Protein Alignment rdgA and dgki

DIOPT Version :10

• Sequence 1: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_009298312.1
• Gene: dgki / 100331649
• ZFINID: ZDB-GENE-120327-1
• Length: 968
• Species: Danio rerio
• Alignment Length: 1060
• Identity: 398/1060 - (37%)
• Similarity: 558/1060 - (52%)
• Gaps: 198/1060 - (18%)

  Fly   460 CGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFL 524
            ||...|.|||.:.||      ..|:...:.|..:..|......:.|..|.:..:.|.|:
Zfish    33 CGKNAAMGGSDSLSS------FADMDDSLEDKLKGLAFRKQISYRKAISRSGLQHLGPA------ 85

  Fly   525 TVPNINATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQG 589
                                 |..:.|||                :...:.:|...||:||||.|
Zfish    86 ---------------------QNPFPALS----------------NGPAKELRNTVDWSENAVNG 113

  Fly   590 EHYWKPTSASGDLCCLNEE-CI----KSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVG 649
            :|.|..|:.||:||.|.|| |:    ||..|.||:||::|.|..||..: :|....||||:|:..
Zfish   114 DHLWLETNCSGELCYLGEETCVAKIAKSAPRRKCAACKIVVHTACIEEL-DKINFRCKPTFREGS 177

  Fly   650 IRQYREQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEAC 714
            .|..|:|....||||||:.::|||:||||.||      .|.|.||||||::|:||.:.:|||..|
Zfish   178 SRCLRDQNVLRHHWVHRRRQEGKCRQCGKSFP------QKFFHSKEIVAISCSWCKQAFHNKVTC 236

  Fly   715 FNQAKIGEECRLGNYAPIIVPPSWIVKL-PTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGG 778
            |...:|.|.|.||.:|.:|||||||:|: ..:.:||:|.|
Zfish   237 FMLHQIEEPCSLGAHAGVIVPPSWIIKVRKPQSSFKNSTR------------------------- 276

  Fly   779 KSKKQT--QRR--QKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNP 839
             .||:|  :||  :||.:|.|. |.|::||:|||.:.||:||:|||||||||.|||..|..:|||
Zfish   277 -RKKRTSFKRRASKKGTDESKW-RPFMLKPLPSPLMKPVLVFVNPKSGGNQGTKLLQMFMWILNP 339

  Fly   840 RQVFDLTQGGPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGND 904
            ||||||:||||:..|:::||.||||:|||||||||||:||.||::|  :.|.|.|.|||||||||
Zfish   340 RQVFDLSQGGPRDALELYRKVPNLRILACGGDGTVGWILSALDELQ--MNPQPPVAVLPLGTGND 402

  Fly   905 LARALGWGGSIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPNVPLNV 969
            |||.|.|||     ||||||:.|:|..:.....|.:|||.::|   :.....| :.....:||||
Zfish   403 LARTLNWGG-----GYTDEPVSKVLCHVEDGSVVQLDRWNLQV---ERSVVQH-EEGTQKLPLNV 458

  Fly   970 INNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQ 1034
            .|||||.|.|||:.|||||:|||:||:||||.||||:|......|.:.|..|:||:.|.:.|||.
Zfish   459 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVRVVCDGT 523

  Fly  1035 DFTGKLRDAGCHAVLFLNIPSYGGGTHPWNDS-----FGASKPSIDDGLMEVVGLTTYQLPMLQA 1094
            |.|.|:::.....::|||||.|..||.||.::     |...:.  |||.:||:|.|...|..||.
Zfish   524 DLTAKIQELKFQCIVFLNIPRYCAGTMPWGNTGDHRDFEPQRH--DDGCIEVIGFTMASLAALQV 586

  Fly  1095 GMHGTCICQCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQVNPL-- 1157
            |.||..:.|||:..|.|.:|:|:|||||.||:.||.:.|.|.|:|.|:.|.|.......:|.:
Zfish   587 GGHGDRLHQCREVLITTFKTLPVQVDGEPCRLAPSTLRISLRNQANMVQKSKRRTSVPLLNDIQK 651

  Fly  1158 -----------------------EKMQLHILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCD 1199
                                   |:::|.:.|:.:|.|:...:|||.||.::..:|.:.:...||
Zfish   652 VCAADLRRLSAPPDSFSVPHAVPERLRLRVNRIGLQDYDSMQFDKERLRDISTAVGIVVVRGDCD 716

  Fly  1200 LEHVRNMLNTKFEESISYP----------------------KVSQDWCFIDSCTAEHYFRIDRAQ 1242
            ||..|..::...|:....|                      ::|.:|.|:||.:|:.::|||:||
Zfish   717 LETCRLYIDRLQEDLHQAPSAGHRVHYQDECAGLPRPSSAHRLSANWSFLDSTSADRFYRIDKAQ 781

  Fly  1243 EHLHYICDIAIDELYILDHEAATMPQTPDQERSFAAFSQRQAQNERRQMDQAQGRGPGSTDEDLQ 1307
            ||||::.:|..||:|||||||..:.|.                           |.||..|
Zfish   782 EHLHFVTEICQDEVYILDHEAPAVSQV---------------------------RAPGMPD---- 815

  Fly  1308 IGSKPIKVMKWKSPILEQTSD--AILLAAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYN 1370
                   |:...|..:..|||  |:|.||..|||..:.:....|.||...:..|.||||.|..:.
Zfish   816 -------VVVEPSSGVPLTSDEQALLSAAAKGDLTAVSSSCRSGLSLLVRDAMGCTALHLAAHHG 873

  Fly  1371 HRDIVKYIIASATRRLINMADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVA 1435
            |.|:|.:|:...::.::::.:::.|.||||.||.|.:||:|..|:.|||.....:..|.||...|
Zfish   874 HADVVSFILEHGSKLMLDLTERDTGDTALHKAAAQQQRDVCKRLLEAGASPHKTNFLGKTPKDCA 938

  Fly  1436 FNKNANEIATYLESKQGTQP 1455
            .:....|:|:.||.:...:|
Zfish   939 LDAGNLELASMLEIQAVDEP 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_DGK_typeIV_rpt1	586..647	CDD:410352	30/65 (46%)
		C1_DGK_typeIV_rpt2	661..727	CDD:410405	34/65 (52%)
		DAGKc	814..942	CDD:214487	79/127 (62%)
		DAGKa	969..1123	CDD:214486	76/158 (48%)
		ANKYR	<1329..1452	CDD:440430	43/122 (35%)
		ANK repeat	1329..1356	CDD:293786	10/26 (38%)
		ANK repeat	1358..1391	CDD:293786	10/32 (31%)
		ANK repeat	1393..1425	CDD:293786	15/31 (48%)
dgki	XP_009298312.1	C1_DGKiota_rpt1	105..177	CDD:410400	35/72 (49%)
		C1_DGKiota_rpt2	187..260	CDD:410446	41/78 (53%)
		DAGKc	314..435	CDD:214487	79/127 (62%)
		DAGK_acc	458..615	CDD:470579	76/158 (48%)
		ANKYR	<832..967	CDD:440430	44/127 (35%)
		ANK repeat	832..859	CDD:293786	10/26 (38%)
		ANK repeat	861..896	CDD:293786	10/34 (29%)
		ANK repeat	898..928	CDD:293786	15/29 (52%)