DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgA and dgkzb

DIOPT Version :9

Sequence 1:	NP_001259366.1	Gene:	rdgA / 31826	FlyBaseID:	FBgn0261549	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_003201445.1	Gene:	dgkzb / 100148835	ZFINID:	ZDB-GENE-111104-4	Length:	1300	Species:	Danio rerio

Alignment Length:	1498	Identity:	472/1498 - (31%)
Similarity:	672/1498 - (44%)	Gaps:	378/1498 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 KQQSSSSASADERSSEAGFLQVPLAAHQQRSHSFDSATASAGSDDSGTFLEVPRRLKARRSSSTK 171
            :.:..|.|....|:.....:.:|.:|..||..|.....|....:.|   ..|.::...||.|||.
Zfish    24 RHRRPSIAVPTSRARRRSSVGLPSSALTQRRRSSVQLQALPRINSS---QPVHQKSSGRRRSSTT 85

  Fly   172 TPPPCIHCHYLEEYERRMTAEQRYFIDHRELTALSYSNTS------------SEASEDEDEVEGH 224
            |                :.|..|:.:..:::..|...:|.            ....|:||:.||.
Zfish    86 T----------------LKANPRFAVRRKKVGKLRNIDTHLLGPSMLLASLIQMTQEEEDDEEGR 134

  Fly   225 N---AEEEEEGSAA---------IEDAEEETTEAATEEADEDPRTEVESE--HDHDPDDDAALEM 275
            :   .:.|.:||::         :.:.:.::.: ::|.::|...:.:..|  .:.|..|....|.
Zfish   135 SPLPGQVELKGSSSKFRSHTDVLLSEGDSDSDD-SSEHSEERQYSRIRKECLEEADGSDWGVKES 198

  Fly   276 DIRIGNMSQGSSIEESR------ARLPRQMRRHTIGSSSVTSASEDEGLEGSDNGSPHFGNTLLP 334
            .:.........|:...|      .|:||.:||:                      |.|:|:.
Zfish   199 GVLCQQDCLPLSVVAERIQAHPLIRVPRCLRRN----------------------SSHYGHA--- 238

  Fly   335 PQPTTPCGITFTLSPTNGDYPSPPHLPLDPGSPPISPCSSNSGRLPALAPIISTPCSSADADDAG 399
                                        ||| |.:..|.|:..|.......||      .|....
Zfish   239 ----------------------------DPG-PHVRYCRSSQRRRRRRVSTIS------KAGSPW 268

  Fly   400 AAMGLPVRARRRSISRQEAIFVEPTGNSLENVSHEEVDNSNTKSSVDTADSLDEASTMATCGSPG 464
            ...|||:..||.|..|..|.|     |.|....::
Zfish   269 PGRGLPLPNRRSSCYRGPATF-----NPLLGAYYD------------------------------ 298

  Fly   465 AAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFSKLSSNAKTEELQPSADGCFLTVPNI 529
                                         .|..|.....||..:.|..::
Zfish   299 -----------------------------PRLESWSGFLSKAIAKAGVQD--------------- 319

  Fly   530 NATRSRSVDIVLPTDEQARYKALSMTGSTVTYADGRTASASNSRRPIRIVPDWTENAVQGEHYWK 594
            ||.:|.::                            |.:.|...:.|....||||||..|:|.|.
Zfish   320 NAAQSGTI----------------------------TPAKSEPNKKICNTVDWTENAQLGQHVWF 356

  Fly   595 PTSASGDLCCLNE-ECI-----KSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQY 653
            .||.:||.|.:.| .||     ||..|.||:||::..|..|:..: :|....||||::|.|.:..
Zfish   357 ETSPAGDFCYVGESNCIAKSQQKSLPRHKCAACKISVHTECMNQL-DKINFRCKPTFKDPGTKNV 420

  Fly   654 REQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQA 718
            ||....:||||||:.:.|||:||||.|..|.:     |.||:|||::|:||.:.||||..||...
Zfish   421 RETPNMNHHWVHRRRQDGKCRQCGKGFQQKFS-----FHSKDIVAISCSWCKQAYHNKVNCFMMQ 480

  Fly   719 KIGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQ 783
            :|.|.|.||.:|.:|:||:||:::..:   ::|::.|.:....|               .|:|..
Zfish   481 RIDEPCSLGAHAAVIIPPTWIIRMRRQ---QASLKSSKRRKRTS---------------LKAKPS 527

  Fly   784 TQRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQG 848
            .:..|.||.     |.|:|:.|||..:.|::||:|||||||||.|::..|...||||||||||||
Zfish   528 KKLEQDGKW-----RNFVVRAIPSQHMKPLLVFVNPKSGGNQGTKIIRTFMWYLNPRQVFDLTQG 587

  Fly   849 GPKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGG 913
            ||:.||:|:.|.||||:|.|||||||||:|||||::|  |.|.|||.||||||||||||.|.|||
Zfish   588 GPREGLEMYSKVPNLRILVCGGDGTVGWILSVLDELQ--LNPQPAVAVLPLGTGNDLARTLNWGG 650

  Fly   914 SIFFQGYTDEPIGKILREIGMSQCVLMDRWRVKVTPNDDVTDDHVDRSKPN-VPLNVINNYFSFG 977
                 ||||||:.|||..:.....|.:|||.:.|..|.:.:|:..|..:.: :|::|.|||||.|
Zfish   651 -----GYTDEPVSKILSHVEDGIIVQLDRWNLSVEANLEASDEDKDEQQTDKLPIDVFNNYFSLG 710

