||:..|:|:||.||||:|||||||||||:|||||::|  |.|.|.|.||||
 Frog   416 WYLNPRQVFDLSQEGPRGALEMYRKVPNLRILACGGDGTVGWILSVLDELQ--LNPQPPVAVLPL 478

  Fly   900 GTGNDLARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPN 964
            ||||||||.|.|||     ||||||:.|||..:.....|.:|||.:.|..|.|:..:.:|.....
 Frog   479 GTGNDLARTLNWGG-----GYTDEPVSKILCHVEDGTNVQLDRWNLHVERNPDLLHEELDDGTHK 538

  Fly   965 VPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTL 1029
            :||||.|||||.|.|||:.|||||:|||:||:||||.||||:|......|.:.|..|:||:.|.:
 Frog   539 LPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKV 603

  Fly  1030 ECDGQDFTGKLRDAGCHAVLFLNIPSYGGGTHPW---NDSFGASKPSIDDGLMEVVGLTTYQLPM 1091
            .|||.|.|.|:::.....::|||||.|..||.||   :|.........|||.:||:|.|...|..
 Frog   604 VCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPSDHRDFEPQRHDDGYIEVIGFTMASLAA 668

  Fly  1092 LQAGMHGTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNP 1156
            ||.|.||..:.|||:..::|.:.||||||||.||:.||:|.|.|.|:|.|:.|.|.......:|.
 Frog   669 LQVGGHGERLHQCREVTLLTYKAIPMQVDGEPCRLAPSLIRISLRNQANMVQKSKRRTSMPLLND 733

  Fly  1157 LEK-------------------------MQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIES 1196
            |.|                         :::.:.|:.:|:||..||:|:.||..:..||.|.:..
 Frog   734 LHKVHSADHRRVSAPPDSFSVPHSVPDRLRIRVNRIRLQEYEGLHYEKDKLRDASIPLGIIVVRG 798

  Fly  1197 QCDLEHVRNML--------------------NTKFEESISYPKVSQDWCFIDSCTAEHYFRIDRA 1241
            .||||..|..:                    ::.|...:|..:::..|||:|:.:|:.::||||:
 Frog   799 DCDLETCRMYIDRLQEDLHSVTPHRDHCQDHDSSFPRLLSAQRLNPRWCFLDATSADRFYRIDRS 863

  Fly  1242 QEHLHYICDIAIDELYILDHEAATMPQ----------------------TPDQERSFAAFS---- 1280
            |||||::.:|:.||::|||.||...||                      ||...:...:.|
 Frog   864 QEHLHFVTEISQDEIFILDPEADGTPQGSTGMGMPDLVVEQPSGPSEWWTPTSRKRIVSDSCVAG 928

  Fly  1281 ----QRQAQNERRQMDQAQGR-GPGSTDEDLQIGSKPIKVMKWKSPILEQTSDAILLAAQSGDLN 1340
                |.:..::...:.....| .|.|.||                       .|:..|..:|||.
 Frog   929 RMSLQYEISDKVHDLSPCSARLSPVSVDE-----------------------QALTEAVAAGDLA 970

  Fly  1341 MLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVKYIIASATRRLINMADKELGQTALHIAAEQ 1405
            .:....::|.||:.......:.||.|.:..|.|||.||:.:....|::|:|:..|:||||.||..
 Frog   971 KVTECCKKGMSLRIPGPERGSLLHLAARAGHSDIVAYILQNGPTDLLDMSDRATGETALHKAASH 1035

  Fly  1406 NRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQGTQ 1454
            ..|.:|.:||.|||.:...|:.||||...|.....:|:|:||::.|..|
 Frog  1036 GHRRVCQILVDAGACVIKKDAKGNTPFDKAQEAGDSELASYLDTCQAKQ 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_DGK_typeIV_rpt1	586..647	CDD:410352	30/65 (46%)
		C1_DGK_typeIV_rpt2	661..727	CDD:410405	34/65 (52%)
		DAGKc	814..942	CDD:214487	81/127 (64%)
		DAGKa	969..1123	CDD:214486	76/156 (49%)
		ANKYR	<1329..1452	CDD:440430	44/122 (36%)
		ANK repeat	1329..1356	CDD:293786	8/26 (31%)
		ANK repeat	1358..1391	CDD:293786	11/32 (34%)
		ANK repeat	1393..1425	CDD:293786	14/31 (45%)
dgki	XP_031754398.1	C1_DGKiota_rpt1	175..247	CDD:410400	37/72 (51%)
		C1_DGKiota_rpt2	267..341	CDD:410446	41/78 (53%)
		DAGKc	395..516	CDD:214487	81/127 (64%)
		DAGKa	543..700	CDD:214486	76/156 (49%)
		ANKYR	<959..1094	CDD:440430	46/126 (37%)
		ANK repeat	959..986	CDD:293786	8/26 (31%)
		ANK repeat	991..1021	CDD:293786	11/29 (38%)
		ANK repeat	1023..1055	CDD:293786	14/31 (45%)