DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdic3 and Dic61B

DIOPT Version :9

Sequence 1:	NP_001285482.2	Gene:	Sdic3 / 318231	FlyBaseID:	FBgn0052823	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	627	Identity:	127/627 - (20%)
Similarity:	231/627 - (36%)	Gaps:	169/627 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSTYSTLSGGKKQPLNLSVYNV--QATNIPPKETL----------VYTK---------------- 46
            ||:.....||.||.::..:..:  :..|..|..|:          .|||
  Fly   123 RSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVEALEEAYEPKPYTKSFLKITLRKSDFFEIH 187

  Fly    47 -QTQTT-STGGGNGDVLAFDAQGDDEESSLQNLGNG----------------FTSK--------- 84
             ||||| :.|...||    ||:.|:.......:|.|                ||::
  Fly   188 SQTQTTVAKGSPEGD----DAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTILITK 248

  Fly    85 ------------------LPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQM-- 129
                              :...:.|..:.:|||:..|:...|.....|..:.|.|..:...|:
  Fly   249 ATVSSYVSNFEMYDTLNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQIER 313

  Fly   130 IILSENFQRFVVRAGRVIERALSE-------NVDIYTDYIGGGDSEEANDERSHARLSLNRVF-- 185
            :..|..|:..::..||.:....:|       |.|         ..|..|.|..:. .|:|.:|
  Fly   314 LFRSPEFRNAIMYMGRTLSSNTNEAGLRRFRNFD---------QVERWNAEAEYV-YSMNLLFRL 368

  Fly   186 -----YDERWSKNRCITSMDWSTHFPELVVGSY----HNNEESPNEPDGVVMVWNTKFKKSTPED 241
                 .|||    :.::.:|:.....:::..:|    .:::..|.  .|.|.:|:.| ....||.
  Fly   369 VPEPSKDER----KAVSDIDFCRSNGDILAVAYGLYSFSSQHVPT--SGSVFLWSIK-NPGEPER 426

  Fly   242 VFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVG- 305
            .::....|.:..|:.|.|:|:..|.|.|.:.:.|....:.||:..:..|.:..:.||..::.:.
  Fly   427 AYYYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQ 491

  Fly   306 -TQNAHNV-----ISISSDGKLCSW----SLDMLSQPQDTLEL-------------------QQR 341
             :.:.|..     :|:|.||.:..:    |..:|...|..||.                   ..|
  Fly   492 VSDDDHETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCESNR 556

  Fly   342 QSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVN------EVYERHLGPITGISTHY 400
            ..:.::||:  .|.::....|: :::|.::..|       :|      ||...|.|.:|.:
  Fly   557 HPQGLSITT--HPLHKDIYYVL-TDEGCIHKCS-------INYQHQYLEVLRCHDGGVTVM---- 607

  Fly   401 NQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDL 465
             :.||....||||...||.:::|....|:||....|....|....|||.|..:...|:.. ..::
  Fly   608 -EFSPWSPKLFLTCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVNRE-TANV 670

  Fly   466 WNLNQDTEVPIASIVVAGAPALNRVS-WTPSGLHVCIGDEAG 506
            |:..::...|::...:..  :.|.|: ::..|..:.||:|.|
  Fly   671 WDFRRNLLRPMSKHKMDS--SFNTVARFSHCGRTLVIGNERG 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic3	NP_001285482.2	Dynein_IC2	23..51	CDD:288403	9/56 (16%)
		NtpH	108..>178	CDD:225368	15/78 (19%)
		WD40	196..512	CDD:295369	74/352 (21%)
		WD40 repeat	196..245	CDD:293791	9/52 (17%)
		WD40	<224..523	CDD:225201	71/320 (22%)
		WD40 repeat	251..289	CDD:293791	10/37 (27%)
		WD40 repeat	298..337	CDD:293791	9/49 (18%)
		WD40 repeat	349..435	CDD:293791	23/91 (25%)
		WD40 repeat	441..479	CDD:293791	8/37 (22%)
		WD40 repeat	487..513	CDD:293791	7/21 (33%)
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	80/379 (21%)
		WD40 repeat	381..429	CDD:293791	9/50 (18%)
		WD40	433..711	CDD:295369	65/296 (22%)
		WD40 repeat	434..473	CDD:293791	11/38 (29%)
		WD40 repeat	552..599	CDD:293791	10/56 (18%)
		WD40 repeat	604..637	CDD:293791	11/37 (30%)
		WD40 repeat	645..682	CDD:293791	8/37 (22%)
		WD40 repeat	691..727	CDD:293791	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940