  Fly   978 VDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTGKLRD 1042
            .|||:.|||||:|||.||||||||||||:|......|.::...::||:.:.:.|||.|.|.|::|
Zfish   711 FDAHVTLEFHESREAKPERFNSRLRNKMFYAGTAFSDFLMGSSKDLSKHIKVVCDGTDLTSKIQD 775

  Fly  1043 AGCHAVLFLNIPSYGGGTHPW-----NDSFGASKPSIDDGLMEVVGLTTYQLPMLQAGMHGTCIC 1102
            .....:||||||.|..||.||     |:.||..|.  ||||:||:|.|...:..||.|.||..:.
Zfish   776 MKVLCLLFLNIPRYCAGTMPWGNPSENNDFGPQKH--DDGLIEVIGFTMTSMATLQVGGHGERLH 838

  Fly  1103 QCRKARIITKRTIPMQVDGEACRVKPSVIEIELLNKALMLSKRKHGRGDVQV---NPL-EKMQLH 1163
            ||::..:.|.:.||:|||||.||:.||||.|...|:|.||.|.|......|:   .|: |.:|:.
Zfish   839 QCKEVTLTTFKPIPVQVDGEPCRLAPSVIHITRRNQANMLQKTKRRISLPQLYDQQPIAETVQIQ 903

  Fly  1164 ILRVTMQQYEQYHYDKEMLRKLANKLGQIEIESQCDLEHVRNMLNTKFEE-------SISYPKVS 1221
            :.|::|..||..|||||.|::.|..:|.|.:....|||..|..:....||       ::..||:|
Zfish   904 VNRISMHDYEALHYDKEQLKEAAIPMGIITVPGNSDLETCRQHIERLHEEGDGMNTDTLHMPKLS 968

  Fly  1222 QDWCFIDSCTAEHYFRIDRAQEHLHYICDIAIDELYILDHEAAT---------MP---------- 1267
            ..|||:|..||:.::||||.||||:|:.:|:.|||:|||.|..|         ||
Zfish   969 PKWCFLDCTTADRFYRIDRGQEHLNYVSEISQDELFILDPELVTKETVGTSPGMPGAMETVVGGC 1033

  Fly  1268 ---QTPDQERSFA------------------AFSQRQAQNERRQMD-QAQGRGPG---------- 1300
               .:.||   ||                  |.||.::.:|...|. |:....|.
Zfish  1034 GCSNSTDQ---FAFPACSPGPSPLCRVNETHAESQPESVSEEIDMHVQSDPESPTNLGVYRVHDT 1095

  Fly  1301 ---------STDEDLQIGSKP----------------------------IKVMK----WKSPILE 1324
                     |.:.|..:.|.|                            :.|.:    |...  :
Zfish  1096 HAESQLESLSPESDSHVQSDPGSPTKSGLYRRGAKNKISSRSNTLEEDSVNVQRLDTVWNKS--D 1158

  Fly  1325 QTSDAILL-AAQSGDLNMLRALHEQGYSLQSVNKNGQTALHFACKYNHRDIVKYIIASATRRLIN 1388
            |.|..:|. |.:||:|..|..:||:|..|...:..|.|.||.|....|::|||:|..:|...:::
Zfish  1159 QDSTNLLFDAVKSGNLEKLEQMHEEGADLSVQDHLGCTILHQAVILGHKEIVKFITENAPACILD 1223

  Fly  1389 MADKELGQTALHIAAEQNRRDICVMLVAAGAHLDTLDSGGNTPMMVAFNKNANEIATYLESKQGT 1453
            :.:|..|:||||.||....|.||..||.|||.|...|..|.||.|.|......|:|.|||::|..
Zfish  1224 VTEKSTGETALHKAAALCHRTICCYLVDAGASLMKTDLQGETPKMYAERTRDYELAEYLENQQHH 1288

  Fly  1454 QPV 1456
            |.:
Zfish  1289 QMI 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgA	NP_001259366.1	C1_1	591..640	CDD:278556	20/54 (37%)
		C1_1	661..725	CDD:278556	32/63 (51%)
		LCB5	813..1140	CDD:224513	177/332 (53%)
		DAGKc	814..942	CDD:214487	82/127 (65%)
		DAGKa	969..1123	CDD:214486	78/158 (49%)
		ANK	1329..1447	CDD:238125	46/118 (39%)
		ANK repeat	1329..1356	CDD:293786	10/27 (37%)
		Ank_2	1330..1425	CDD:289560	38/95 (40%)
		ANK repeat	1358..1391	CDD:293786	11/32 (34%)
		ANK repeat	1393..1425	CDD:293786	16/31 (52%)
		Ank_2	1399..>1459	CDD:289560	26/58 (45%)
dgkzb	XP_003201445.1	C1	428..487	CDD:294036	32/63 (51%)
		LCB5	549..867	CDD:224513	174/326 (53%)
		DAGKc	553..674	CDD:214487	82/127 (65%)
		DAGK_acc	702..859	CDD:295305	78/158 (49%)
		ANK	1155..1282	CDD:238125	48/128 (38%)
		Ank_2	1165..1260	CDD:289560	38/94 (40%)
		ANK repeat	1165..1191	CDD:293786	10/25 (40%)
		ANK repeat	1193..1227	CDD:293786	11/33 (33%)
		ANK repeat	1229..1254	CDD:293786	13/24 (54%)
		Ank_2	1234..>1299	CDD:289560	26/58 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590842
Domainoid	1	1.000	180	1.000	Domainoid score	I3453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	706	1.000	Inparanoid score	I642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143806at33208
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm24981
orthoMCL	1	0.900	-	-		OOG6_104636
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1934
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900