DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32819 and TEKT3

DIOPT Version :9

Sequence 1:	NP_728444.1	Gene:	CG32819 / 318227	FlyBaseID:	FBgn0052819	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_114104.1	Gene:	TEKT3 / 64518	HGNCID:	14293	Length:	490	Species:	Homo sapiens

Alignment Length:	502	Identity:	182/502 - (36%)
Similarity:	291/502 - (57%)	Gaps:	52/502 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NEYNERKDHRNLMESYPWSQAGAPPCMEPVMGPSIPPRVGAAYETPTKHPWRPAMAYELIQVKHM 158
            :.|.:|..|.||..|                               ...||||:..|::  ..:.
Human    31 SSYRDRFPHSNLTHS-------------------------------LSLPWRPSTYYKV--ASNS 62

  Fly   159 PEQPVTNQLTKQCFLPKGMKTDGMIFPNLVTGFDRNPQHAARAALYTRYTSNEWYNNNMTKYSES 223
            |      .:...|...:.:..:.|:           |..:.|...:||||.::||.:|:|.|.||
Human    63 P------SVAPYCTRSQRVSENTML-----------PFVSNRTTFFTRYTPDDWYRSNLTNYQES 110

  Fly   224 NMNRNLSERMRNDAVRLMRETDEKATSGQRDAGRRLGERITDLTFWRNELNAELEKLIAEMSDIN 288
            |.:|:.||::|.|..||:::..::....|.|..:.||||:.|:.||::|:..||:::|.|.:.:.
Human   111 NTSRHNSEKLRVDTSRLIQDKYQQTRKTQADTTQNLGERVNDIGFWKSEIIHELDEMIGETNALT 175

  Fly   289 ELQRQCGKALLDLEIPLHIAQECLFHRESRQGTEKVHDIVEKALLVEINNLRNSRDRLGGLH-EK 352
            :::::..:||::.|.||.:|:|||||||.|.|.:.|||.||..||.|::.:...::|: .|| :|
Human   176 DVKKRLERALMETEAPLQVARECLFHREKRMGIDLVHDEVEAQLLTEVDTILCCQERM-KLHLDK 239

  Fly   353 ISKQALDCRGAQHLLEDDVSHKESSLGIDSMCHQLNNHSRGITYYGGIEKFDPSVSTQESWAQAS 417
            ...|....|.:||.||.|:|.|:::..||..||.|.|.|.|:.|:.|:|:.|.:||..||||:.:
Human   240 AIAQLAANRASQHELEKDLSDKQTAYRIDDKCHHLRNTSDGVGYFRGVERVDATVSVPESWAKFT 304

  Fly   418 SEHVRRSQAERAKLSQLRSDAQSVVNSVATTVWDFWSNTNNAFDRRSQEMAEAKNRVQLHLQKVQ 482
            .:::.|||:|||..::||.|.::::...|..:|:.::..|.:|..|..|.|:|||::|.||.|..
Human   305 DDNILRSQSERAASAKLRDDIENLLVVTANEMWNQFNKVNLSFTNRIAETADAKNKIQTHLAKTL 369

  Fly   483 QELFDMEKHLFLLQKAIQDKSGPLKVAQTRLEARSHREGVELCKDHAQDRLVQEVQDIQGAVETL 547
            ||:|..|..:..::|||:||:..||||||||:.|:.|..:|||:|.||.|||.||.::...::||
Human   370 QEIFQTEMTIESIKKAIKDKTAFLKVAQTRLDERTRRPNIELCRDMAQLRLVNEVHEVDDTIQTL 434

  Fly   548 HHKLMEAEATHQGLLKTRCTLEVDLRNKVNALFIDREKCMSLRRSFP 594
            ..:|.:||.|.|.|:..:.|||.||..|.|:|:||:|||||:|:|:|
Human   435 QQRLRDAEDTLQSLVHIKATLEYDLAVKANSLYIDQEKCMSMRKSYP 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32819	NP_728444.1	Tektin	212..591	CDD:281184	159/379 (42%)
TEKT3	NP_114104.1	Tektin	99..478	CDD:281184	159/379 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158896
Domainoid	1	1.000	329	1.000	Domainoid score	I1158
eggNOG	1	0.900	-	-		E1_KOG2685
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12896
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2349
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59762
OrthoDB	1	1.010	-	-		D264325at33208
OrthoFinder	1	1.000	-	-		FOG0000711
OrthoInspector	1	1.000	-	-		otm41082
orthoMCL	1	0.900	-	-		OOG6_108589
Panther	1	1.100	-	-	LDO	PTHR19960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3872
SonicParanoid	1	1.000	-	-		X3619
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800