Protein Alignment Sdic3 and DYNC1I2

DIOPT Version :10

• Sequence 1: NP_728323.3
• Gene: Sdic3 / 318231
• FlyBaseID: FBgn0052823
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001369.1
• Gene: DYNC1I2 / 1781
• HGNCID: 2964
• Length: 638
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 282/527 - (53%)
• Similarity: 372/527 - (70%)
• Gaps: 52/527 - (9%)

  Fly    23 PLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPP 87
            |:.|.:..:...:.||:|.:.|||:|||        .|:|...:.::|:..:
Human   135 PIKLGMAKITQVDFPPREIVTYTKETQT--------PVMAQPKEDEEEDDDV------------- 178

  Fly    88 GYLTHGLPTVKDVAPAITPLEIKKETEVKKE--------VNELSEEQKQMIILSENFQRFVVRAG 144
                        |||. .|:|.::|..:||:        .:||:||:||.|:.||.|..|...:.
Human   179 ------------VAPK-PPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHST 230

  Fly   145 RVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELV 209
            |::||||||.::|:.||.|....::..:.::.|:|||||.|:||||||:|.::.:|||:.:|||:
Human   231 RIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELL 295

  Fly   210 VGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLW 274
            |.||:|||::|:|||||.:|||.|:||:|||.||||||||||..||||:|||::|||||||||||
Human   296 VASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW 360

  Fly   275 DNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQ 339
            |||..||||:||||||||||||||||:.:||||||||:||||:|||:|||||||||.|||::||.
Human   361 DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELV 425

  Fly   340 QRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLS 404
            .:||||:|:|||:||..::|:.|:|||:|.||:|.|||.::|::|::|.|.||||||..|....:
Human   426 HKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGA 490

  Fly   405 PDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLN 469
            .||.|||:|||.|||:|||:.|:.|||||||||:|||.||.|||.||||||.|||.|||||||||
Human   491 VDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLN 555

  Fly   470 QDTEVPIASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRD----------E 524
            .|||||.|||.|.|.||||||.||.||..:.:||..|::.:|||.|.:|.|..|          |
Human   556 NDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAE 620

  Fly   525 IKMNQSD 531
            |..|::|
Human   621 INANRAD 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdic3	NP_728323.3	Dynein_IC2	21..51	CDD:463291	10/27 (37%)
		WD40	196..512	CDD:475233	213/315 (68%)
		WD40 repeat	196..245	CDD:293791	29/48 (60%)
		WD40 repeat	251..289	CDD:293791	29/37 (78%)
		WD40 repeat	298..337	CDD:293791	30/38 (79%)
		WD40 repeat	349..435	CDD:293791	48/85 (56%)
		WD40 repeat	441..479	CDD:293791	30/37 (81%)
		WD40 repeat	487..513	CDD:293791	12/25 (48%)
DYNC1I2	NP_001369.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		282/527 (54%)
		Dynein_IC2	133..163	CDD:463291	11/35 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..214		21/92 (23%)
		WD 1	277..326		28/48 (58%)
		WD40 repeat	282..331	CDD:293791	29/48 (60%)
		WD40	<310..413	CDD:441893	82/102 (80%)
		WD 2	330..370		32/39 (82%)
		WD40 repeat	339..377	CDD:293791	30/37 (81%)
		WD 3	379..420		33/40 (83%)
		WD40	380..>605	CDD:475233	146/224 (65%)
		WD40 repeat	385..426	CDD:293791	31/40 (78%)
		WD 4	429..469		22/39 (56%)
		WD40 repeat	434..481	CDD:293791	24/46 (52%)
		WD 5	474..519		26/44 (59%)
		WD40 repeat	489..521	CDD:293791	20/31 (65%)
		WD 6	522..562		32/39 (82%)
		WD40 repeat	527..565	CDD:293791	30/37 (81%)
		WD 7	568..607		19/38 (50%)
		WD40 repeat	573..599	CDD:293791	12/25 (48%)