DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32850 and RNF6

DIOPT Version :9

Sequence 1:	NP_726563.1	Gene:	CG32850 / 318246	FlyBaseID:	FBgn0052850	Length:	147	Species:	Drosophila melanogaster
Sequence 2:	NP_005968.1	Gene:	RNF6 / 6049	HGNCID:	10069	Length:	685	Species:	Homo sapiens

Alignment Length:	145	Identity:	41/145 - (28%)
Similarity:	64/145 - (44%)	Gaps:	35/145 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DSQISGTQPVYHQGEHYQRELYPSTSSSTTLTPSSNNRQLSDENQ---------VKIA------- 68
            |.|..|.....| ||:      .:|...|..:.|...|||.:.|.         :::|
Human   539 DRQAQGDSTEMH-GEN------ETTQPHTRNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNE 596

  Fly    69 ----KRI-GL----MQYLPIGTYDGS---SKKARECVICMAEFCVNEAVRYLPCMHIYHVNCIDD 121
                .|| ||    :..|....|:.:   |:..:.|.:|::::.....:|.|||||.:|::|||.
Human   597 SDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDR 661

  Fly   122 WLLRSLTCPSCLEPV 136
            ||..:.|||.|.:||
Human   662 WLSENCTCPICRQPV 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32850	NP_726563.1	zf-RING_2	91..132	CDD:290367	17/40 (43%)
RNF6	NP_005968.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..142
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..273
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..345
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..576		12/43 (28%)
		Required for polyubiquitination. /evidence=ECO:0000250	607..685		23/70 (33%)
		RING-H2_RNF6	630..674	CDD:319587	18/43 (42%)
		RING-H2 finger (C3H2C3-type)	632..672	CDD:319587	17/39 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910