DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and dgki

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_009298312.1	Gene:	dgki / 100331649	ZFINID:	ZDB-GENE-120327-1	Length:	968	Species:	Danio rerio

Alignment Length:	1060	Identity:	398/1060 - (37%)
Similarity:	558/1060 - (52%)	Gaps:	198/1060 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 CGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFL 524
            ||...|.|||.:.||      ..|:...:.|..:..|......:.|..|.:..:.|.|:
Zfish    33 CGKNAAMGGSDSLSS------FADMDDSLEDKLKGLAFRKQISYRKAISRSGLQHLGPA------ 85

  Fly   525 TVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQG 589
                                 |..:.|||                :...:.:|...||:||||.|
Zfish    86 ---------------------QNPFPALS----------------NGPAKELRNTVDWSENAVNG 113

  Fly   590 EHYWKPTSASGDLCCLNEE-CI----KSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVG 649
            :|.|..|:.||:||.|.|| |:    ||..|.||:||::|.|..||..: :|....||||:|:..
Zfish   114 DHLWLETNCSGELCYLGEETCVAKIAKSAPRRKCAACKIVVHTACIEEL-DKINFRCKPTFREGS 177

  Fly   650 IRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEAC 714
            .|..|:|....||||||:.::|||:||||.||      .|.|.||||||::|:||.:.:|||..|
Zfish   178 SRCLRDQNVLRHHWVHRRRQEGKCRQCGKSFP------QKFFHSKEIVAISCSWCKQAFHNKVTC 236

  Fly   715 FNQAKIGEECRLGNYAPIIVPPSWIVKL-PTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGG 778
            |...:|.|.|.||.:|.:|||||||:|: ..:.:||:|.|
Zfish   237 FMLHQIEEPCSLGAHAGVIVPPSWIIKVRKPQSSFKNSTR------------------------- 276

  Fly   779 KSKKQT--QRR--QKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNP 839
             .||:|  :||  :||.:|.|. |.|::||:|||.:.||:||:|||||||||.|||..|..:|||
Zfish   277 -RKKRTSFKRRASKKGTDESKW-RPFMLKPLPSPLMKPVLVFVNPKSGGNQGTKLLQMFMWILNP 339

  Fly   840 RQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGND 904
            ||||||:||||:..|:::||.||||:|||||||||||:||.||::|  :.|.|.|.|||||||||
Zfish   340 RQVFDLSQGGPRDALELYRKVPNLRILACGGDGTVGWILSALDELQ--MNPQPPVAVLPLGTGND 402

  Fly   905 LARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNV 969
            |||.|.|||     ||||||:.|:|..:.....|.:|||.::|   :.....| :.....:||||
Zfish   403 LARTLNWGG-----GYTDEPVSKVLCHVEDGSVVQLDRWNLQV---ERSVVQH-EEGTQKLPLNV 458

  Fly   970 INNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQ 1034
            .|||||.|.|||:.|||||:|||:||:||||.||||:|......|.:.|..|:||:.|.:.|||.
Zfish   459 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVRVVCDGT 523

  Fly  1035 DFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDS-----FGASKPSIDDGLMEVVGLTTYQLPMLQA 1094
            |.|.|:::.....::|||||.|..||.||.::     |...:.  |||.:||:|.|...|..||.
Zfish   524 DLTAKIQELKFQCIVFLNIPRYCAGTMPWGNTGDHRDFEPQRH--DDGCIEVIGFTMASLAALQV 586

  Fly  1095 GMHGTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNPL-- 1157
            |.||..:.|||:..|.|.:|:|:|||||.||:.||.:.|.|.|:|.|:.|.|.......:|.:
Zfish   587 GGHGDRLHQCREVLITTFKTLPVQVDGEPCRLAPSTLRISLRNQANMVQKSKRRTSVPLLNDIQK 651

  Fly  1158 -----------------------EKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCD 1199
                                   |:::|.:.|:.:|.|:...:|||.||.::..:|.:.:...||
Zfish   652 VCAADLRRLSAPPDSFSVPHAVPERLRLRVNRIGLQDYDSMQFDKERLRDISTAVGIVVVRGDCD 716

  Fly  1200 LEHVRNMLNTKFEESISYP----------------------KVSQDWCFIDSCTAEHYFRIDRAQ 1242
            ||..|..::...|:....|                      ::|.:|.|:||.:|:.::|||:||
Zfish   717 LETCRLYIDRLQEDLHQAPSAGHRVHYQDECAGLPRPSSAHRLSANWSFLDSTSADRFYRIDKAQ 781

  Fly  1243 EHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQ 1307
            ||||::.:|..||:|||||||..:.|.                           |.||..|
Zfish   782 EHLHFVTEICQDEVYILDHEAPAVSQV---------------------------RAPGMPD---- 815

  Fly  1308 IGSKPIKVMKWKSPILEQTSD--AILLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYN 1370
                   |:...|..:..|||  |:|.||..|||..:.:....|.||...:..|.||||.|..:.
Zfish   816 -------VVVEPSSGVPLTSDEQALLSAAAKGDLTAVSSSCRSGLSLLVRDAMGCTALHLAAHHG 873

  Fly  1371 HRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVA 1435
            |.|:|.:|:...::.::::.:::.|.||||.||.|.:||:|..|:.|||.....:..|.||...|
Zfish   874 HADVVSFILEHGSKLMLDLTERDTGDTALHKAAAQQQRDVCKRLLEAGASPHKTNFLGKTPKDCA 938

  Fly  1436 FNKNANEIATYLESKQGTQP 1455
            .:....|:|:.||.:...:|
Zfish   939 LDAGNLELASMLEIQAVDEP 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	23/53 (43%)
		C1_1	661..725	CDD:278556	33/63 (52%)
		LCB5	813..1140	CDD:224513	172/331 (52%)
		DAGKc	814..942	CDD:214487	79/127 (62%)
		DAGKa	969..1123	CDD:214486	76/158 (48%)
		ANK	1329..1447	CDD:238125	41/117 (35%)
		ANK repeat	1329..1356	CDD:293786	10/26 (38%)
		Ank_2	1330..1425	CDD:289560	34/94 (36%)
		ANK repeat	1358..1391	CDD:293786	10/32 (31%)
		ANK repeat	1393..1425	CDD:293786	15/31 (48%)
		Ank_2	1399..>1459	CDD:289560	21/57 (37%)
dgki	XP_009298312.1	C1_1	189..247	CDD:278556	33/63 (52%)
		LCB5	310..625	CDD:224513	170/327 (52%)
		DAGKc	314..435	CDD:214487	79/127 (62%)
		DAGK_acc	458..615	CDD:295305	76/158 (48%)
		ANK	832..950	CDD:238125	41/117 (35%)
		ANK repeat	832..859	CDD:293786	10/26 (38%)
		Ank_2	833..928	CDD:289560	34/94 (36%)
		ANK repeat	861..896	CDD:293786	10/34 (29%)
		ANK repeat	898..928	CDD:293786	15/29 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	706	1.000	Inparanoid score	I642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143806at33208
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm24981
orthoMCL	1	0.900	-	-		OOG6_104636
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2485
SonicParanoid	1	1.000	-	-		X1934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000