DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32850 and RNF38

DIOPT Version :9

Sequence 1:	NP_726563.1	Gene:	CG32850 / 318246	FlyBaseID:	FBgn0052850	Length:	147	Species:	Drosophila melanogaster
Sequence 2:	NP_073618.3	Gene:	RNF38 / 152006	HGNCID:	18052	Length:	515	Species:	Homo sapiens

Alignment Length:	139	Identity:	36/139 - (25%)
Similarity:	61/139 - (43%)	Gaps:	33/139 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SQISGTQPV----YHQGEHYQRELYPSTSSSTTLTPS-----SNNRQLSD------ENQVKIAKR 70
            |:....||:    ||.      .|.|...|...:.|:     |....:.|      |..:.:|:|
Human   371 SRYRSQQPIPPPPYHP------SLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAER 429

  Fly    71 IGL----------MQYLPIGTYDGSSKKARE--CVICMAEFCVNEAVRYLPCMHIYHVNCIDDWL 123
            :|.          ::.||...::.::.::.:  ||:||.:|...:.:|.|||.|.:|..|:|.||
Human   430 LGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWL 494

  Fly   124 LRSLTCPSC 132
            ..:.|||.|
Human   495 KANRTCPIC 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32850	NP_726563.1	zf-RING_2	91..132	CDD:290367	18/42 (43%)
RNF38	NP_073618.3	Bipartite nuclear localization signal 1	57..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..141
		Bipartite nuclear localization signal 2	115..131
		RING-H2_RNF38_like	460..504	CDD:319386	19/44 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910