DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32847 and RNF185

DIOPT Version :9

Sequence 1:	NP_730026.1	Gene:	CG32847 / 318245	FlyBaseID:	FBgn0052847	Length:	164	Species:	Drosophila melanogaster
Sequence 2:	NP_689480.2	Gene:	RNF185 / 91445	HGNCID:	26783	Length:	192	Species:	Homo sapiens

Alignment Length:	158	Identity:	69/158 - (43%)
Similarity:	106/158 - (67%)	Gaps:	7/158 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ESFYECNICLDTAQNAVVSMCGHLFCWPCLYQWILTKPDHTVCPVCKSGVDRSKVIPVYARNDKR 77
            :|.:|||||||||::||:|:||||||||||:||:.|:|:..||||||:|:.|.||||:|.|....
Human    34 DSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTG 98

  Fly    78 QEDPRDKTPPRPTGIWSDYANDLELGLFSY------LLFGL-FFPYGALSSYLDMDEPLNPAADH 135
            |:|||:||||||.|...:..|......|.:      :.||: .||:|..::..::::...|.|..
Human    99 QQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVP 163

  Fly   136 GIRDGQNETLLSKFFLYVAIMLIIYMIV 163
            |.....:|..||:.||:||::::.::::
Human   164 GTPQYVDEQFLSRLFLFVALVIMFWLLI 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32847	NP_730026.1	PLN03208	4..>91	CDD:178747	51/77 (66%)
CG32847	NP_730026.1	RING	17..60	CDD:238093	31/42 (74%)
RNF185	NP_689480.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Required for ubiquitin ligase activity and protection against ER stress-induced cell death. /evidence=ECO:0000269\|PubMed:27485036	29..80		31/45 (69%)
		RING-HC_RNF185	38..80	CDD:319658	30/41 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..123		15/32 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5574
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1510545at2759
OrthoFinder	1	1.000	-	-		FOG0000717
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102074
Panther	1	1.100	-	-	O	PTHR12313
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.710